DISEASE: Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection

Entry

H01452                      Disease

Name

Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection

Description

Pediatric autoimmune neuropsychiatric disorder associated with streptococcal infections (PANDAS) is an autoimmune disorder presenting with obsessive compulsive disorder (OCD) and/or tics. PANDAS is believed to be caused by antibodies generated in response to a group A beta-hemolytic streptococcal (GAS) infection in genetically susceptible individuals. PANDAS is defined by five diagnostic criteria: (1) the presence of OCD and/or a tic disorder, (2) prepubertal symptom onset, (3) an abrupt onset of symptoms that are episodic in severity, (4) a temporal association between symptom exacerbations and GAS infections, and (5) the presence of neurological abnormalities (e.g., choreiform movements) during exacerbations. It has been reported that antibiotics and immunomodulatory therapies (plasma exchange and IVIG) were effective in lessening of symptom severity.

Category

Immune system disease

Brite

Human diseases [BR:br08402]
Immune system diseases
  Allergies and autoimmune diseases
   H01452  Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection
Human diseases in ICD-11 classification [BR:br08403]
08 Diseases of the nervous system
  Other disorders of the nervous system
   8E4A  Paraneoplastic or autoimmune disorders of the nervous system
    H01452  Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection

Pathogen

Group A beta-hemolytic streptococcus

Other DBs

ICD-11:

8E4A.0

ICD-10:

B95.0

MeSH:

C537163

Reference

PMID:26196024

Authors

Helm CE, Blackwood RA

Title

Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal Infections (PANDAS): Experience at a Tertiary Referral Center.

Journal

Tremor Other Hyperkinet Mov (N Y) 5:270 (2015)
DOI:10.7916/D8348JCX

Reference

PMID:15241433

Authors

Snider LA, Swedo SE

Title

PANDAS: current status and directions for research.

Journal

Mol Psychiatry 9:900-7 (2004)
DOI:10.1038/sj.mp.4001542

Reference

PMID:18495013

Authors

Moretti G, Pasquini M, Mandarelli G, Tarsitani L, Biondi M

Title

What every psychiatrist should know about PANDAS: a review.

Journal

Clin Pract Epidemiol Ment Health 4:13 (2008)
DOI:10.1186/1745-0179-4-13

» Japanese version

All links

Literature (3)   
   PubMed (3)   
All databases (3)   

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