DISEASE: Uncomplicated urinary tract infection


Entry
H01176                      Disease                                
Name
Uncomplicated urinary tract infection
Description
Staphylococci are widespread as commensals of humans and animals where they colonize the skin or mucous membranes. Staphylococcus saprophyticus is a coagulase-negative Staphylococcus, gram-positive uropathogen and frequently isolated from young female outpatients presenting with uncomplicated urinary tract infections. S. saprophyticus causes uncomplicated urinary tract infection (UTI) but no severe bacterial infectious disease as caused by S. aureus. The urease of S. saprophyticus is known to be a virulent factor for the persistent infection in the urinary tract. All of the virulence factors of S. aureus, such as coagulase, hemolysins, enterotoxins, extracellular matrixbinding proteins, and exoenzymes, are absent in the S. saprophyticus genome. Besides S. saprophyticus is a leading gram-positive uropathogen of uncomplicated UTI, a restricted group of gram-negative bacteria, including Escherichia coli, Proteus mirabilis, and Klebsiella spp. is often observed to cause uncomplicated UTI.
Category
Infectious disease
Brite
Infectious diseases [BR:br08401]
 Bacterial infections
  Infections caused by Gram-positive bacteria
   H01176  Uncomplicated urinary tract infection
Human diseases in ICD-11 classification [BR:br08403]
 16 Diseases of the genitourinary system
  Diseases of the urinary system
   Certain specified diseases of urinary system
    GC08  Urinary tract infection, site not specified
     H01176  Uncomplicated urinary tract infection
Pathogen
Staphylococcus saprophyticus [GN:ssp]
Mammaliicoccus lentus [GN:mlen]
Drug
Acetohydroxamic acid [DR:D00220]
Cefuroxime axetil [DR:D00914]
Ceftriaxone sodium [DR:D00924]
Cefixime [DR:D07640]
Cefepime hydrochloride [DR:D01157]
Aztreonam [DR:D00240]
Imipenem, cilastatin and relebactam [DR:D11621]
Trimethoprim [DR:D00145]
Trimethoprim hydrochloride [DR:D11085]
Ciprofloxacin hydrochloride [DR:D02216]
Levofloxacin [DR:D00588]
Nitrofurantoin [DR:D00439]
Other DBs
ICD-11: GC08
ICD-10: B95 N39
MeSH: D013203 D014552
MedlinePlus: 000521
Reference
PMID:16135568
  Authors
Kuroda M, Yamashita A, Hirakawa H, Kumano M, Morikawa K, Higashide M, Maruyama A, Inose Y, Matoba K, Toh H, Kuhara S, Hattori M, Ohta T.
  Title
Whole genome sequence of Staphylococcus saprophyticus reveals the pathogenesis of uncomplicated urinary tract infection.
  Journal
Proc Natl Acad Sci U S A 102:13272-7 (2005)
DOI:10.1073/pnas.0502950102

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Ontology (1)   
   KEGG BRITE (1)   
Drug (12)   
   KEGG DRUG (12)   
Genome (2)   
   KEGG GENOME (2)   
Literature (1)   
   PubMed (1)   
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