Entry

D00182                      Drug

Name

Norethindrone (USP);
Norethisterone (JP18);
Camila (TN);
Micronor (TN);
Primolut-N (TN)

Product

Generic

NORLYDA (A-S Medication Solutions), NORA BE (Actavis Pharma), LYZA (Afaxys Pharma LLC), LYLEQ (Afaxys Pharma), NORLYDA (Amneal Pharmaceuticals NY LLC), INCASSIA (Aurobindo Pharma Limited), NORETHINDRONE (Glenmark Pharmaceuticals), HEATHER (Glenmark Pharmaceuticals), NORETHINDRONE (Lupin Pharmaceuticals), JENCYCLA (Lupin Pharmaceuticals), NORETHINDRONE (Lupin Pharmaceuticals), JENCYCLA (Lupin Pharmaceuticals), ERRIN (Mayne Pharma), CAMILA (Mayne Pharma), NORETHINDRONE (Mylan Pharmaceuticals), NORETHINDRONE (Mylan Pharmaceuticals), SHAROBEL (Northstar Rx LLC), DEBLITANE (Northstar Rx LLC), ERRIN (Proficient Rx LP), NORETHINDRONE (Proficient Rx LP), NORETHINDRONE (REMEDYREPACK), LYLEQ (RPK Pharmaceuticals), TULANA (RPK Pharmaceuticals)

Formula

C20H26O2

Exact mass

298.1933

Mol weight

298.4192

Structure

Simcomp

Class

Hormonal agent
DG02004 Progesterone
DG01666 Progesterone receptor agonist

Remark

Same as:

C05028

Therapeutic category:

2479

ATC code:

G03AC01 G03DC02

Chemical structure group:

DG00456

Product (DG00456):

D00182<JP/US> D00953<US>

Product (mixture):

D04483<JP/US> D09188<JP/US>

Efficacy

Contraceptive, Progesterone receptor agonist

Comment

Progestin, Estren derivative

Target

NR3C3 (PGR) [HSA:5241] [KO:K08556]

Pathway

hsa04114

Oocyte meiosis

hsa04914

Progesterone-mediated oocyte maturation

hsa04915

Estrogen signaling pathway

Interaction

Structure map

map07226

Progesterone, androgen and estrogen receptor agonists/antagonists

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
G GENITO URINARY SYSTEM AND SEX HORMONES
  G03 SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
   G03A HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE
    G03AC Progestogens
     G03AC01 Norethisterone
      D00182  Norethindrone (USP) <JP/US>
   G03D PROGESTOGENS
    G03DC Estren derivatives
     G03DC02 Norethisterone
      D00182  Norethindrone (USP) <JP/US>
USP drug classification [BR:br08302]
Contraceptives
  Oral Progestins
   Norethindrone
    D00182  Norethindrone (USP)
Hormonal Agents, Stimulant/Replacement/Modifying (Sex Hormones/Modifiers)
  Progestins
   Norethindrone
    D00182  Norethindrone (USP)
Therapeutic category of drugs in Japan [BR:br08301]
2  Agents affecting individual organs
  24  Hormones
   247  Estrogen and progesterone preparations
    2479  Others
     D00182  Norethindrone (USP); Norethisterone (JP18)
Drug groups [BR:br08330]
Hormonal agent
  DG02004  Progesterone
   DG00456  Norethisterone
    D00182  Norethindrone
  DG01666  Progesterone receptor agonist
   DG00456  Norethisterone
    D00182  Norethindrone
Drug classes [BR:br08332]
Endocrine and hormonal agent
  DG02004  Progesterone
   D00182  Norethindrone
Target-based classification of drugs [BR:br08310]
Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C3 (PGR)
     D00182  Norethindrone (USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
  D00182  Norethisterone
Drug groups [BR:br08330]
Hormonal agent
  DG02004  Progesterone
   DG00456  Norethisterone
  DG01666  Progesterone receptor agonist
   DG00456  Norethisterone

Other DBs

CAS:

68-22-4

PubChem:

7847250

ChEBI:

7627

PDB-CCD:

NDR[PDBj]

LigandBox:

D00182

NIKKAJI:

J1.416H

KCF data

ATOM        22
            1   C1y C    26.8452  -17.3412
            2   C1z C    26.8512  -15.9656
            3   C1y C    25.6547  -18.0321
            4   C1x C    29.2262  -17.3473
            5   C1z C    28.0417  -15.2747
            6   C1x C    25.6484  -15.2810
            7   C1a C    26.8019  -14.4420
            8   C1y C    24.4702  -17.3536
            9   C1x C    25.5970  -19.4015
            10  C1x C    29.2324  -15.9718
            11  C3b C    29.1954  -14.5962
            12  O1a O    28.0357  -13.5161
            13  C1x C    24.5279  -15.9779
            14  C1y C    23.2921  -18.0384
            15  C1x C    24.4826  -20.0800
            16  C3a C    30.3488  -13.9116
            17  C2y C    23.2921  -19.3954
            18  C1x C    22.1200  -17.3720
            19  C2x C    22.1200  -20.0800
            20  C1x C    20.9542  -18.0384
            21  C5x C    20.9542  -19.3954
            22  O5x O    19.7884  -20.0616
BOND        25
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     2   7 1 #Up
            7     3   8 1
            8     3   9 1
            9     4  10 1
            10    5  11 1 #Down
            11    5  12 1 #Up
            12    6  13 1
            13    8  14 1
            14    9  15 1
            15   11  16 3
            16   14  17 1
            17   14  18 1
            18   17  19 2
            19   18  20 1
            20   19  21 1
            21   21  22 2
            22    5  10 1
            23    8  13 1
            24   15  17 1
            25   20  21 1