Entry
Name
Alprostadil (JP18/USP/INN); Prostin VR pediatric (TN); Caverject (TN); Edex (TN); Muse (TN)
Product
EDEX (Endo Pharmaceuticals), MUSE (Meda Pharmaceuticals), CAVERJECT IMPULSE (Pharmacia and Upjohn Company LLC), CAVERJECT (Pharmacia and Upjohn Company LLC), PROSTIN (Pharmacia and Upjohn Company LLC), CAVERJECT IMPULSE (U.S. Pharmaceuticals)
Generic
ALPROSTADIL (Teva Parenteral Medicines)
Formula
C20H34O5
Exact mass
354.2406
Mol weight
354.481
Structure
Mol file KCF file DB search
Simcomp
Neighbor
Class
Hormonal agent
DG01961 Prostaglandin derivative
DG01611 Prostaglandin E1 derivative
Remark
Therapeutic category: 2190
ATC code: C01EA01 G04BE01
Chemical structure group: DG00239
Product (DG00239): D00180<JP/US> D02705<JP>
Efficacy
Vasodilator, Prostaglandin E1 receptor agonist
Disease
Pulmonary atresia [DS:H01802 H01803] Tricuspid atresia [DS:H01785] Tetralogy of Fallot [DS:H00549]
Comment
Prostaglandin derivative
Treatment of erectile dysfunction
Target
PTGER1 [HSA:5731] [KO:K04258]
Pathway
hsa04020 Calcium signaling pathway
hsa04080 Neuroactive ligand-receptor interaction
Interaction
DDI search
Structure map
map07228 Eicosanoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C01 CARDIAC THERAPY
C01E OTHER CARDIAC PREPARATIONS
C01EA Prostaglandins
C01EA01 Alprostadil
D00180 Alprostadil (JP18/USP/INN) <JP/US>
G GENITO URINARY SYSTEM AND SEX HORMONES
G04 UROLOGICALS
G04B UROLOGICALS
G04BE Drugs used in erectile dysfunction
G04BE01 Alprostadil
D00180 Alprostadil (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Hormonal Agents, Stimulant/Replacement/Modifying (Prostaglandins)
Alprostadil
D00180 Alprostadil (JP18/USP/INN)
Sexual Disorder Agents
Sexual Disorder Agents (Male)
Alprostadil
D00180 Alprostadil (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
21 Cardiovascular agents
219 Miscellaneous
2190 Miscellaneous
D00180 Alprostadil (JP18/USP/INN)
Drug groups [BR:br08330]
Hormonal agent
DG01961 Prostaglandin derivative
DG01611 Prostaglandin E1 derivative
DG00239 Alprostadil
D00180 Alprostadil
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Prostaglandin
PTGER1
D00180 Alprostadil (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00180 Alprostadil
D00180 Alprostadil injection
Drug groups [BR:br08330]
Hormonal agent
DG01961 Prostaglandin derivative
DG01611 Prostaglandin E1 derivative
DG00239 Alprostadil
BRITE hierarchy
Other DBs
KCF data
Show ATOM 25
1 C1y C 23.5830 -17.4951
2 C1y C 23.5770 -18.9049
3 C5x C 22.2430 -17.0640
4 C1b C 24.7947 -16.7901
5 C1y C 22.2604 -19.3360
6 C2b C 24.7947 -19.5983
7 C1x C 21.4215 -18.2057
8 O5x O 21.8061 -15.7356
9 C1b C 26.0066 -17.4951
10 O1a O 21.8409 -20.6703
11 C2b C 26.0066 -18.9049
12 C1b C 27.2243 -16.7901
13 C1c C 27.2243 -19.5983
14 C1b C 28.4301 -17.4951
15 C1b C 28.4360 -18.9049
16 O1a O 27.2243 -21.0023
17 C1b C 29.6477 -16.7901
18 C1b C 29.6477 -19.5983
19 C1b C 30.8654 -17.4951
20 C1b C 30.8654 -18.9049
21 C6a C 32.0773 -16.7901
22 C1b C 32.0773 -19.5983
23 O6a O 33.2890 -17.5009
24 O6a O 32.0306 -15.4268
25 C1a C 33.2950 -18.9049
BOND 25
1 1 2 1
2 1 3 1
3 1 4 1 #Down
4 2 5 1
5 2 6 1 #Up
6 3 7 1
7 3 8 2
8 4 9 1
9 5 10 1 #Down
10 6 11 2
11 9 12 1
12 11 13 1
13 12 14 1
14 13 15 1
15 13 16 1 #Down
16 14 17 1
17 15 18 1
18 17 19 1
19 18 20 1
20 19 21 1
21 20 22 1
22 21 23 1
23 21 24 2
24 22 25 1
25 5 7 1