Entry

D00251                      Drug

Name

Captopril (JP18/USP/INN);
Apopril (TN);
Capoten (TN)

Product

Generic

CAPTOPRIL (A-S Medication Solutions), CAPTOPRIL (A-S Medication Solutions), CAPTOPRIL (AMICI PHARMACEUTICALS LLC), CAPTOPRIL (Ajanta Pharma USA), CAPTOPRIL (American Health Packaging), CAPTOPRIL (Bryant Ranch Prepack), CAPTOPRIL (Bryant Ranch Prepack), CAPTOPRIL (Bryant Ranch Prepack), CAPTOPRIL (Bryant Ranch Prepack), CAPTOPRIL (Bryant Ranch Prepack), CAPTOPRIL (Bryant Ranch Prepack), CAPTOPRIL (Bryant Ranch Prepack), CAPTOPRIL (Camber Pharmaceuticals), CAPTOPRIL (Golden State Medical Supply), CAPTOPRIL (Hikma Pharmaceuticals USA), CAPTOPRIL (Major Pharmaceuticals), CAPTOPRIL (Major Pharmaceuticals), CAPTOPRIL (PD-Rx Pharmaceuticals), CAPTOPRIL (REMEDYREPACK), CAPTOPRIL (SANDOZ), CAPTOPRIL (Windlas Biotech Limited)

Formula

C9H15NO3S

Exact mass

217.0773

Mol weight

217.2853

Structure

Simcomp

Class

Cardiovascular agent
DG01925  Renin-angiotensin system inhibitor
  DG01501  Angiotensin-converting enzyme inhibitor
DG03231  Antihypertensive
  DG01501  Angiotensin-converting enzyme inhibitor

Remark

Same as:

C06867

Therapeutic category:

2144

ATC code:

C09AA01

Product:

D00251<JP/US>

Efficacy

Antihypertensive, Angiotensin-converting enzyme inhibitor

Disease

Hypertension [DS:H01633]
Diabetic Nephropathy [DS:H01456]

Target

ACE (CD143) [HSA:1636] [KO:K01283]

Pathway

hsa04614

Renin-angiotensin system

Interaction

Structure map

map07217

Renin-angiotensin system inhibitors

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
  C09 AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
   C09A ACE INHIBITORS, PLAIN
    C09AA ACE inhibitors, plain
     C09AA01 Captopril
      D00251  Captopril (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Cardiovascular Agents
  Angiotensin-converting Enzyme (ACE) Inhibitors
   Captopril
    D00251  Captopril (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
2  Agents affecting individual organs
  21  Cardiovascular agents
   214  Antihypertensives
    2144  Angiotensin converting enzyme inhibitors
     D00251  Captopril (JP18/USP/INN)
Drug groups [BR:br08330]
Cardiovascular agent
  DG01925  Renin-angiotensin system inhibitor
   DG01501  Angiotensin-converting enzyme inhibitor
    D00251  Captopril
  DG03231  Antihypertensive
   DG01501  Angiotensin-converting enzyme inhibitor
    D00251  Captopril
Drug classes [BR:br08332]
Cardiovascular agent
  DG01501  Angiotensin-converting enzyme inhibitor
   D00251  Captopril
  DG03231  Antihypertensive
   D00251  Captopril
Target-based classification of drugs [BR:br08310]
Enzymes
  Hydrolases (EC3)
   Peptidyl-dipeptidases
    ACE (CD143)
     D00251  Captopril (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
  D00251  Captopril
Prodrugs [br08324.html]
D00251

Other DBs

CAS:	62571-86-2

PubChem:

7847317

ChEBI:

3380

PDB-CCD:

X8Z[PDBj]

LigandBox:

D00251

NIKKAJI:

J3.203D

KCF data

ATOM        14
            1   C1x C    30.3001  -29.3105
            2   C1x C    30.7108  -30.6489
            3   C1x C    32.1107  -30.6718
            4   C1y C    32.5650  -29.3476
            5   N1y N    31.4460  -28.5062
            6   C5a C    31.4460  -27.1062
            7   O5a O    32.6533  -26.4091
            8   C1c C    30.2145  -26.3954
            9   C1b C    29.0237  -27.0832
            10  S1a S    27.8339  -26.3964
            11  C6a C    33.8944  -28.9394
            12  O6a O    35.2472  -29.5220
            13  O6a O    33.8637  -27.5503
            14  C1a C    30.2142  -24.9902
BOND        14
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     1   5 1
            6     5   6 1
            7     6   7 2
            8     6   8 1
            9     8   9 1
            10    9  10 1
            11    4  11 1 #Down
            12   11  12 1
            13   11  13 2
            14    8  14 1 #Up