Entry

H00368                      Disease

Name

Cytomegalovirus infection;
CMV infection

Description

Cytomegalovirus (CMV) is a double-stranded DNA virus of the Herpesviridae family acquired by late childhood in the majority of individuals. Primary infection is nonspecific but after that the virus becomes latent in multiple organs and can later be reactivated. CMV is an important and common cause of mortality and morbidity in immunocompromised patients such as those with HIV/AIDS or transplant recipients on immunosuppressive therapy.

Category

Infectious disease

Brite

Infectious diseases [BR:br08401]
Viral infections
  Infections caused by dsDNA viruses
   H00368  Cytomegalovirus infection
Human diseases in ICD-11 classification [BR:br08403]
01 Certain infectious or parasitic diseases
  Certain other viral diseases
   1D82  Cytomegaloviral disease
    H00368  Cytomegalovirus infection

Pathway

hsa05163

Human cytomegalovirus infection

Network

nt06110  MAPK signaling (viruses and bacteria)
nt06114  PI3K signaling (viruses)
nt06119  JAK-STAT signaling (viruses)
nt06123  TNF signaling (viruses and bacteria)
nt06124  Chemokine signaling (viruses)
nt06129  MHC presentation (viruses)
nt06130  Cell cycle (viruses)
nt06131  Apoptosis (viruses and bacteria)
nt06134  CGAS-STING signaling (viruses and bacteria)
nt06135  Cytoskeletal regulation (viruses and bacteria)
nt06150  Cytokine-cytokine receptor interaction (viruses)
nt06167  Human cytomegalovirus (HCMV)

Pathogen

Human herpesvirus 5 (Human cytomegalovirus) [GN:T40080]

Drug

Ganciclovir [DR:D00333]
Ganciclovir sodium [DR:D04301]
Cidofovir [DR:D00273]
Valganciclovir hydrochloride [DR:D03256]
Foscarnet sodium [DR:D00579]
Maribavir [DR:D04859]
Letermovir [DR:D10801]

Other DBs

ICD-11:

1D82

ICD-10:

B20.2 B25 B27.1 P35.1

MeSH:

D003586

Reference

PMID:21970493

Authors

Chisholm C, Lopez L

Title

Cutaneous infections caused by Herpesviridae: a review.

Journal

Arch Pathol Lab Med 135:1357-62 (2011)
DOI:10.5858/arpa.2010-0156-RS

Reference

PMID:21748845

Authors

Fishman JA

Title

Infections in immunocompromised hosts and organ transplant recipients: essentials.

Journal

Liver Transpl 17 Suppl 3:S34-7 (2011)
DOI:10.1002/lt.22378

Reference

PMID:21056604

Authors

Jackson SE, Mason GM, Wills MR

Title

Human cytomegalovirus immunity and immune evasion.

Journal

Virus Res 157:151-60 (2011)
DOI:10.1016/j.virusres.2010.10.031

Reference

PMID:21841300

Authors

Jain M, Duggal S, Chugh TD

Title

Cytomegalovirus infection in non-immunosuppressed critically ill patients.

Journal

J Infect Dev Ctries 5:571-9 (2011)
DOI:10.3855/jidc.1487

Reference

PMID:21827433

Authors

Ross SA, Novak Z, Pati S, Boppana SB

Title

Overview of the diagnosis of cytomegalovirus infection.

Journal

Infect Disord Drug Targets 11:466-74 (2011)
DOI:10.2174/187152611797636703

DISEASE: Cytomegalovirus infection