Entry

D00217                      Drug

Name

Acetaminophen (JP18/USP);
Paracetamol (INN);
Tylenol (TN)

Product

ACETAMINOPHEN (B. Braun Medical), ACETAMINOPHEN (Fresenius Kabi USA), ACETAMINOPHEN (Hikma Pharmaceuticals USA), OFIRMEV (ACETAMINOPHEN) (HF Acquisition Co LLC)

Generic

ACETAMINOPHEN (AuroMedics Pharma LLC), ACETAMINOPHEN (Baxter Healthcare Corporation), GOOD NEIGHBOR PHARMACY PAIN RELIEF (Bryant Ranch Prepack), ACETAMINOPHEN (HF Acquisition Co LLC), ACETAMINOPHEN (Hikma Pharmaceuticals USA), ACETAMINOPHEN (Mylan Institutional LLC), ACETAMINOPHEN (Sandoz), ACETAMINOPHEN (Sandoz), ACETAMINOPHEN (Solupharm Pharmazeutische Erzeugnisse GmbH)

Formula

C8H9NO2

Exact mass

151.0633

Mol weight

151.1626

Structure

Simcomp

Class

Anti-inflammatory
DG01981 Anilide derivative, anti-inflammatory

Remark

Same as:

C06804

Therapeutic category:

1141

ATC code:

N02BE01

Product:

D00217<JP/US>

Product (mixture):

D00846<US> D02146<US> D02153<US> D03976<JP> D04044<JP> D04046<JP> D08695<JP> D09999<JP/US> D11561<US> D11628<US> D11850<US> D11851<US> D12295<US>

Efficacy

Analgesic, Antipyretic

Comment

Aniline derivative, Anilide derivative

Target

PTGS1 (COX1) [HSA:5742] [KO:K00509]
PTGS2 (COX2) [HSA:5743] [KO:K11987]

Pathway

hsa00590

Arachidonic acid metabolism

Interaction

Structure map

map07048

Antimigraines

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
  N02 ANALGESICS
   N02B OTHER ANALGESICS AND ANTIPYRETICS
    N02BE Anilides
     N02BE01 Paracetamol
      D00217  Acetaminophen (JP18/USP) <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   114  Antipyretics and analgesics, anti-inflammatory agents
    1141  Anilines
     D00217  Acetaminophen (JP18/USP); Paracetamol (INN)
Classification of Japanese OTC drugs [BR:br08313]
Agents for nervous and sensory systems
  01 Cold remedy (oral use)
   D00217  Acetaminophen (JP18/USP)
  03 Antipyretic analgesic agents
   D00217  Acetaminophen (JP18/USP)
Risk category of Japanese OTC drugs [BR:br08312]
Second-class OTC drugs
  Inorganic and organic chemicals
   Acetaminophen
    D00217  Acetaminophen (JP18/USP)
Drug groups [BR:br08330]
Anti-inflammatory
  DG01981  Anilide derivative, anti-inflammatory
   D00217  Acetaminophen
Target-based classification of drugs [BR:br08310]
Enzymes
  Oxidoreductases (EC1)
   Prostaglandin synthase
    PTGS1 (COX1)
     D00217  Acetaminophen (JP18/USP) <JP/US>
    PTGS2 (COX2)
     D00217  Acetaminophen (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
  D00217  Acetaminophen
Prodrugs [br08324.html]
D00217
Rx-to-OTC switch list in the USA [br08315.html]
D00217

Other DBs

CAS:

103-90-2

PubChem:

7847284

ChEBI:

46195

PDB-CCD:

TYL[PDBj]

LigandBox:

D00217

NIKKAJI:

J4.025H

KCF data

ATOM        11
            1   C8y C    21.1806  -16.6437
            2   C8x C    21.1806  -18.0466
            3   C8x C    19.9699  -15.9511
            4   N1b N    22.3914  -15.9511
            5   C8x C    19.9699  -18.7509
            6   C8x C    18.7534  -16.6437
            7   C5a C    23.6080  -16.6496
            8   C8y C    18.7534  -18.0466
            9   C1a C    24.8186  -15.9511
            10  O5a O    23.6020  -18.0466
            11  O1a O    17.5425  -18.7509
BOND        11
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 2
            5     3   6 1
            6     4   7 1
            7     5   8 1
            8     7   9 1
            9     7  10 2
            10    8  11 1
            11    6   8 2