Entry

D00252                      Drug

Name

Carbamazepine (JP18/USP/INN);
Equetro (TN);
Tegretol (TN)

Product

CARNEXIV (Lundbeck Pharmaceuticals LLC), TEGRETOL (Novartis Pharmaceuticals Corporation), TEGRETOL (REMEDYREPACK), CARBATROL (Takeda Pharmaceuticals America), EQUETRO (Validus Pharmaceuticals LLC)

Generic

CARBAMAZEPINE (A-S Medication Solutions), CARBAMAZEPINE (A-S Medication Solutions), CARBAMAZEPINE (A-S Medication Solutions), CARBAMAZEPINE (A-S Medication Solutions), CARBAMAZEPINE (ATLANTIC BIOLOGICALS CORP.), CARBAMAZEPINE (American Health Packaging), CARBAMAZEPINE (American Health Packaging), CARBAMAZEPINE (American Health Packaging), CARBAMAZEPINE (Aphena Pharma Solutions - Tennessee), CARBAMAZEPINE (Aphena Pharma Solutions - Tennessee), CARBAMAZEPINE (Apotex Corp.), CARBAMAZEPINE (Apotex Corp.), CARBAMAZEPINE ER (AustarPharma LLC), CARBAMAZEPINE (AvPAK), CARBAMAZEPINE (Bryant Ranch Prepack), CARBAMAZEPINE (Bryant Ranch Prepack), CARBAMAZEPINE (Bryant Ranch Prepack), CARBAMAZEPINE (Bryant Ranch Prepack), CARBAMAZEPINE (Bryant Ranch Prepack), CARBAMAZEPINE (Bryant Ranch Prepack), CARBAMAZEPINE (Bryant Ranch Prepack), CARBAMAZEPINE (Bryant Ranch Prepack), CARBAMAZEPINE (Bryant Ranch Prepack), CARBAMAZEPINE (Bryant Ranch Prepack), CARBAMAZEPINE (Bryant Ranch Prepack), CARBAMAZEPINE (Bryant Ranch Prepack), CARBAMAZEPINE (Cadila Healthcare Limited), CARBAMAZEPINE (Cardinal Health), CARBAMAZEPINE (Clinical Solutions Wholesale), CARBAMAZEPINE (Eywa Pharma), CARBAMAZEPINE (Golden State Medical Supply), CARBAMAZEPINE (Golden State Medical Supply), CARBAMAZEPINE (Golden State Medical Supply), CARBAMAZEPINE (Jubilant Cadista Pharmaceuticals), CARBAMAZEPINE (Major Pharmaceuticals), CARBAMAZEPINE (Major Pharmaceuticals), CARBAMAZEPINE (Major Pharmaceuticals), CARBAMAZEPINE (Morton Grove Pharmaceuticals), CARBAMAZEPINE (NCS HealthCare of KY), CARBAMAZEPINE (NCS HealthCare of KY), CARBAMAZEPINE (NIVAGEN PHARMACEUTICALS), CARBAMAZEPINE (Northstar Rx LLC), CARBAMAZEPINE (Nostrum Laboratories), CARBAMAZEPINE (NuCare Pharmaceuticals), CARBAMAZEPINE (NuCare Pharmaceuticals), CARBAMAZEPINE (PD-Rx Pharmaceuticals), CARBAMAZEPINE (Pharamaceutical Associates), CARBAMAZEPINE (Pharmaceutical Associates), CARBAMAZEPINE (Prasco Laboratories), CARBAMAZEPINE (Precision Dose), CARBAMAZEPINE (Preferred Pharmaceuticals), CARBAMAZEPINE (Preferred Pharmaceuticals), CARBAMAZEPINE (Proficient Rx LP), CARBAMAZEPINE (REMEDYREPACK), CARBAMAZEPINE (REMEDYREPACK), CARBAMAZEPINE (REMEDYREPACK), CARBAMAZEPINE (REMEDYREPACK), CARBAMAZEPINE (REMEDYREPACK), CARBAMAZEPINE (REMEDYREPACK), CARBAMAZEPINE (REMEDYREPACK), CARBAMAZEPINE (REMEDYREPACK), CARBAMAZEPINE (REMEDYREPACK), CARBAMAZEPINE (REMEDYREPACK), CARBAMAZEPINE (REMEDYREPACK), CARBAMAZEPINE (REMEDYREPACK), CARBAMAZEPINE (REMEDYREPACK), CARBAMAZEPINE (REMEDYREPACK), CARBAMAZEPINE (REMEDYREPACK), CARBAMAZEPINE (REMEDYREPACK), CARBAMAZEPINE (RedPharm Drug), CARBAMAZEPINE (Rising Pharma Holdings), CARBAMAZEPINE (Sandoz), CARBAMAZEPINE (Taro Pharmaceuticals U.S.A.), CARBAMAZEPINE (Taro Pharmaceuticals U.S.A.), EPITOL (Teva Pharmaceuticals USA), CARBAMAZEPINE (Teva Pharmaceuticals USA), CARBAMAZEPINE (Torrent Pharmaceuticals Limited), CARBAMAZEPINE (Upsher-Smith Laboratories), CARBAMAZEPINE (VGYAAN Pharmaceuticals LLC), CARBAMAZEPINE (Zydus Pharmaceuticals (USA)), CARBAMAZEPINE (direct rx)

Formula

C15H12N2O

Exact mass

236.095

Mol weight

236.2686

Structure

Simcomp

Class

Neuropsychiatric agent
DG03199  Antiepileptic agent
  DG02034  Carboxamide antiepileptic
Metabolizing enzyme substrate
DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Metabolizing enzyme inducer
DG02853  CYP3A/CYP3A4 inducer
  DG01635  CYP3A4 inducer
Transporter inducer
DG01893  ABCB1 inducer

Remark

Same as:

C06868

Therapeutic category:

1139 1179

ATC code:

N03AF01

Product:

D00252<JP/US>

Efficacy

Analgesic, Antiepileptic

Disease

Trigeminal neuralgia [DS:H01638]

Comment

Carboxamide derivative

Target

SCN1A [HSA:6323] [KO:K04833]
SCN2A [HSA:6326] [KO:K04834]
SCN3A [HSA:6328] [KO:K04836]
SCN4A [HSA:6329] [KO:K04837]
SCN5A [HSA:6331] [KO:K04838]
SCN8A [HSA:6334] [KO:K04840]
SCN9A [HSA:6335] [KO:K04841]
SCN10A [HSA:6336] [KO:K04842]
SCN11A [HSA:11280] [KO:K04843]

Pathway

hsa04728

Dopaminergic synapse

Metabolism

Enzyme: CYP3A4 [HSA:1576]

Interaction

CYP induction: CYP3A4 [HSA:1576]
Transporter induction: ABCB1 [HSA:5243]

Structure map

map07033

Anticonvulsants

map07231

Sodium channel blocking drugs

Other map

map00982

Drug metabolism - cytochrome P450

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
  N03 ANTIEPILEPTICS
   N03A ANTIEPILEPTICS
    N03AF Carboxamide derivatives
     N03AF01 Carbamazepine
      D00252  Carbamazepine (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Anticonvulsants
  Sodium Channel Agents
   Carbamazepine
    D00252  Carbamazepine (JP18/USP/INN)
Bipolar Agents
  Mood Stabilizers
   Carbamazepine
    D00252  Carbamazepine (JP18/USP/INN)
Central Nervous System Agents
  Central Nervous System, Other
   Carbamazepine
    D00252  Carbamazepine (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   113  Antiepileptics
    1139  Others
     D00252  Carbamazepine (JP18/USP/INN)
   117  Psychotropics
    1179  Others
     D00252  Carbamazepine (JP18/USP/INN)
Drug groups [BR:br08330]
Neuropsychiatric agent
  DG03199  Antiepileptic agent
   DG02034  Carboxamide antiepileptic
    D00252  Carbamazepine
Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D00252  Carbamazepine
Metabolizing enzyme inducer
  DG02853  CYP3A/CYP3A4 inducer
   DG01635  CYP3A4 inducer
    D00252  Carbamazepine
Transporter inducer
  DG01893  ABCB1 inducer
   D00252  Carbamazepine
Drug classes [BR:br08332]
Neuropsychiatric agent
  DG03199  Antiepileptic agent
   D00252  Carbamazepine
Target-based classification of drugs [BR:br08310]
Ion channels
  Voltage-gated ion channels
   Sodium channels
    SCN1A
     D00252  Carbamazepine (JP18/USP/INN) <JP/US>
    SCN2A
     D00252  Carbamazepine (JP18/USP/INN) <JP/US>
    SCN3A
     D00252  Carbamazepine (JP18/USP/INN) <JP/US>
    SCN4A
     D00252  Carbamazepine (JP18/USP/INN) <JP/US>
    SCN5A
     D00252  Carbamazepine (JP18/USP/INN) <JP/US>
    SCN8A
     D00252  Carbamazepine (JP18/USP/INN) <JP/US>
    SCN9A
     D00252  Carbamazepine (JP18/USP/INN) <JP/US>
    SCN10A
     D00252  Carbamazepine (JP18/USP/INN) <JP/US>
    SCN11A
     D00252  Carbamazepine (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
  D00252  Carbamazepine
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
  D00252
Drug transporters
  D00252
Pharmacogenomic biomarkers [br08341.html]
Polymorphisms and mutations affecting drug response
  D00252

Other DBs

CAS:

298-46-4

PubChem:

7847318

ChEBI:

3387

PDB-CCD:

N6W[PDBj]

LigandBox:

D00252

NIKKAJI:

J8.590A

KCF data

ATOM        18
            1   C8y C    25.8138  -16.0918
            2   N1y N    27.0678  -15.4768
            3   C8y C    28.3384  -16.0677
            4   C8y C    28.6645  -17.4200
            5   C8y C    25.5184  -17.4703
            6   C2x C    27.8109  -18.5337
            7   C2x C    26.4089  -18.5521
            8   C8x C    24.7745  -15.1529
            9   C8x C    23.4416  -15.5834
            10  C8x C    23.1462  -16.9619
            11  C8x C    24.1856  -17.9009
            12  C8x C    30.0176  -17.7825
            13  C8x C    31.0080  -16.7920
            14  C8x C    30.6455  -15.4389
            15  C8x C    29.2925  -15.0764
            16  C5a C    27.1234  -14.0772
            17  O5a O    25.8856  -13.3793
            18  N1a N    28.3126  -13.3740
BOND        20
            1     3   4 1
            2     1   5 1
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 2
            8     1   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    5  11 2
            13    4  12 2
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17   15   3 2
            18    2  16 1
            19   16  17 2
            20   16  18 1