Entry

H01358                      Disease

Name

Atopic dermatitis

Description

Atopic dermatitis (AD) is a relapsing chronic inflammatory skin disease characterized by eczematous skin lesions and intense pruritus. A genetic defect in the filaggrin (FLG) protein and/or environmental factors are thought to cause AD by disrupting the epidermis. This disruption, in turn, results in contact between immune cells in the dermis and antigens from the external environment leading to intense itching, scratching, and inflammation. Apart from FLG, recent genome-wide association studies (GWASs) have identified many susceptibility loci of atopic dermatitis with genome-wide significance.

Category

Immune system disease

Brite

Human diseases [BR:br08402]
Immune system diseases
  Allergies and autoimmune diseases
   H01358  Atopic dermatitis
Skin diseases
  Skin and soft tissue diseases
   H01358  Atopic dermatitis
Human diseases in ICD-11 classification [BR:br08403]
14 Diseases of the skin
  Inflammatory dermatoses
   Dermatitis and eczema
    EA80  Atopic eczema
     H01358  Atopic dermatitis

Related
pathway

hsa04621

NOD-like receptor signaling pathway

hsa04620

Toll-like receptor signaling pathway

hsa04151

PI3K-Akt signaling pathway

Gene

FLG (mutation) [HSA:2312] [KO:K10384]
IL4 (polymorphism) [HSA:3656] [KO:K04731]
IL4RA (polymorphism) [HSA:3566] [KO:K05071]
SPINK5 (polymorphism) [HSA:11005] [KO:K23420]
IL13 (polymorphism) [HSA:3596] [KO:K05435]
RANTES (polymorphism) [HSA:6352] [KO:K12499]
NOD1 (polymorphism) [HSA:10392] [KO:K08727]
CARD15 (polymorphism) [HSA:64127] [KO:K10165]
TLR-2 (polymorphism) [HSA:7097] [KO:K10159]
TLR-9 (polymorphism) [HSA:54106] [KO:K10161]
COL29A1 (polymorphism) [HSA:256076] [KO:K06238]

Pathogen

Staphylococcus aureus
Malassezia sympodialis [GN:msym]

Drug

Triamcinolone acetonide [DR:D00983]
Dexamethasone [DR:D00292]
Dexamethasone sodium phosphate [DR:D00975]
Hydrocortisone [DR:D00088]
Hydrocortisone sodium succinate [DR:D00978]
Hydrocortisone butyrate [DR:D01619]
Prednisolone [DR:D00472]
Prednisolone sodium phosphate [DR:D00981]
Prednisone [DR:D00473]
Doxepin hydrochloride [DR:D00814]
Methylprednisolone [DR:D00407]
Methylprednisolone sodium succinate [DR:D00751]
Methylprednisolone acetate [DR:D00979]
Desonide [DR:D03696]
Tacrolimus [DR:D00107]
Pimecrolimus [DR:D05480]
Dupilumab [DR:D10354]
Crisaborole [DR:D10873]
Tralokinumab [DR:D09979]
Abrocitinib [DR:D11400]
Cortisone acetate [DR:D00973]
Ruxolitinib phosphate [DR:D09960]
Upadacitinib hydrate [DR:D11048]
Hydroxyzine hydrochloride [DR:D00672]
Hydroxyzine pamoate [DR:D01096]

Other DBs

ICD-11:

EA80

ICD-10:

L20

MeSH:

D003876

OMIM:

605803

Reference

PMID:23473856

Authors

Kabashima K

Title

New concept of the pathogenesis of atopic dermatitis: interplay among the barrier, allergy, and pruritus as a trinity.

Journal

J Dermatol Sci 70:3-11 (2013)
DOI:10.1016/j.jdermsci.2013.02.001

Reference

PMID:23439055

Authors

Tamari M, Tanaka S, Hirota T

Title

Genome-wide association studies of allergic diseases.

Journal

Allergol Int 62:21-8 (2013)
DOI:10.2332/allergolint.13-RAI-0539

Reference

PMID:21518425

Authors

Bussmann C, Weidinger S, Novak N

Title

Genetics of atopic dermatitis.

Journal

J Dtsch Dermatol Ges 9:670-6 (2011)
DOI:10.1111/j.1610-0387.2011.07656.x

Reference

PMID:20109730

Authors

Barnes KC

Title

An update on the genetics of atopic dermatitis: scratching the surface in 2009.

Journal

J Allergy Clin Immunol 125:16-29.e1-11; quiz 30-1 (2010)
DOI:10.1016/j.jaci.2009.11.008

Reference

PMID:22962911

Authors

Berke R, Singh A, Guralnick M

Title

Atopic dermatitis: an overview.

Journal

Am Fam Physician 86:35-42 (2012)

Reference

PMID:16815133

Authors

Cork MJ, Robinson DA, Vasilopoulos Y, Ferguson A, Moustafa M, MacGowan A, Duff GW, Ward SJ, Tazi-Ahnini R

Title

New perspectives on epidermal barrier dysfunction in atopic dermatitis: gene-environment interactions.

Journal

J Allergy Clin Immunol 118:3-21; quiz 22-3 (2006)
DOI:10.1016/j.jaci.2006.04.042

Reference

PMID:22586797

Authors

Cookson H, Smith C

Title

Systemic treatment of adult atopic dermatitis.

Journal

Clin Med 12:172-6 (2012)
DOI:10.1038/ng1767

Reference

PMID:20070141

Authors

Simpson EL

Title

Atopic dermatitis: a review of topical treatment options.

Journal

Curr Med Res Opin 26:633-40 (2010)
DOI:10.1185/03007990903512156

Reference

PMID:24354911

Authors

Simon D, Bieber T

Title

Systemic therapy for atopic dermatitis.

Journal

Allergy 69:46-55 (2014)
DOI:10.1111/all.12339

DISEASE: Atopic dermatitis