| Entry |
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|---|---|---|---|---|---|---|---|---|---|---|---|
| Name | Dactinomycin (USP); Actinomycin D (JP18); Cosmegen (TN) | ||||||||||
| Product | COSMEGEN (RECORDATI RARE DISEASES) | ||||||||||
| Generic | DACTINOMYCIN (AuroMedics Pharma LLC), DACTINOMYCIN (AuroMedics Pharma LLC), DACTINOMYCIN (Hisun Pharmaceuticals USA), DACTINOMYCIN (Meitheal Pharmaceuticals), DACTINOMYCIN (Mylan Institutional LLC), DACTINOMYCIN (Mylan Institutional LLC), DACTINOMYCIN (Prasco Laboratories), DACTINOMYCIN (XGen Pharmaceuticals DJB) | ||||||||||
| Formula | C62H86N12O16 | ||||||||||
| Exact mass | 1254.6285 | ||||||||||
| Mol weight | 1255.417 | ||||||||||
| Structure |  | ||||||||||
| Simcomp | |||||||||||
| Sequence | 0 4MHA 1 Thr 2 D-Val 3 Pro 4 Sar 5 Val (Cyclization: 1-5, Dimer) | ||||||||||
| Type | NRP | ||||||||||
| Source | Streptomyces parvullus [TAX:146923] | ||||||||||
| Remark |
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| Efficacy | Antineoplastic | ||||||||||
| Disease | Wilms tumor [DS:H02301] Rhabdomyosarcoma [DS:H00037] Ewings sarcoma [DS:H00035] Testicular cancer [DS:H00023] Solid malignancies [DS:H02421] | ||||||||||
| Target | RNA polymerase | ||||||||||
| Interaction | |||||||||||
| Structure map |
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| Other map |
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| Brite | Anatomical Therapeutic Chemical (ATC) classification [BR:br08303] L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS L01 ANTINEOPLASTIC AGENTS L01D CYTOTOXIC ANTIBIOTICS AND RELATED SUBSTANCES L01DA Actinomycines L01DA01 Dactinomycin D00214 Dactinomycin (USP) <JP/US> Therapeutic category of drugs in Japan [BR:br08301] 4 Agents affecting cellular function 42 Antineoplastics 423 Antibiotics 4233 Actinomycin D D00214 Dactinomycin (USP); Actinomycin D (JP18) Drugs listed in the Japanese Pharmacopoeia [BR:br08311] Chemicals D00214 Actinomycin D | ||||||||||
| Other DBs |
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| KCF data | ATOM 90 1 C8y C 25.6418 -18.7249 2 C8y C 25.6541 -17.4511 3 N5x N 24.5349 -19.3619 4 C8y C 26.7301 -19.3682 5 O2x O 24.5473 -16.8017 6 C8y C 26.7612 -16.8265 7 C8y C 23.4279 -18.7188 8 C8y C 27.8433 -18.7373 9 C5a C 26.7240 -20.6481 10 C8y C 23.4403 -17.4324 11 C8y C 27.8619 -17.4696 12 C1a C 26.7673 -15.5587 13 C8y C 22.3395 -19.3558 14 N1a N 28.9440 -19.3927 15 N1b N 27.8248 -21.2974 16 O5a O 25.6109 -21.2727 17 C8y C 22.3395 -16.7956 18 O5x O 28.9625 -16.8388 19 C8x C 21.2326 -18.7188 20 C5a C 22.3395 -20.6357 21 C1y C 27.8124 -22.5714 22 C8x C 21.2326 -17.4324 23 C1a C 22.3395 -15.5216 24 N1b N 21.2326 -21.2727 25 O5a O 23.4403 -21.2666 26 C5x C 26.6993 -23.2022 27 C1y C 28.9132 -23.2206 28 C1y C 21.2326 -22.5528 29 N1x N 26.6540 -28.2854 30 O5x O 25.6046 -22.5528 31 O7x O 30.0263 -22.5899 32 C1a C 28.9069 -24.4946 33 C5x C 22.3395 -23.1835 34 C1y C 20.1258 -23.1898 35 C1y C 28.3999 -28.9841 36 C7x C 31.1208 -23.2393 37 N1x N 22.3334 -28.2235 38 O5x O 23.4465 -22.5467 39 O7x O 19.0311 -22.5591 40 C1a C 20.1258 -24.4699 41 C5x C 30.3416 -28.2667 42 C1c C 28.3999 -30.2209 43 C1y C 32.2339 -22.6147 44 O6a O 31.1784 -24.5194 45 C1y C 21.0286 -28.9285 46 C7x C 17.9180 -23.1959 47 N1y N 32.2524 -29.1139 48 O5x O 30.3416 -26.9867 49 C1a C 27.2868 -30.8579 50 C1a C 29.5005 -30.8579 51 N1y N 33.3347 -23.2578 52 C1c C 32.1763 -21.3346 53 C5x C 18.7715 -28.2854 54 C1c C 21.0286 -30.2086 55 C1y C 16.8112 -22.5652 56 O6a O 17.9180 -24.4760 57 C1y C 33.2913 -28.3718 58 C1x C 32.6358 -30.3321 59 C5x C 33.3223 -24.5317 60 C1a C 34.4478 -22.6270 61 C1a C 33.3655 -20.7099 62 C1a C 31.1516 -20.6852 63 N1y N 16.7493 -29.0583 64 O5x O 18.7715 -26.9929 65 C1a C 19.9217 -30.8456 66 C1a C 22.1354 -30.8456 67 N1y N 15.7104 -23.2022 68 C1c C 16.8049 -21.2851 69 C1x C 34.3178 -29.1326 70 C5x C 33.3036 -27.0856 71 C1x C 33.9098 -30.3445 72 C1x C 34.4231 -25.1809 73 O5x O 32.2153 -25.1625 74 C1y C 15.7165 -28.3162 75 C1x C 16.3598 -30.2765 76 C5x C 15.6465 -24.4822 77 C1a C 14.6034 -22.5714 78 C1a C 17.9180 -20.6481 79 C1a C 15.7041 -20.6481 80 N1y N 34.4168 -26.4673 81 O5x O 32.2092 -26.4426 82 C1x C 14.6776 -29.0583 83 C5x C 15.7165 -27.0361 84 C1x C 15.0797 -30.2765 85 C1x C 14.6034 -25.1192 86 O5x O 16.8112 -25.1130 87 C1a C 35.5238 -27.1165 88 N1y N 14.6096 -26.3992 89 O5x O 16.8112 -26.3931 90 C1a C 13.5089 -27.0424 BOND 96 1 1 2 1 2 1 3 2 3 1 4 1 4 2 5 1 5 2 6 2 6 3 7 1 7 4 8 2 8 4 9 1 9 5 10 1 10 6 11 1 11 6 12 1 12 7 13 2 13 8 14 1 14 9 15 1 15 9 16 2 16 10 17 2 17 11 18 2 18 13 19 1 19 13 20 1 20 15 21 1 21 17 22 1 22 17 23 1 23 20 24 1 24 20 25 2 25 21 26 1 26 21 27 1 27 24 28 1 28 26 29 1 29 26 30 2 30 27 31 1 31 27 32 1 32 28 33 1 33 28 34 1 34 29 35 1 35 31 36 1 36 33 37 1 37 33 38 2 38 34 39 1 39 34 40 1 40 35 41 1 41 35 42 1 42 36 43 1 43 36 44 2 44 37 45 1 45 39 46 1 46 41 47 1 47 41 48 2 48 42 49 1 49 42 50 1 50 43 51 1 51 43 52 1 52 45 53 1 53 45 54 1 54 46 55 1 55 46 56 2 56 47 57 1 57 47 58 1 58 51 59 1 59 51 60 1 60 52 61 1 61 52 62 1 62 53 63 1 63 53 64 2 64 54 65 1 65 54 66 1 66 55 67 1 67 55 68 1 68 57 69 1 69 57 70 1 70 58 71 1 71 59 72 1 72 59 73 2 73 63 74 1 74 63 75 1 75 67 76 1 76 67 77 1 77 68 78 1 78 68 79 1 79 70 80 1 80 70 81 2 81 74 82 1 82 74 83 1 83 75 84 1 84 76 85 1 85 76 86 2 86 80 87 1 87 83 88 1 88 83 89 2 89 88 90 1 90 7 10 1 91 8 11 1 92 19 22 2 93 69 71 1 94 72 80 1 95 82 84 1 96 85 88 1 |