Entry

H02530                      Disease

Name

Hereditary prostate cancer

Supergrp

Prostate cancer [DS:H00024]

Description

Hereditary prostate cancer (HPC) has been used to characterize families with a particularly strong history of prostate cancer and includes those families with either: three or more affected first-degree relatives, prostate cancer diagnosed in three successive generations of the same lineage, or two first-degree relatives both diagnosed with early-onset disease. Familial cancer loci have been found, but the genes that cause familial prostate cancer remain largely elusive.

Category

Cancer

Brite

Human diseases [BR:br08402]
Cancers
  Cancers of male genital organs
   H02530  Hereditary prostate cancer
Human diseases in ICD-11 classification [BR:br08403]
02 Neoplasms
  Malignant neoplasms, except primary neoplasms of lymphoid, haematopoietic, central nervous system or related tissues
   Malignant neoplasms, stated or presumed to be primary, of specified sites, except of lymphoid, haematopoietic, central nervous system or related tissues
    Malignant neoplasms of male genital organs
     2C82  Malignant neoplasms of prostate
      H02530  Hereditary prostate cancer

Gene

(HPC1) RNASEL [HSA:6041] [KO:K01165]
(HPC2) ELAC2 [HSA:60528] [KO:K00784]
(HPC9) HOXB13 [HSA:10481] [KO:K09298]
(HPC12) EHBP1 [HSA:23301] [KO:K25572]
(HPC13) MSMB [HSA:4477] [KO:K25684]

Other DBs

ICD-11:

2C82

ICD-10:

C61

MeSH:

C537243

OMIM:

601518 614731 610997 611868 611928

Reference

PMID:15534086

Authors

Wiklund F, Jonsson BA, Brookes AJ, Stromqvist L, Adolfsson J, Emanuelsson M, Adami HO, Augustsson-Balter K, Gronberg H

Title

Genetic analysis of the RNASEL gene in hereditary, familial, and sporadic prostate cancer.

Journal

Clin Cancer Res 10:7150-6 (2004)
DOI:10.1158/1078-0432.CCR-04-0982

Reference

PMID:10986046

Authors

Rebbeck TR, Walker AH, Zeigler-Johnson C, Weisburg S, Martin AM, Nathanson KL, Wein AJ, Malkowicz SB

Title

Association of HPC2/ELAC2 genotypes and prostate cancer.

Journal

Am J Hum Genet 67:1014-9 (2000)
DOI:10.1086/303096

Reference

PMID:22236224

Authors

Ewing CM, Ray AM, Lange EM, Zuhlke KA, Robbins CM, Tembe WD, Wiley KE, Isaacs SD, Johng D, Wang Y, Bizon C, Yan G, Gielzak M, Partin AW, Shanmugam V, Izatt T, Sinari S, Craig DW, Zheng SL, Walsh PC, Montie JE, Xu J, Carpten JD, Isaacs WB, Cooney KA

Title

Germline mutations in HOXB13 and prostate-cancer risk.

Journal

N Engl J Med 366:141-9 (2012)
DOI:10.1056/NEJMoa1110000

Reference

PMID:26185455

Authors

Ao X, Liu Y, Bai XY, Qu X, Xu Z, Hu G, Chen M, Wu H

Title

Association between EHBP1 rs721048(A>G) polymorphism and prostate cancer susceptibility: a meta-analysis of 17 studies involving 150,678 subjects.

Journal

Onco Targets Ther 8:1671-80 (2015)
DOI:10.2147/OTT.S84034

Reference

PMID:19383797

Authors

Lou H, Yeager M, Li H, Bosquet JG, Hayes RB, Orr N, Yu K, Hutchinson A, Jacobs KB, Kraft P, Wacholder S, Chatterjee N, Feigelson HS, Thun MJ, Diver WR, Albanes D, Virtamo J, Weinstein S, Ma J, Gaziano JM, Stampfer M, Schumacher FR, Giovannucci E, Cancel-Tassin G, Cussenot O, Valeri A, Andriole GL, Crawford ED, Anderson SK, Tucker M, Hoover RN, Fraumeni JF Jr, Thomas G, Hunter DJ, Dean M, Chanock SJ

Title

Fine mapping and functional analysis of a common variant in MSMB on chromosome 10q11.2 associated with prostate cancer susceptibility.

Journal

Proc Natl Acad Sci U S A 106:7933-8 (2009)
DOI:10.1073/pnas.0902104106

Reference

PMID:27899188

Authors

Giri VN, Beebe-Dimmer JL

Title

Familial prostate cancer.

Journal

Semin Oncol 43:560-565 (2016)
DOI:10.1053/j.seminoncol.2016.08.001

DISEASE: Hereditary prostate cancer