Progesterone


Entry
D00066                      Drug                                   
Name
Progesterone (JP18/USP/INN);
Crinone (TN);
Prometrium (TN)
Product
PROGESTERONE (A-S Medication Solutions), PROGESTERONE (Actavis Pharma), CRINONE (Allergan), PROGESTERONE (Bryant Ranch Prepack), PROGESTERONE (Bryant Ranch Prepack), ENDOMETRIN (Ferring Pharmaceuticals), FERRING PHARMACEUTICALS INC. (Ferring Pharmaceuticals), PROGESTERONE (Virtus Pharmaceuticals), PROMETRIUM (Virtus Pharmaceuticals)
  Generic
PROGESTERONE (A-S Medication Solutions), PROGESTERONE (A-S Medication Solutions), PROGESTERONE (A-S Medication Solutions), PROGESTERONE (Amneal Pharmaceuticals LLC), PROGESTERONE (Asclemed USA), PROGESTERONE (Asclemed USA), PROGESTERONE (Asclemed USA), PROGESTERONE (AuroMedics Pharma LLC), PROGESTERONE (Aurobindo Pharma Limited), PROGESTERONE (Bionpharma), PROGESTERONE (Bionpharma), PROGESTERONE (Bryant Ranch Prepack), PROGESTERONE (Bryant Ranch Prepack), PROGESTERONE (Bryant Ranch Prepack), PROGESTERONE (Bryant Ranch Prepack), PROGESTERONE (Bryant Ranch Prepack), PROGESTERONE (Bryant Ranch Prepack), PROGESTERONE (Bryant Ranch Prepack), PROGESTERONE (Bryant Ranch Prepack), PROGESTERONE (Denton Pharma), PROGESTERONE (Direct Rx), PROGESTERONE (Dr. Reddy's Laboratories), PROGESTERONE (Fresenius Kabi USA), PROGESTERONE (Golden State Medical Supply), PROGESTERONE (Northstar Rx LLC), PROGESTERONE (NuCare Pharmaceuticals), PROGESTERONE (NuCare Pharmaceuticals), PROGESTERONE (Proficient Rx LP), PROGESTERONE (Proficient Rx LP), PROGESTERONE (Proficient Rx LP), PROGESTERONE (Proficient Rx LP), PROGESTERONE (REMEDYREPACK), PROGESTERONE (REMEDYREPACK), PROGESTERONE (REMEDYREPACK), PROGESTERONE (RPK Pharmaceuticals), PROGESTERONE (West-Ward Pharmaceuticals Corp), PROGESTERONE (XIROMED), PROGESTERONE (Xiromed), PROGESTERONE (direct rx)
Formula
C21H30O2
Exact mass
314.2246
Mol weight
314.4617
Structure
Simcomp
Class
Hormonal agent
 DG02004  Progesterone
 DG01666  Progesterone receptor agonist
Metabolizing enzyme substrate
 DG01639  CYP2C19 substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
Same as: C00410
Therapeutic category: 2477
ATC code: G03DA04
Product: D00066<JP/US>
Product (mixture): D04459<US>
Efficacy
Menstruation disorder agent, Luteal replacement, Progesterone receptor agonist
Target
NR3C3 (PGR) [HSA:5241] [KO:K08556]
  Pathway
hsa04114  Oocyte meiosis
hsa04914  Progesterone-mediated oocyte maturation
hsa04915  Estrogen signaling pathway
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP2C19 [HSA:1557]
Interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
map07226  Progesterone, androgen and estrogen receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G03 SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
   G03D PROGESTOGENS
    G03DA Pregnen (4) derivatives
     G03DA04 Progesterone
      D00066  Progesterone (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Sex Hormones/Modifiers)
  Progestins
   Progesterone
    D00066  Progesterone (JP18/USP/INN)
 Infertility Agents
  Progesterone
   D00066  Progesterone (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   247  Estrogen and progesterone preparations
    2477  Progesterones
     D00066  Progesterone (JP18/USP/INN)
Drug groups [BR:br08330]
 Hormonal agent
  DG02004  Progesterone
   D00066  Progesterone
  DG01666  Progesterone receptor agonist
   D00066  Progesterone
 Metabolizing enzyme substrate
  DG01639  CYP2C19 substrate
   D00066  Progesterone
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D00066  Progesterone
Drug classes [BR:br08332]
 Endocrine and hormonal agent
  DG02004  Progesterone
   D00066  Progesterone
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C3 (PGR)
     D00066  Progesterone (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00066  Progesterone
  D00066  Progesterone injection
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00066
Other DBs
CAS: 57-83-0
PubChem: 7847134
ChEBI: 17026
PDB-CCD: STR[PDBj]
LigandBox: D00066
NIKKAJI: J2.329I
KCF data

ATOM        23
            1   C1y C    23.0350  -18.9936
            2   C1y C    24.2088  -19.6769
            3   C1z C    21.8554  -19.6827
            4   C1x C    23.0233  -17.6271
            5   C1y C    25.4002  -18.9819
            6   C1x C    24.1913  -21.0784
            7   C2y C    21.8554  -21.0375
            8   C1x C    20.6873  -19.0112
            9   C1a C    21.8437  -18.2754
            10  C1x C    24.2030  -16.9322
            11  C1z C    25.4060  -17.6097
            12  C1x C    27.7653  -18.9936
            13  C1x C    23.0409  -21.7092
            14  C2x C    20.6873  -21.7150
            15  C1x C    19.5194  -19.6827
            16  C1y C    26.5974  -16.9263
            17  C1a C    25.3943  -16.2081
            18  C1x C    27.7712  -17.6213
            19  C5x C    19.5194  -21.0375
            20  C5a C    26.6032  -15.5948
            21  O5x O    18.3690  -21.6975
            22  C1a C    25.3885  -14.8823
            23  O5a O    27.8121  -14.8882
BOND        26
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     3   8 1
            8     3   9 1 #Up
            9     4  10 1
            10    5  11 1
            11    5  12 1
            12    6  13 1
            13    7  14 2
            14    8  15 1
            15   11  16 1
            16   11  17 1 #Up
            17   12  18 1
            18   14  19 1
            19   16  20 1 #Up
            20   19  21 2
            21   20  22 1
            22   20  23 2
            23    7  13 1
            24   10  11 1
            25   15  19 1
            26   16  18 1