Entry

D00275                      Drug

Name

Cisplatin (JP18/USP/INN);
Platinol (TN)

Product

CISPLATIN (WG Critical Care), CISPLATIN (WG Critical Care)

Generic

CISPLATIN (Accord Healthcare), CISPLATIN (Athenex Pharmaceutical Division), CISPLATIN (BluePoint Laboratories), CISPLATIN (Fresenius Kabi USA), CISPLATIN (Gland Pharma Limited), CISPLATIN (Teva Parenteral Medicines), CISPLATIN (West-Ward Pharmaceuticals Corp)

Formula

PtCl2. 2NH3

Exact mass

298.9556

Mol weight

300.051

Structure

Simcomp

Class

Antineoplastic
DG01679 Platinum compound
Transporter substrate
DG02854 SLC22A2 substrate

Remark

Same as:

C06911

Therapeutic category:

4291

ATC code:

L01XA01

Product:

D00275<JP/US>

Efficacy

Antineoplastic, Cell growth inhibitor

Disease

Testicular tumors [DS:H00023]
Ovarian tumors [DS:H00027]
Bladder cancer [DS:H00022]

Comment

platinum compound
DNA alkylator

Target

DNA

Metabolism

Transporter: SLC22A2 [HSA:6582]

Interaction

Structure map

map07040

Antineoplastics - alkylating agents

Other map

map01524

Platinum drug resistance

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01X OTHER ANTINEOPLASTIC AGENTS
    L01XA Platinum compounds
     L01XA01 Cisplatin
      D00275  Cisplatin (JP18/USP/INN) <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
4  Agents affecting cellular function
  42  Antineoplastics
   429  Miscellaneous
    4291  Other Antitumors
     D00275  Cisplatin (JP18/USP/INN)
Drug groups [BR:br08330]
Antineoplastic
  DG01679  Platinum compound
   D00275  Cisplatin
Transporter substrate
  DG02854  SLC22A2 substrate
   D00275  Cisplatin
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
  D00275  Cisplatin
Drug metabolizing enzymes and transporters [br08309.html]
Drug transporters
  D00275
Pharmacogenomic biomarkers [br08341.html]
Polymorphisms and mutations affecting drug response
  D00275

Other DBs

CAS:	15663-27-1

PubChem:

7847341

ChEBI:

27899

PDB-CCD:

CPT[PDBj]

NIKKAJI:

J277.914E

KCF data

ATOM        5
            1   Z   Pt   34.5801  -25.8301
            2   X   Cl   35.9846  -25.8301
            3   X   Cl   34.5743  -27.2286
            4   N0  N    31.9200  -25.8300
            5   N0  N    33.8100  -24.0800
BOND        2
            1     1   2 1
            2     1   3 1