Entry

D00088                      Drug

Name

Hydrocortisone (JP18/USP/INN);
HC;
Acticort (TN);
Anusol HC (TN);
Colocort (TN);
Cortef (TN);
Hytone (TN);
Plenadren (TN)

Product

CORTENEMA (ANI Pharmaceuticals), ALKINDI (Eton Pharmaceuticals), CORTEF (Pharmacia and Upjohn Company LLC), CORTEF (REMEDYREPACK)

Generic

HYDROCORTISONE (A-S Medication Solutions), HYDROCORTISONE (A-S Medication Solutions), HYDROCORTISONE (A-S Medication Solutions), HYDROCORTISONE (A-S Medication Solutions), PROCTO-MED HC (A-S Medication Solutions), HYDROCORTISONE (A-S Medication Solutions), HYDROCORTISONE (A-S Medication Solutions), HYDROCORTISONE (ANI Pharmaceuticals), HYDROCORTISONE (ANI Pharmaceuticals), HYDROCORTISONE (Actavis Pharma), HYDROCORTISONE (Actavis Pharma), HYDROCORTISONE (American Health Packaging), HYDROCORTISONE (Amneal Pharmaceuticals of New York LLC), HYDROCORTISONE (Asclemed USA), HYDROCORTISONE (Asclemed USA), HYDROCORTISONE (Asclemed USA), HYDROCORTISONE (Bryant Ranch Prepack), HYDROCORTISONE (Bryant Ranch Prepack), HYDROCORTISONE (Bryant Ranch Prepack), HYDROCORTISONE (Bryant Ranch Prepack), HYDROCORTISONE (Bryant Ranch Prepack), HYDROCORTISONE (Bryant Ranch Prepack), HYDROCORTISONE (Bryant Ranch Prepack), HYDROCORTISONE (Bryant Ranch Prepack), HYDROCORTISONE (Bryant Ranch Prepack), HYDROCORTISONE (Bryant Ranch Prepack), HYDROCORTISONE (Bryant Ranch Prepack), HYDROCORTISONE (Bryant Ranch Prepack), HYDROCORTISONE (Bryant Ranch Prepack), HYDROCORTISONE (Bryant Ranch Prepack), HYDROCORTISONE (Bryant Ranch Prepack), HYDROCORTISONE (Bryant Ranch Prepack), HYDROCORTISONE RECTAL SUSPENSION (RETENTION) (Chartwell RX LLC), HYDROCORTISONE (Crown Laboratories), ALACORT (Crown Laboratories), HYDROCORTISONE (DIRECT RX), HYDROCORTISONE (DIRECT RX), HYDROCORTISONE (Denton Pharma), ALA-SCALP (Derm Ventures LLC), HYDROCORTISONE (E. Fougera & Co. a division of Fougera Pharmaceuticals), HYDROCORTISONE (E. Fougera & Co. a division of Fougera Pharmaceuticals), HYDROCORTISONE (E. Fougera & Co. a division of Fougera Pharmaceuticals), HYDROCORTISONE (E. Fougera & Co. a division of Fougera Pharmaceuticals), HYDROCORTISONE (Greenstone LLC), PROCTO-MED HC (LEADING PHARMA), PROCTO-MED HC (Leading Pharma), ALA-SCALP (Lifsa Drugs LLC), HYDROCORTISONE (Major Pharmaceuticals), TEXACORT (Mission Pharmacal Company), HYDROCORTISONE (NuCare Pharmaceuticals), HYDROCORTISONE (NuCare Pharmaceuticals), HYDROCORTISONE (NuCare Pharmaceuticals), HYDROCORTISONE (NuCare Pharmaceuticals), HYDROCORTISONE (NuCare Pharmaceuticals), HYDROCORTISONE (NuCare Pharmaceuticals), PROCTO-MED HC (NuCare Pharmaceuticals), HYDROCORTISONE (NuCare Pharmaceuticals), HYDROCORTISONE (PD-Rx Pharmaceuticals), HYDROCORTISONE (PD-Rx Pharmaceuticals), HYDROCORTISONE (PD-Rx Pharmaceuticals), HYDROCORTISONE (Padagis Israel Pharmaceuticals), HYDROCORTISONE (Padagis Israel Pharmaceuticals), HYDROCORTISONE (Preferred Pharmaceuticals), HYDROCORTISONE (Preferred Pharmaceuticals), HYDROCORTISONE (Proficient Rx LP), HYDROCORTISONE (Quality Care Products LLC), HYDROCORTISONE (RPK Pharmaceuticals), HYDROCORTISONE (RPK Pharmaceuticals), HYDROCORTISONE (RPK Pharmaceuticals), HYDROCORTISONE (RPK Pharmaceuticals), PROCTOZONE (Rising Pharmaceuticals), ANUSOL (Salix Pharmaceuticals), PROCTOCORT (Salix Pharmaceuticals), HYDROCORTISONE (Strides Pharma), HYDROCORTISONE (Strides Pharma), HYDROCORTISONE (Strides Pharma Science Limited), PROCTOSOL-HC (Sun Pharmaceutical Industries), HYDROCORTISONE (Taro Pharmaceuticals U.S.A.), PROCTOZONE-HC (Bryant Ranch Prepack), PROCTOZONE-HC (Bryant Ranch Prepack), PROCTOZONE-HC (NuCare Pharmaceuticals), PROCTOZONE-HC (Preferred Pharmaceuticals), PROCTOZONE-HC (Rising Pharmaceuticals)

Formula

C21H30O5

Exact mass

362.2093

Mol weight

362.4599

Structure

Simcomp

Class

Anti-inflammatory
DG01955  Corticosteroid
  DG02068  Glucocorticoid
Metabolizing enzyme substrate
DG01633  CYP3A/CYP3A4 substrate

Remark

Same as:

C00735

Therapeutic category:

2452

ATC code:

A01AC03 A07EA02 C05AA01 D07AA02 D07XA01 H02AB09 S01BA02 S01CB03 S02BA01

Chemical structure group:

DG00012

Product (DG00012):

D00088<JP/US> D00165<US> D00977<JP> D00978<JP/US> D01619<JP/US> D01886<JP/US> D02288<US>

Product (mixture):

D04699<JP> D04776<JP> D04801<JP> D08827<JP> D08828<JP> D11582<US> D11627<US> D11855<US> D12134<US>

Efficacy

Anti-inflammatory, Glucocorticoid receptor agonist

Disease

Ulcerative colitis [DS:H01466]
Primary or secondary adrenocortical insufficiency [DS:H01598]
Psoriatic arthritis [DS:H01507]
Rheumatoid arthritis [DS:H00630]
Juvenile rheumatoid arthritis [DS:H01672]
Ankylosing spondylitis [DS:H01674]
Acute gouty arthritis [DS:H01532]
Systemic lupus erythematosus [DS:H00080]
Pemphigus [DS:H01648]
Severe erythema multiforme [DS:H01695]
Stevens-Johnson syndrome [DS:H01694]
Mycosis fungoides [DS:H01463]
Psoriasis [DS:H01656]
Seborrheic dermatitis [DS:H01652]
Seasonal or perennial allergic rhinitis [DS:H01360]
Bronchial asthma [DS:H00079]
Contact dermatitis [DS:H01357]
Atopic dermatitis [DS:H01358]
Herpes zoster ophthalmicus [DS:H00366]
Optic neuritis [DS:H01717]
Pulmonary tuberculosis [DS:H00342]
Acquired (autoimmune) hemolytic anemia [DS:H01585]
Nephrotic syndrome [DS:H01657]
Ulcerative colitis [DS:H01466]
Multiple sclerosis [DS:H01490]

Target

NR3C1 (GR) [HSA:2908] [KO:K05771]

Pathway

hsa04080

Neuroactive ligand-receptor interaction

Metabolism

Enzyme: CYP3A [HSA:1576 1577 1551]

Interaction

Structure map

map07225

Glucocorticoid and mineralocorticoid receptor agonists/antagonists

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AC Corticosteroids for local oral treatment
     A01AC03 Hydrocortisone
      D00088  Hydrocortisone (JP18/USP/INN) <JP/US>
  A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
   A07E INTESTINAL ANTIINFLAMMATORY AGENTS
    A07EA Corticosteroids acting locally
     A07EA02 Hydrocortisone
      D00088  Hydrocortisone (JP18/USP/INN) <JP/US>
C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA01 Hydrocortisone
      D00088  Hydrocortisone (JP18/USP/INN) <JP/US>
D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AA Corticosteroids, weak (group I)
     D07AA02 Hydrocortisone
      D00088  Hydrocortisone (JP18/USP/INN) <JP/US>
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XA Corticosteroids, weak, other combinations
     D07XA01 Hydrocortisone
      D00088  Hydrocortisone (JP18/USP/INN) <JP/US>
H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB09 Hydrocortisone
      D00088  Hydrocortisone (JP18/USP/INN) <JP/US>
S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA02 Hydrocortisone
      D00088  Hydrocortisone (JP18/USP/INN) <JP/US>
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB03 Hydrocortisone
      D00088  Hydrocortisone (JP18/USP/INN) <JP/US>
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA01 Hydrocortisone
      D00088  Hydrocortisone (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Dermatological Agents
  Dermatitis and Pruitus Agents
   Glucocorticoids, Low Potency
    Hydrocortisone
     D00088  Hydrocortisone (JP18/USP/INN)
   Glucocorticoids, Medium Potency
    Hydrocortisone
     D00088  Hydrocortisone (JP18/USP/INN)
Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
  Hydrocortisone
   D00088  Hydrocortisone (JP18/USP/INN)
Inflammatory Bowel Disease Agents
  Glucocorticoids
   Hydrocortisone
    D00088  Hydrocortisone (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
2  Agents affecting individual organs
  24  Hormones
   245  Adrenal hormone preparations
    2452  Cortisones
     D00088  Hydrocortisone (JP18/USP/INN)
Classification of Japanese OTC drugs [BR:br08313]
Agents for integumentary system
  57 Analgesic, antipruritic, astringent, and anti-inflammatory remedies (incl. gel patches)
   D00088  Hydrocortisone (JP18/USP/INN)
Risk category of Japanese OTC drugs [BR:br08312]
Designated second-class OTC drugs
  Inorganic and organic chemicals
   Hydrocortisone
    D00088  Hydrocortisone (JP18/USP/INN)
Second-class OTC drugs
  Inorganic and organic chemicals
   Hydrocortisone
    D00088  Hydrocortisone (JP18/USP/INN)
Drug groups [BR:br08330]
Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG00012  Hydrocortisone
     D00088  Hydrocortisone
Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG00012  Hydrocortisone
    D00088  Hydrocortisone
Drug classes [BR:br08332]
Anti-inflammatory
  DG01955  Corticosteroid
   D00088  Hydrocortisone
Target-based classification of drugs [BR:br08310]
Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D00088  Hydrocortisone (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
  D00088  Hydrocortisone
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
  D00088
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
  D00088
Topical steroids potency [br08317.html]
Classification in the USA
  D00088
Rx-to-OTC switch list in the USA [br08315.html]
D00088
Drug groups [BR:br08330]
Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG00012  Hydrocortisone
Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG00012  Hydrocortisone

Other DBs

CAS:

50-23-7

PubChem:

7847156

ChEBI:

17650

PDB-CCD:

HCY[PDBj]

LigandBox:

D00088

NIKKAJI:

J1.908I

KCF data

ATOM        26
            1   C1y C    25.3915  -16.8055
            2   C1y C    24.2081  -17.4875
            3   C1z C    25.3915  -15.4414
            4   C1x C    27.7583  -16.8055
            5   C1y C    23.0247  -16.8055
            6   C1x C    24.1965  -18.8575
            7   C1z C    26.5809  -14.7535
            8   C1x C    24.2081  -14.7535
            9   C1a C    25.3858  -14.0713
            10  C1x C    27.7583  -15.4414
            11  C1z C    21.8356  -17.4875
            12  C1y C    23.0247  -15.4414
            13  C1x C    23.0247  -19.5395
            14  C5a C    26.5866  -13.3893
            15  C2y C    21.8356  -18.8575
            16  C1x C    20.6579  -16.8055
            17  C1a C    21.8239  -16.1233
            18  O1a O    21.8356  -14.7535
            19  C1b C    27.7643  -12.7072
            20  O5a O    25.3975  -12.7072
            21  C2x C    20.6579  -19.5395
            22  C1x C    19.4687  -17.4875
            23  O1a O    28.9534  -13.3951
            24  C5x C    19.4687  -18.8575
            25  O5x O    18.2853  -19.5395
            26  O1a O    27.9332  -14.3911
BOND        29
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     3   8 1
            8     3   9 1 #Up
            9     4  10 1
            10    5  11 1
            11    5  12 1
            12    6  13 1
            13    7  14 1 #Up
            14   11  15 1
            15   11  16 1
            16   11  17 1 #Up
            17   12  18 1 #Up
            18   14  19 1
            19   14  20 2
            20   15  21 2
            21   16  22 1
            22   19  23 1
            23   21  24 1
            24   24  25 2
            25    7  10 1
            26    8  12 1
            27   13  15 1
            28   22  24 1
            29    7  26 1 #Down