Mefenamic acid


Entry
D00151                      Drug                                   
Name
Mefenamic acid (JP18/USP/INN);
Ponstel (TN)
Product
  Generic
MEFENAMIC ACID (Belcher Pharmaceuticals), MEFENAMIC ACID (Lupin Pharmaceuticals), MEFENAMIC ACID (Micro Labs Limited), MEFENAMIC ACID (Misemer Pharmaceuticals)
Formula
C15H15NO2
Exact mass
241.1103
Mol weight
241.2851
Structure
Simcomp
Class
Anti-inflammatory
 DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
  DG01911  Anti-inflammatory drug, fenamic acid derivatives
Metabolizing enzyme substrate
 DG01642  CYP2C9 substrate
Remark
Same as: C02168
Therapeutic category: 1141
ATC code: M01AG01
Product: D00151<JP/US>
Efficacy
Analgesic, Anti-inflammatory, Antipyretic, COX inhibitor
Comment
Aniline derivative, Fenamic acid derivative
Target
PTGS1 (COX1) [HSA:5742] [KO:K00509]
PTGS2 (COX2) [HSA:5743] [KO:K11987]
  Pathway
hsa00590  Arachidonic acid metabolism
Metabolism
Enzyme: CYP2C9 [HSA:1559]
Interaction
Structure map
map07110  Benzoic acid family
map07219  Cyclooxygenase inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 M MUSCULO-SKELETAL SYSTEM
  M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
   M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
    M01AG Fenamates
     M01AG01 Mefenamic acid
      D00151  Mefenamic acid (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Analgesics
  Nonsteroidal Anti-inflammatory Drugs
   Mefenamic Acid
    D00151  Mefenamic acid (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   114  Antipyretics and analgesics, anti-inflammatory agents
    1141  Anilines
     D00151  Mefenamic acid (JP18/USP/INN)
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
   DG01911  Anti-inflammatory drug, fenamic acid derivatives
    D00151  Mefenamic acid
 Metabolizing enzyme substrate
  DG01642  CYP2C9 substrate
   D00151  Mefenamic acid
Drug classes [BR:br08332]
 Anti-inflammatory
  DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
   D00151  Mefenamic acid
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Prostaglandin synthase
    PTGS1 (COX1)
     D00151  Mefenamic acid (JP18/USP/INN) <JP/US>
    PTGS2 (COX2)
     D00151  Mefenamic acid (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00151  Mefenamic acid
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00151
Other DBs
CAS: 61-68-7
PubChem: 7847219
ChEBI: 6717
PDB-CCD: ID8[PDBj]
LigandBox: D00151
NIKKAJI: J2.344B
KCF data

ATOM        18
            1   C8x C    16.5885  -16.4952
            2   C8y C    16.5885  -15.0954
            3   C8y C    15.3763  -14.3954
            4   C8x C    14.1639  -15.0954
            5   C8x C    14.1639  -16.4952
            6   C8x C    15.3763  -17.1951
            7   C6a C    15.3763  -12.9956
            8   O6a O    14.1633  -12.2953
            9   O6a O    16.5878  -12.2961
            10  N1b N    17.8008  -14.3954
            11  C8y C    19.0137  -15.0958
            12  C8x C    19.0137  -16.4952
            13  C8x C    20.2260  -17.1951
            14  C8x C    21.4384  -16.4952
            15  C8y C    21.4384  -15.0958
            16  C8y C    20.2260  -14.3958
            17  C1a C    20.2261  -12.9956
            18  C1a C    22.6530  -14.3944
BOND        19
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     3   7 1
            8     7   8 2
            9     7   9 1
            10    2  10 1
            11   10  11 1
            12   11  12 1
            13   12  13 2
            14   13  14 1
            15   14  15 2
            16   15  16 1
            17   11  16 2
            18   16  17 1
            19   15  18 1