DISEASE: Asthma with nasal polyps and aspirin intolerance

Entry

H01191                      Disease

Name

Asthma with nasal polyps and aspirin intolerance

Description

Asthma is a phenotypically heterogeneous disorder with many etiologic factors and clinical characteristics. In some patients with asthma, aspirin and all nonsteroidal anti-inflammatory drugs (NSAIDs) trigger asthmatic attacks. This clinical syndrome is characterized by eosinophilic inflammation of nasal and bronchial tissue, often associated with nasal polyps. It has been reported that genetic variations in TBX21 are associated with susceptibility to asthma with nasal polyps and aspirin intolerance.

Category

Immune system disease

Brite

Human diseases [BR:br08402]
Immune system diseases
  Allergies and autoimmune diseases
   H01191  Asthma with nasal polyps and aspirin intolerance
Human diseases in ICD-11 classification [BR:br08403]
12 Diseases of the respiratory system
  Certain lower respiratory tract diseases
   CA23  Asthma
    H01191  Asthma with nasal polyps and aspirin intolerance

Gene

TBX21 [HSA:30009] [KO:K10166]
PTGER2 [HSA:5732] [KO:K04259]

Other DBs

ICD-11:

CA23.20

ICD-10:

J45

MeSH:

C565935

OMIM:

208550

Reference

PMID:15806396

Authors

Akahoshi M, Obara K, Hirota T, Matsuda A, Hasegawa K, Takahashi N, Shimizu M, Nakashima K, Cheng L, Doi S, Fujiwara H, Miyatake A, Fujita K, Higashi N, Taniguchi M, Enomoto T, Mao XQ, Nakashima H, Adra CN, Nakamura Y, Tamari M, Shirakawa T

Title

Functional promoter polymorphism in the TBX21 gene associated with aspirin-induced asthma.

Journal

Hum Genet 117:16-26 (2005)
DOI:10.1007/s00439-005-1285-0

Reference

PMID:21370724

Authors

Schaper C, Noga O, Koch B, Ewert R, Felix SB, Glaser S, Kunkel G, Gustavus B

Title

Anti-inflammatory properties of montelukast, a leukotriene receptor antagonist in patients with asthma and nasal polyposis.

Journal

J Investig Allergol Clin Immunol 21:51-8 (2011)

Reference

PMID:15496426

Authors

Jinnai N, Sakagami T, Sekigawa T, Kakihara M, Nakajima T, Yoshida K, Goto S, Hasegawa T, Koshino T, Hasegawa Y, Inoue H, Suzuki N, Sano Y, Inoue I

Title

Polymorphisms in the prostaglandin E2 receptor subtype 2 gene confer susceptibility to aspirin-intolerant asthma: a candidate gene approach.

Journal

Hum Mol Genet 13:3203-17 (2004)
DOI:10.1093/hmg/ddh332

» Japanese version

All links

Disease (1)   
   OMIM (1)   
Gene (4)   
   KEGG ORTHOLOGY (2)   
   KEGG GENES (2)   
Literature (3)   
   PubMed (3)   
All databases (8)   

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