Entry

H00030                      Disease

Name

Cervical cancer

Description

Cervical cancer is the second largest cause of cancer-related death in women worldwide, and it occurs following persistent infection, sometimes for decades, with a specific subset of human papillomavirus (HPV) types, particularly types 16, 18, 33 and 42. Experimental studies show that the E6 and E7 genes of these high risk HPVs are oncogenes that deregulate key cell cycle controls. The E6 and E7 oncoproteins bind respectively to the p53 and Retinoblastoma (Rb) tumor suppressor proteins, which are involved in the regulation of growth control. The abnormalities in other cellular genes found in cervical cancer, including mutations in ras family of genes, and amplification in EGFR and ERBB2, may also play an important role in carcinogenesis and the aggressiveness of cervical tumors, although to date the role of most of these genetic abnormalities does not appear to be as important as the role of HPV.

Category

Cancer

Brite

Human diseases [BR:br08402]
Cancers
  Cancers of the breast and female genital organs
   H00030  Cervical cancer
Human diseases in ICD-11 classification [BR:br08403]
02 Neoplasms
  Malignant neoplasms, except primary neoplasms of lymphoid, haematopoietic, central nervous system or related tissues
   Malignant neoplasms, stated or presumed to be primary, of specified sites, except of lymphoid, haematopoietic, central nervous system or related tissues
    Malignant neoplasms of female genital organs
     2C77  Malignant neoplasms of cervix uteri
      H00030  Cervical cancer
Cancer-associated carbohydrates [br08441.html]
H00030

Related
pathway

hsa05165

Human papillomavirus infection

Network

nt06110  MAPK signaling (viruses and bacteria)
nt06114  PI3K signaling (viruses)
nt06121  TLR signaling (viruses and bacteria)
nt06122  IFN signaling (viruses)
nt06123  TNF signaling (viruses and bacteria)
nt06129  MHC presentation (viruses)
nt06130  Cell cycle (viruses)
nt06131  Apoptosis (viruses and bacteria)
nt06135  Cytoskeletal regulation (viruses and bacteria)
nt06140  Transcription (viruses)
nt06150  Cytokine-cytokine receptor interaction (viruses)
nt06166  Human papillomavirus (HPV)
nt06511  NOTCH signaling

Gene

K-ras (mutation) [HSA:3845] [KO:K07827]
H-ras (mutation) [HSA:3265] [KO:K02833]
EGFR (amplification) [HSA:1956] [KO:K04361]
ERBB2 (amplification) [HSA:2064] [KO:K05083]
p21 (overexpression) [HSA:1026] [KO:K06625]
CDK4 (overexpression) [HSA:1019] [KO:K02089]
Bcl-2 (overexpression) [HSA:596] [KO:K02161]

Pathogen

Human papillomavirus type 16 [GN:T40087]
Human papillomavirus type 18 [GN:T40088]

Drug

Recombinant adsorbed quadrivalent human papillomavirus virus-like particle vaccine [DR:D10192]
Topotecan hydrochloride [DR:D02168]
Pembrolizumab [DR:D10574] (PD-L1 expressed)
Bevacizumab [DR:D06409]
Tisotumab vedotin [DR:D11814]

Other DBs

ICD-11:

2C77

ICD-10:

C53

MeSH:

D002583

Reference

PMID:11486705

Authors

Wolf JK, Ramirez PT.

Title

The molecular biology of cervical cancer.

Journal

Cancer Invest 19:621-9 (2001)
DOI:10.1081/CNV-100104290

Reference

PMID:10471054

Authors

Lazo PA.

Title

The molecular genetics of cervical carcinoma.

Journal

Br J Cancer 80:2008-18 (1999)
DOI:10.1038/sj.bjc.6690635

Reference

PMID:16062089

Authors

Patel P, Moazzam N, Potti A, Mehdi SA.

Title

Azathioprine induced hodgkin lymphoma: a case report and review of literature.

Journal

Am J Clin Oncol 28:427-8 (2005)
DOI:10.1097/01.coc.0000168670.28659.8d

Reference

PMID:15168959

Authors

Schrager S, Potter BE.

Title

Diethylstilbestrol exposure.

Journal

Am Fam Physician 69:2395-400 (2004)

Reference

PMID:17390375

Authors

Troisi R, Hatch EE, Titus-Ernstoff L, Hyer M, Palmer JR, Robboy SJ, Strohsnitter WC, Kaufman R, Herbst AL, Hoover RN.

Title

Cancer risk in women prenatally exposed to diethylstilbestrol.

Journal

Int J Cancer 121:356-60 (2007)
DOI:10.1002/ijc.22631

Reference

PMID:11281434

Authors

Severson J, Evans TY, Lee P, Chan T, Arany I, Tyring SK.

Title

Human papillomavirus infections: epidemiology, pathogenesis, and therapy.

Journal

J Cutan Med Surg 5:43-60 (2001)
DOI:10.1177/120347540100500110

Reference

PMID:15489140

Authors

Wogan GN, Hecht SS, Felton JS, Conney AH, Loeb LA.

Title

Environmental and chemical carcinogenesis.

Journal

Semin Cancer Biol 14:473-86 (2004)
DOI:10.1016/j.semcancer.2004.06.010

Reference

PMID:15552776

Authors

Sasco AJ, Secretan MB, Straif K.

Title

Tobacco smoking and cancer: a brief review of recent epidemiological evidence.

Journal

Lung Cancer 45 Suppl 2:S3-9 (2004)
DOI:10.1016/j.lungcan.2004.07.998

Reference

PMID:12612656

Authors

Baldwin P, Laskey R, Coleman N.

Title

Translational approaches to improving cervical screening.

Journal

Nat Rev Cancer 3:217-26 (2003)
DOI:10.1038/nrc1010

Reference

PMID:12797857

Authors

Garland SM.

Title

Can we really beat cervical cancer?

Journal

Med J Aust 178:647-9 (2003)
DOI:10.5694/j.1326-5377.2003.tb05396.x

Reference

PMID:14739059

Authors

Gadducci A, Cosio S, Carpi A, Nicolini A, Genazzani AR.

Title

Serum tumor markers in the management of ovarian, endometrial and cervical cancer.

Journal

Biomed Pharmacother 58:24-38 (2004)
DOI:10.1016/j.biopha.2003.11.003

DISEASE: Cervical cancer