Entry

H01726                      Disease

Name

Membranoproliferative glomerulonephritis

Subgroup

Dense deposit disease (DDD)
C3 glomerulopathy (C3G) [DS:H02579]
Immunoglobulin-mediated membranoproliferative glomerulonephritis

Description

Membranoproliferative glomerulonephritis (MPGN) represents a pattern of glomerular injury, characterized by mesangial proliferation and expansion, lobularization of the glomerular tufts, and double contours. Classification of MPGN has been updated in the 2010s and is now categorized according to the immunofluorescence microscopy findings. MPGN is now recognized as follows: Immunocomplexes-associated MPGN with complement over activation; MPGN with intramembranous dense deposits; and C3 glomerulopathy.

Category

Immune system disease; Urinary system disease

Brite

Human diseases [BR:br08402]
Immune system diseases
  Allergies and autoimmune diseases
   H01726  Membranoproliferative glomerulonephritis
Urinary system diseases
  Kidney diseases
   H01726  Membranoproliferative glomerulonephritis
Human diseases in ICD-11 classification [BR:br08403]
21 Symptoms, signs or clinical findings, not elsewhere classified
  Symptoms, signs or clinical findings of the genitourinary system
   Clinical findings in specimens from the urinary system
    MF8Y  Other specified clinical findings in specimens from the urinary system
     H01726  Membranoproliferative glomerulonephritis

Related
pathway

hsa04610

Complement and coagulation cascades

Gene

CFH [HSA:3075] [KO:K04004]
CFHR5 [HSA:81494] [KO:K23817]
DGKE [HSA:8526] [KO:K00901]

Other DBs

ICD-11:

MF8Y

ICD-10:

N03

MeSH:

D015432

OMIM:

609814 614809 615008

Reference

PMID:27356907

Authors

Lionaki S, Gakiopoulou H, Boletis JN

Title

Understanding the complement-mediated glomerular diseases: focus on membranoproliferative glomerulonephritis and C3 glomerulopathies.

Journal

APMIS 124:725-35 (2016)
DOI:10.1111/apm.12566

Reference

PMID:27458560

Authors

Salvadori M, Rosso G

Title

Reclassification of membranoproliferative glomerulonephritis: Identification of a new GN: C3GN.

Journal

World J Nephrol 5:308-20 (2016)
DOI:10.5527/wjn.v5.i4.308

Reference

PMID:26921911

Authors

Floege J, Amann K

Title

Primary glomerulonephritides.

Journal

Lancet 387:2036-48 (2016)
DOI:10.1016/S0140-6736(16)00272-5

DISEASE: Membranoproliferative glomerulonephritis