DISEASE: Lupus nephritis

Entry

H01500                      Disease

Name

Lupus nephritis

Description

Lupus nephritis is a severe organ manifestation of systemic lupus erythematosus (SLE) that can affect up to 70% of the SLE population. In childhood SLE, nephritis is present in up to 90% of the cases. This disease is one of the most serious complications of SLE, with a high morbidity and mortality. Clinical manifestations of active lupus nephritis include proteinuria, active urinary sediments, and progressive renal dysfunction. It is initiated by the deposition of immunoglobulins and formation of immune complexes in the glomerular and tubulo-interstitial compartments of the kidney. There is emerging evidence that the interaction between anti-dsDNA antibodies and kidney cells, notably mesangial cells, proximal renal tubular epithelial cells, and glomerular endothelial cells plays a significant role in disease pathogenesis.

Category

Immune system disease; Urinary system disease

Brite

Human diseases [BR:br08402]
Immune system diseases
  Allergies and autoimmune diseases
   H01500  Lupus nephritis
Urinary system diseases
  Kidney diseases
   H01500  Lupus nephritis
Human diseases in ICD-11 classification [BR:br08403]
04 Diseases of the immune system
  Nonorgan specific systemic autoimmune disorders
   4A40  Lupus erythematosus
    H01500  Lupus nephritis

Drug

Voclosporin [DR:D09033]

Comment

See also H00080 Systemic lupus erythematosus.
Lupus nephritis is staged according to the classification revised by the International Society of Nephrology (ISN) and the Renal Pathology Society (RPS) in 2003.

Other DBs

ICD-11:

4A40.0Y

ICD-10:

M32.1 N08.5

MeSH:

D008181

OMIM:

607965 607966 607967

Reference

PMID:14747370

Authors

Weening JJ, D'Agati VD, Schwartz MM, Seshan SV, Alpers CE, Appel GB, Balow JE, Bruijn JA, Cook T, Ferrario F, Fogo AB, Ginzler EM, Hebert L, Hill G, Hill P, Jennette JC, Kong NC, Lesavre P, Lockshin M, Looi LM, Makino H, Moura LA, Nagata M

Title

The classification of glomerulonephritis in systemic lupus erythematosus revisited.

Journal

J Am Soc Nephrol 15:241-50 (2004)
DOI:10.1097/01.ASN.0000108969.21691.5D

Reference

PMID:22761629

Authors

Yung S, Chan TM

Title

Autoantibodies and resident renal cells in the pathogenesis of lupus nephritis: getting to know the unknown.

Journal

Clin Dev Immunol 2012:139365 (2012)
DOI:10.1155/2012/139365

Reference

PMID:12215904

Authors

Quintero-Del-Rio AI, Kelly JA, Kilpatrick J, James JA, Harley JB

Title

The genetics of systemic lupus erythematosus stratified by renal disease: linkage at 10q22.3 (SLEN1), 2q34-35 (SLEN2), and 11p15.6 (SLEN3).

Journal

Genes Immun 3 Suppl 1:S57-62 (2002)
DOI:10.1038/sj.gene.6363901

Reference

PMID:22570338

Authors

Wang S, Li X, Qu L, Wang R, Chen Y, Li Q, He X, Zhang X, Wang H, Wu J, Xu Y, Chen J

Title

Tacrolimus versus cyclophosphamide as treatment for diffuse proliferative or membranous lupus nephritis: a non-randomized prospective cohort study.

Journal

Lupus 21:1025-35 (2012)
DOI:10.1177/0961203312448105

Reference

PMID:19479701

Authors

Pons-Estel GJ, Alarcon GS, McGwin G Jr, Danila MI, Zhang J, Bastian HM, Reveille JD, Vila LM

Title

Protective effect of hydroxychloroquine on renal damage in patients with lupus nephritis: LXV, data from a multiethnic US cohort.

Journal

Arthritis Rheum 61:830-9 (2009)
DOI:10.1002/art.24538

» Japanese version

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Disease (3)   
   OMIM (3)   
Drug (4)   
   KEGG DRUG (4)   
Literature (5)   
   PubMed (5)   
All databases (12)   

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