Entry

H01554                      Disease

Name

Fallopian tube cancer

Description

Fallopian tube cancer is a rare, aggressive gynecologic malignancy. Recent genetic and immunohistochemical studies strongly suggest that high-grade serous adenocarcinoma (SAC) involving the ovary likely arises from distal fallopian tube epithelium, indicating that some ovarian cancers develop in the fallopian tube and are then spread to the ovary. Fallopian tube cancers are similar to ovarian cancer with respect to the proportion of tumors with abnormal expression of c-erbB-2 and p53. It has been proposed that the p53 signature is the earliest step in the pathogenesis of fallopian tube cancer. In this model, tubal epithelium on the fimbria experiences genotoxic damage and, as a result, the secretory cell exhibits over-accumulation of p53 protein (p53 signature). There is also some evidence that BRCA-1 and BRCA-2 mutations and c-myc have a major role in tumorgenesis.

Category

Cancer

Brite

Human diseases [BR:br08402]
Cancers
  Cancers of the breast and female genital organs
   H01554  Fallopian tube cancer
Human diseases in ICD-11 classification [BR:br08403]
02 Neoplasms
  Malignant neoplasms, except primary neoplasms of lymphoid, haematopoietic, central nervous system or related tissues
   Malignant neoplasms, stated or presumed to be primary, of specified sites, except of lymphoid, haematopoietic, central nervous system or related tissues
    Malignant neoplasms of female genital organs
     2C74  Malignant neoplasms of fallopian tube
      H01554  Fallopian tube cancer

Gene

BRCA1 (mutation) [HSA:672] [KO:K10605]
BRCA2 (mutation) [HSA:675] [KO:K08775]
TP53 (overexpression) [HSA:7157] [KO:K04451]
ERBB2 (overexpression) [HSA:2064] [KO:K05083]
c-myc (overexpression) [HSA:4609] [KO:K04377]

Drug

Bevacizumab [DR:D06409]
Niraparib tosilate hydrate [DR:D11895]

Other DBs

ICD-11:

2C74

ICD-10:

C57.0

MeSH:

D005185

Reference

PMID:25286779

Authors

Horng HC, Teng SW, Huang BS, Sun HD, Yen MS, Wang PH, Tsui KH, Wen KC, Chen YJ, Chuang CM, Chao HT, Chang WH

Title

Primary fallopian tube cancer: domestic data and up-to-date review.

Journal

Taiwan J Obstet Gynecol 53:287-92 (2014)
DOI:10.1016/j.tjog.2014.07.003

Reference

PMID:23622731

Authors

Kalampokas E, Kalampokas T, Tourountous I

Title

Primary fallopian tube carcinoma.

Journal

Eur J Obstet Gynecol Reprod Biol 169:155-61 (2013)
DOI:10.1016/j.ejogrb.2013.03.023

Reference

PMID:23937438

Authors

Nik NN, Vang R, Shih IeM, Kurman RJ

Title

Origin and pathogenesis of pelvic (ovarian, tubal, and primary peritoneal) serous carcinoma.

Journal

Annu Rev Pathol 9:27-45 (2014)
DOI:10.1146/annurev-pathol-020712-163949

Reference

PMID:21922146

Authors

Haruta S, Furukawa N, Yoshizawa Y, Tsunemi T, Nagai A, Kawaguchi R, Tanase Y, Yoshida S, Kobayashi H

Title

Molecular genetics and epidemiology of epithelial ovarian cancer (Review).

Journal

Oncol Rep 26:1347-56 (2011)
DOI:10.3892/or.2011.1456

Reference

PMID:24511245

Authors

Sama AR, Schilder RJ

Title

Refractory fallopian tube carcinoma - current perspectives in pathogenesis and management.

Journal

Int J Womens Health 6:149-57 (2014)
DOI:10.2147/IJWH.S40889

Reference

PMID:7773939

Authors

Lacy MQ, Hartmann LC, Keeney GL, Cha SC, Wieand HS, Podratz KC, Roche PC

Title

c-erbB-2 and p53 expression in fallopian tube carcinoma.

Journal

Cancer 75:2891-6 (1995)
DOI:10.1002/1097-0142(19950615)75:12<2891::AID-CNCR2820751216>3.0.CO;2-B

Reference

PMID:23240669

Authors

Vang R, Shih IeM, Kurman RJ

Title

Fallopian tube precursors of ovarian low- and high-grade serous neoplasms.

Journal

Histopathology 62:44-58 (2013)
DOI:10.1111/his.12046

Reference

PMID:25315029

Authors

Keating GM

Title

Bevacizumab: a review of its use in advanced cancer.

Journal

Drugs 74:1891-925 (2014)
DOI:10.1007/s40265-014-0302-9

DISEASE: Fallopian tube cancer