| Entry |
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| Name | Tobramycin (JP18/USP); Tobi (TN); Tobracin (TN); Tobrex (TN); Bethkis (TN) | ||||||||||||
| Product | TOBREX (Alcon Laboratories), TOBREX (Alcon Laboratories), BETHKIS (Chiesi USA), TOBI (Mylan Specialty L.P.), TOBI PODHALER (Mylan Specialty L.P.), TOBI PODHALER (Mylan Specialty L.P.), TOBREX (Novartis Pharmaceuticals Corporation), TOBI (Novartis Pharmaceuticals Corporation), KITABIS PAK (Pari Respiratory Equipment) | ||||||||||||
| Generic | TOBRAMYCIN (A-S Medication Solutions), TOBRAMYCIN (A-S Medication Solutions), TOBRAMYCIN (A-S Medication Solutions), TOBRAMYCIN (Akorn), TOBRAMYCIN (Akorn), TOBRAMYCIN (Amneal Pharmaceuticals LLC), TOBRAMYCIN (Ascend Laboratories), TOBRAMYCIN (Asclemed USA), TOBRAMYCIN (Aurobindo Pharma Limited), TOBRAMYCIN (Bausch & Lomb Incorporated), TOBRAMYCIN (DirectRX), TOBRAMYCIN (FOSUN PHARMA USA), TOBRAMYCIN (Genericus), TOBRAMYCIN (Gland Pharma Limited), TOBRAMYCIN (Henry Schein), TOBRAMYCIN (Lupin Pharmaceuticals), TOBRAMYCIN (MWI), TOBRAMYCIN (Medsource Pharmaceuticals), TOBRAMYCIN (NuCare Pharmaceuticals), TOBRAMYCIN (NuCare Pharmaceuticals), TOBRAMYCIN (NuCare Pharmaceuticals), TOBRAMYCIN (Preferred Pharmaceuticals), TOBRAMYCIN (Preferred Pharmaceuticals), TOBRAMYCIN (Proficient Rx LP), TOBRAMYCIN (Proficient Rx LP), TOBRAMYCIN (Proficient Rx LP), TOBRAMYCIN (Proficient Rx LP), TOBRAMYCIN (Quality Care Products), TOBRAMYCIN (REMEDYREPACK), TOBRAMYCIN (RPK Pharmaceuticals), TOBRAMYCIN (RPK Pharmaceuticals), TOBRAMYCIN (RPK Pharmaceuticals), TOBRAMYCIN (RPK Pharmaceuticals), TOBRAMYCIN (Sandoz), TOBRAMYCIN (Somerset Therapeutics), TOBRAMYCIN (St. Mary's Medical Park Pharmacy), TOBRAMYCIN (Sun Pharmaceutical Industries), TOBRAMYCIN (Teva Pharmaceuticals USA), TOBRAMYCIN (Teva Pharmaceuticals USA), TOBRAMYCIN INHALATION (Prasco), TOBRAMYCIN INHALATION SOLUTION (Dr. Reddy's Laboratories), TOBRAMYCIN INHALATION SOLUTION (NorthStar RxLLC), TOBRAMYCIN OPHTHALMIC SOLUTION (Alembic Pharmaceuticals) | ||||||||||||
| Formula | C18H37N5O9 | ||||||||||||
| Exact mass | 467.2591 | ||||||||||||
| Mol weight | 467.5145 | ||||||||||||
| Structure |  | ||||||||||||
| Simcomp | |||||||||||||
| Source | Streptomyces tenebrarius [TAX:1933] | ||||||||||||
| Class | Antibacterial DG01447 Aminoglycoside antibiotic | ||||||||||||
| Remark |
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| Efficacy | Antibacterial, Protein biosynthesis inhibitor | ||||||||||||
| Disease | Cystic fibrosis patients with Pseudomonas aeruginosa [DS:H00218] | ||||||||||||
| Target | 50S ribosomal subunit 30S ribosomal subunit | ||||||||||||
| Pathway |
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| Interaction | |||||||||||||
| Biosynthesis |
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| Structure map |
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| Brite | Anatomical Therapeutic Chemical (ATC) classification [BR:br08303] J ANTIINFECTIVES FOR SYSTEMIC USE J01 ANTIBACTERIALS FOR SYSTEMIC USE J01G AMINOGLYCOSIDE ANTIBACTERIALS J01GB Other aminoglycosides J01GB01 Tobramycin D00063 Tobramycin (JP18/USP) <JP/US> S SENSORY ORGANS S01 OPHTHALMOLOGICALS S01A ANTIINFECTIVES S01AA Antibiotics S01AA12 Tobramycin D00063 Tobramycin (JP18/USP) <JP/US> USP drug classification [BR:br08302] Antibacterials Aminoglycosides Tobramycin D00063 Tobramycin (JP18/USP) Ophthalmic Agents Ophthalmic Anti-Infectives Antibacterials, Ophthalmic Tobramycin D00063 Tobramycin (JP18/USP) Respiratory Tract/Pulmonary Agents Cystic Fibrosis Agents Inhaled Anti-infectives Tobramycin D00063 Tobramycin (JP18/USP) Therapeutic category of drugs in Japan [BR:br08301] 1 Agents affecting nervous system and sensory organs 13 Agents affecting sensory organs 131 Ophthalmic agents 1317 Ophthalmic antibiotics D00063 Tobramycin (JP18/USP) 6 Agents against pathologic organisms and parasites 61 Antibiotics 612 Acting mainly on gram-negative bacteria 6123 Amino sugars D00063 Tobramycin (JP18/USP) Drug groups [BR:br08330] Antibacterial DG01447 Aminoglycoside antibiotic DG00608 Tobramycin D00063 Tobramycin Drug classes [BR:br08332] Antibacterial DG01447 Aminoglycoside antibiotic D00063 Tobramycin Antimicrobials [BR:br08307] Antibacterials Protein biosynthesis inhibitor Aminoglycoside D00063 Tobramycin (JP18/USP) <JP/US> Drugs listed in the Japanese Pharmacopoeia [BR:br08311] Chemicals D00063 Tobramycin D00063 Tobramycin injection New drug approvals in Europe [br08329.html] European public assessment reports (EPAR) authorised medicine D00063 Drug groups [BR:br08330] Antibacterial DG01447 Aminoglycoside antibiotic DG00608 Tobramycin Antimicrobials abbreviations [BR:br08327] Antibacterials Protein biosynthesis inhibitor Aminoglycoside DG00608 Tobramycin | ||||||||||||
| Other DBs |
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| KCF data | ATOM 32 1 C1y C 20.6560 -20.0968 2 C1y C 20.6560 -21.4973 3 C1y C 21.8689 -22.1975 4 C1y C 23.0818 -21.4973 5 C1y C 23.0818 -20.0968 6 O2x O 21.8689 -19.3965 7 C1b C 19.4432 -19.3965 8 O1a O 18.2473 -20.0872 9 O1a O 19.4432 -22.1975 10 N1a N 21.8689 -23.5978 11 O1a O 24.3134 -22.2085 12 O2a O 24.3134 -19.3855 13 C1y C 25.4878 -18.6963 14 C1y C 26.7056 -19.3879 15 C1x C 27.9134 -18.6791 16 C1y C 27.9035 -17.2786 17 C1y C 26.6857 -16.5869 18 C1y C 25.4779 -17.2958 19 N1a N 26.7157 -20.7965 20 N1a N 29.0779 -16.5893 21 O1a O 24.2675 -16.6084 22 O2a O 26.6757 -15.1950 23 C1y C 27.8854 -14.4851 24 O2x O 29.0946 -15.1718 25 C1y C 30.3025 -14.4631 26 C1y C 30.2926 -13.0626 27 C1x C 29.0835 -12.3758 28 C1y C 27.8755 -13.0846 29 C1b C 31.5468 -15.1693 30 N1a N 31.5569 -16.5953 31 O1a O 31.5060 -12.3503 32 N1a N 26.6567 -12.3923 BOND 34 1 1 2 1 2 2 3 1 3 3 4 1 4 4 5 1 5 5 6 1 6 1 6 1 7 1 7 1 #Up 8 7 8 1 9 2 9 1 #Down 10 3 10 1 #Up 11 4 11 1 #Down 12 5 12 1 #Down 13 13 12 1 #Down 14 13 14 1 15 14 15 1 16 15 16 1 17 16 17 1 18 17 18 1 19 13 18 1 20 14 19 1 #Up 21 16 20 1 #Up 22 18 21 1 #Up 23 17 22 1 #Down 24 23 22 1 #Down 25 23 24 1 26 24 25 1 27 25 26 1 28 26 27 1 29 27 28 1 30 23 28 1 31 25 29 1 #Up 32 29 30 1 33 26 31 1 #Down 34 28 32 1 #Down |