DISEASE: Anaphylaxis

Entry

H01359                      Disease

Name

Anaphylaxis

Description

Anaphylaxis is a severe, life-threatening, systemic allergic reaction that is almost always unanticipated and may lead to death by airway obstruction or vascular collapse. Anaphylaxis can be triggered by a broad range of triggers. Food is the commonest trigger in children and drugs the commonest in adults. In addition to the environmental influences, studies suggest that a complex of genes affects the anaphylactic response. Anaphylaxis occurs as the result of an allergen response, usually immunoglobulin E-mediated, which leads to mast cell and basophil activation and a combination of dermatologic, respiratory, cardiovascular, gastrointestinal, and neurologic symptoms.

Category

Immune system disease

Brite

Human diseases [BR:br08402]
Immune system diseases
  Allergies and autoimmune diseases
   H01359  Anaphylaxis
Human diseases in ICD-11 classification [BR:br08403]
04 Diseases of the immune system
  Allergic or hypersensitivity conditions
   4A84  Anaphylaxis
    H01359  Anaphylaxis

Gene

c-KIT (mutation) [HSA:3815] [KO:K05091]
NLRP3 (polymorphism) [HSA:114548] [KO:K12800]
IL-10 (polymorphism) [HSA:3586] [KO:K05443]

Drug

Epinephrine [DR:D00095]

Other DBs

ICD-11:

4A84

MeSH:

D000707

Reference

PMID:20560905

Authors

Ben-Shoshan M, Clarke AE

Title

Anaphylaxis: past, present and future.

Journal

Allergy 66:1-14 (2011)
DOI:10.1111/j.1398-9995.2010.02422.x

Reference

PMID:22085665

Authors

Arnold JJ, Williams PM

Title

Anaphylaxis: recognition and management.

Journal

Am Fam Physician 84:1111-8 (2011)

Reference

PMID:20236436

Authors

Younker J, Soar J

Title

Recognition and treatment of anaphylaxis.

Journal

Nurs Crit Care 15:94-8 (2010)
DOI:10.1111/j.1478-5153.2010.00366.x

Reference

PMID:20176258

Authors

Simons FE

Title

Anaphylaxis.

Journal

J Allergy Clin Immunol 125:S161-81 (2010)
DOI:10.1016/j.jaci.2009.12.981

Reference

PMID:21682750

Authors

Boden SR, Wesley Burks A

Title

Anaphylaxis: a history with emphasis on food allergy.

Journal

Immunol Rev 242:247-57 (2011)
DOI:10.1111/j.1600-065X.2011.01028.x

» Japanese version

All links

Drug (4)   
   KEGG DRUG (4)   
Gene (6)   
   KEGG ORTHOLOGY (3)   
   KEGG GENES (3)   
Literature (5)   
   PubMed (5)   
All databases (15)   

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