DISEASE: Eosinophilic esophagitis


Entry
H01361                      Disease                                
Name
Eosinophilic esophagitis
Description
Eosinophilic esophagitis (EoE) is a chronic immune and antigen-mediated clinicopathologic disease that is characterized by eosinophil infiltration into the esophageal epithelium and results in esophageal fibrosis and dysfunction. Several factors contribute to the development of EoE, including genetic predisposition, history of allergies, and presence of environmental and food allergens. Recently, an association between a single nuclear polymorphism (SNP) in the gene encoding thymic stromal lymphopoietin (TSLP) or eotaxin-3 (CCL-26) and risk for EoE was found.
Category
Immune system disease
Brite
Human diseases [BR:br08402]
 Immune system diseases
  Allergies and autoimmune diseases
   H01361  Eosinophilic esophagitis
Human diseases in ICD-11 classification [BR:br08403]
 13 Diseases of the digestive system
  Diseases of oesophagus
   DA24  Oesophagitis
    H01361  Eosinophilic esophagitis
Related
pathway
hsa04062  Chemokine signaling pathway
hsa04630  JAK-STAT signaling pathway
Gene
TSLP (polymorphism) [HSA:85480] [KO:K05436]
CCL-26 (polymorphism) [HSA:10344] [KO:K21096]
Other DBs
ICD-11: DA24.1
MeSH: D057765
Reference
PMID:22313241
  Authors
Straumann A, Aceves SS, Blanchard C, Collins MH, Furuta GT, Hirano I, Schoepfer AM, Simon D, Simon HU
  Title
Pediatric and adult eosinophilic esophagitis: similarities and differences.
  Journal
Allergy 67:477-90 (2012)
DOI:10.1111/j.1398-9995.2012.02787.x
Reference
PMID:21228772
  Authors
Mulder DJ, Justinich CJ
  Title
Understanding eosinophilic esophagitis: the cellular and molecular mechanisms of an emerging disease.
  Journal
Mucosal Immunol 4:139-47 (2011)
DOI:10.1038/mi.2010.88
Reference
PMID:17088129
  Authors
Blanchard C, Wang N, Rothenberg ME
  Title
Eosinophilic esophagitis: pathogenesis, genetics, and therapy.
  Journal
J Allergy Clin Immunol 118:1054-9 (2006)
DOI:10.1016/j.jaci.2006.07.038
Reference
PMID:24566295
  Authors
Merves J, Muir A, Modayur Chandramouleeswaran P, Cianferoni A, Wang ML, Spergel JM
  Title
Eosinophilic esophagitis.
  Journal
Ann Allergy Asthma Immunol 112:397-403 (2014)
DOI:10.1016/j.anai.2014.01.023
Reference
PMID:23130328
  Authors
Ridolo E, Montagni M, Olivieri E, Rogkakou A, De' Angelis GL, Canonica GW
  Title
Eosinophilic esophagitis: which role for food and inhalant allergens?
  Journal
Asia Pac Allergy 2:237-41 (2012)
DOI:10.5415/apallergy.2012.2.4.237
Reference
PMID:21991511
  Authors
Shahzad G, Mustacchia P, Frieri M
  Title
Role of mucosal inflammation in eosinophilic esophagitis: review of the literature.
  Journal
ISRN Gastroenterol 2011:468073 (2011)
DOI:10.5402/2011/468073
Reference
PMID:23001405
  Authors
Redd M, Schey R
  Title
Eosinophilic esophagitis: current treatment.
  Journal
Dig Dis Sci 58:613-20 (2013)
DOI:10.1007/s10620-012-2383-1
Reference
PMID:22034864
  Authors
Abonia JP, Rothenberg ME
  Title
Eosinophilic esophagitis: rapidly advancing insights.
  Journal
Annu Rev Med 63:421-34 (2012)
DOI:10.1146/annurev-med-041610-134138

» Japanese version

  All links  
Gene (4)   
   KEGG ORTHOLOGY (2)   
   KEGG GENES (2)   
Literature (8)   
   PubMed (8)   
All databases (12)   

Download RDF