Scopolamine

Entry

D00138                      Drug

Name

Scopolamine (INN);
Transderm scop (TN)

Product

TRANSDERM SCOP (Baxter Healthcare Corporation)

Generic

SCOPOLAMINE TRANDERMAL SYSTEM (Bryant Ranch Prepack), SCOPOLAMINE TRANDERMAL SYSTEM (Bryant Ranch Prepack), SCOPOLAMINE TRANDERMAL SYSTEM (Bryant Ranch Prepack), SCOPOLAMINE TRANDERMAL SYSTEM (Padagis Israel Pharmaceuticals), SCOPOLAMINE (A-S Medication Solutions), SCOPOLAMINE (Actavis Pharma), SCOPOLAMINE (Ingenus Pharmaceuticals), SCOPOLAMINE (Mylan Pharmaceuticals)

Formula

C17H21NO4

Exact mass

303.1471

Mol weight

303.3529

Structure

Simcomp

Source

Atropa belladonna [TAX:33113]

Class

Neuropsychiatric agent
DG01491 Muscarinic cholinergic receptor antagonist
Gastrointestinal agent
DG01762 Antiemetic

Remark

Same as:

C01851

ATC code:

A04AD01 N05CM05 S01FA02

Chemical structure group:

DG00065

Product (DG00065):

D00138<US> D02071<JP>

Efficacy

Antiemetic, Mydriatic, Muscarinic acetylcholine receptor antagonist

Comment

Tropane derivative

Target

CHRM [HSA:1128 1129 1131 1132 1133] [KO:K04129 K04130 K04131 K04132 K04133]

Pathway

hsa04024

cAMP signaling pathway

hsa04080

Neuroactive ligand-receptor interaction

hsa04725

Cholinergic synapse

Interaction

Structure map

map07220

Cholinergic and anticholinergic drugs

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
  A04 ANTIEMETICS AND ANTINAUSEANTS
   A04A ANTIEMETICS AND ANTINAUSEANTS
    A04AD Other antiemetics
     A04AD01 Scopolamine
      D00138  Scopolamine (INN) <US>
N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05C HYPNOTICS AND SEDATIVES
    N05CM Other hypnotics and sedatives
     N05CM05 Scopolamine
      D00138  Scopolamine (INN) <US>
S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01F MYDRIATICS AND CYCLOPLEGICS
    S01FA Anticholinergics
     S01FA02 Scopolamine
      D00138  Scopolamine (INN) <US>
USP drug classification [BR:br08302]
Antiemetics
  Antiemetics, Other
   Scopolamine
    D00138  Scopolamine (INN)
Gastrointestinal Agents
  Antispasmodics, Gastrointestinal
   Scopolamine
    D00138  Scopolamine (INN)
Risk category of Japanese OTC drugs [BR:br08312]
Second-class OTC drugs
  Inorganic and organic chemicals
   Scopolamine
    D00138  Scopolamine (INN)
Drug groups [BR:br08330]
Neuropsychiatric agent
  DG01491  Muscarinic cholinergic receptor antagonist
   DG00065  Scopolamine
    D00138  Scopolamine
Gastrointestinal agent
  DG01762  Antiemetic
   DG00065  Scopolamine
    D00138  Scopolamine
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    CHRM
     D00138  Scopolamine (INN) <US>
Drug groups [BR:br08330]
Neuropsychiatric agent
  DG01491  Muscarinic cholinergic receptor antagonist
   DG00065  Scopolamine
Gastrointestinal agent
  DG01762  Antiemetic
   DG00065  Scopolamine

Other DBs

CAS:

51-34-3

PubChem:

7847206

ChEBI:

16794 182414

LigandBox:

D00138

NIKKAJI:

J47.151H

KCF data

ATOM        22
            1   C1y C    27.2691  -18.1297
            2   C1y C    27.5838  -16.9522
            3   C1y C    28.4522  -17.8207
            4   O2x O    26.2433  -16.7249
            5   C1y C    28.7612  -16.6375
            6   N1y N    27.5314  -15.3494
            7   C1x C    30.3057  -17.8264
            8   C1x C    30.0493  -16.6433
            9   C1a C    27.4790  -13.9915
            10  C1y C    31.3199  -18.3685
            11  O7a O    32.3631  -19.2836
            12  C7a C    33.7631  -19.2836
            13  O6a O    34.4427  -20.4609
            14  C1c C    34.4721  -18.0566
            15  C8y C    35.8400  -18.0572
            16  C8x C    36.5407  -19.2720
            17  C8x C    37.9407  -19.2726
            18  C8x C    38.6412  -18.0604
            19  C8x C    37.9405  -16.8456
            20  C8x C    36.5405  -16.8451
            21  C1b C    33.7664  -16.8327
            22  O1a O    34.4744  -15.6081
BOND        25
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     3   6 1
            6     3   7 1
            7     5   8 1
            8     6   9 1
            9     7  10 1
            10   10  11 1 #Down
            11    2   4 1
            12    5   6 1
            13    8  10 1
            14   11  12 1
            15   12  13 2
            16   12  14 1
            17   14  15 1
            18   15  16 2
            19   16  17 1
            20   17  18 2
            21   18  19 1
            22   19  20 2
            23   15  20 1
            24   14  21 1 #Down
            25   21  22 1