| Entry |
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|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Name | Clarithromycin (JP18/USP/INN); Biaxin (TN) | ||||||||||||
| Product | |||||||||||||
| Generic | CLARITHROMYCIN (A-S Medication Solutions), CLARITHROMYCIN (A-S Medication Solutions), CLARITHROMYCIN (A-S Medication Solutions), CLARITHROMYCIN (A-S Medication Solutions), CLARITHROMYCIN (A-S Medication Solutions), CLARITHROMYCIN (A-S Medication Solutions), CLARITHROMYCIN (Actavis Pharma), CLARITHROMYCIN (Ajanta Pharma USA), CLARITHROMYCIN (Alembic Pharmaceuticals), CLARITHROMYCIN (American Health Packaging), CLARITHROMYCIN (Asclemed USA), CLARITHROMYCIN (Aurobindo Pharma Limited), CLARITHROMYCIN (AvPAK), CLARITHROMYCIN (Bryant Ranch Prepack), CLARITHROMYCIN (Bryant Ranch Prepack), CLARITHROMYCIN (Bryant Ranch Prepack), CLARITHROMYCIN (Bryant Ranch Prepack), CLARITHROMYCIN (Bryant Ranch Prepack), CLARITHROMYCIN (Bryant Ranch Prepack), CLARITHROMYCIN (Bryant Ranch Prepack), CLARITHROMYCIN (Chartwell RX), CLARITHROMYCIN (Denton Pharma), CLARITHROMYCIN (Denton Pharma), CLARITHROMYCIN (Denton Pharma), CLARITHROMYCIN (DirectRX), CLARITHROMYCIN (DirectRx), CLARITHROMYCIN (Direct_Rx), CLARITHROMYCIN (Lannett Company), CLARITHROMYCIN (Lannett Company), CLARITHROMYCIN (Major Pharmaceuticals), CLARITHROMYCIN (NuCare Pharmaceuticals), CLARITHROMYCIN (NuCare Pharmaceuticals), CLARITHROMYCIN (PD-Rx Pharmaceuticals), CLARITHROMYCIN (PD-Rx Pharmaceuticals), CLARITHROMYCIN (PD-Rx Pharmaceuticals), CLARITHROMYCIN (PD-Rx Pharmaceuticals), CLARITHROMYCIN (Preferred Pharmaceuticals), CLARITHROMYCIN (Preferred Pharmaceuticals), CLARITHROMYCIN (Proficient Rx LP), CLARITHROMYCIN (Proficient Rx LP), CLARITHROMYCIN (REMEDYREPACK), CLARITHROMYCIN (RPK Pharmaceuticals), CLARITHROMYCIN (RPK Pharmaceuticals), CLARITHROMYCIN (RedPharm Drug), CLARITHROMYCIN (RedPharm Drug), CLARITHROMYCIN (RedPharm Drug), CLARITHROMYCIN (RedPharm Drug), CLARITHROMYCIN (Rising Health), CLARITHROMYCIN (Sandoz), CLARITHROMYCIN (Sandoz), CLARITHROMYCIN (Strides Pharma Science Limited) | ||||||||||||
| Formula | C38H69NO13 | ||||||||||||
| Exact mass | 747.4769 | ||||||||||||
| Mol weight | 747.9534 | ||||||||||||
| Structure |  | ||||||||||||
| Simcomp | |||||||||||||
| Class | Antibacterial DG01551 Macrolide antibiotic DG01874 14-membered ring macrolide antibiotic Metabolizing enzyme substrate DG01633 CYP3A/CYP3A4 substrate DG02913 CYP3A4 substrate Metabolizing enzyme inhibitor DG02852 CYP3A/CYP3A4 inhibitor DG01522 CYP3A4 inhibitor Transporter inhibitor DG01622 ABCB1 inhibitor | ||||||||||||
| Remark |
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| Efficacy | Antibacterial, Protein biosynthesis inhibitor | ||||||||||||
| Disease | Pharyngitis/tonsillitis [DS:H01424] Helicobacter pylori infection [DS:H00320] | ||||||||||||
| Target | 50S ribosomal subunit | ||||||||||||
| Pathway |
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| Metabolism | Enzyme: CYP3A4 [HSA:1576] | ||||||||||||
| Interaction | CYP inhibition: CYP3A4 [HSA:1576] Transporter inhibition: ABCB1 [HSA:5243] | ||||||||||||
| Structure map |
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| Brite | Anatomical Therapeutic Chemical (ATC) classification [BR:br08303] J ANTIINFECTIVES FOR SYSTEMIC USE J01 ANTIBACTERIALS FOR SYSTEMIC USE J01F MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS J01FA Macrolides J01FA09 Clarithromycin D00276 Clarithromycin (JP18/USP/INN) <JP/US> USP drug classification [BR:br08302] Antibacterials Macrolides Clarithromycin D00276 Clarithromycin (JP18/USP/INN) Therapeutic category of drugs in Japan [BR:br08301] 6 Agents against pathologic organisms and parasites 61 Antibiotics 614 Acting mainly on gram-positive bacteria and mycoplasma 6149 Others D00276 Clarithromycin (JP18/USP/INN) Drug groups [BR:br08330] Antibacterial DG01551 Macrolide antibiotic DG01874 14-membered ring macrolide antibiotic DG00605 Clarithromycin D00276 Clarithromycin Metabolizing enzyme substrate DG01633 CYP3A/CYP3A4 substrate DG02913 CYP3A4 substrate DG00605 Clarithromycin D00276 Clarithromycin Metabolizing enzyme inhibitor DG02852 CYP3A/CYP3A4 inhibitor DG01522 CYP3A4 inhibitor DG00605 Clarithromycin D00276 Clarithromycin Transporter inhibitor DG01622 ABCB1 inhibitor DG00605 Clarithromycin D00276 Clarithromycin Drug classes [BR:br08332] Antibacterial DG01551 Macrolide antibiotic D00276 Clarithromycin Antimicrobials [BR:br08307] Antibacterials Protein biosynthesis inhibitor Macrolide D00276 Clarithromycin (JP18/USP/INN) <JP/US> Drugs listed in the Japanese Pharmacopoeia [BR:br08311] Chemicals D00276 Clarithromycin D00276 Clarithromycin tablets D00276 Clarithromycin for syrup Drug metabolizing enzymes and transporters [br08309.html] Drug metabolizing enzymes D00276 Drug transporters D00276 Drug groups [BR:br08330] Antibacterial DG01551 Macrolide antibiotic DG01874 14-membered ring macrolide antibiotic DG00605 Clarithromycin Metabolizing enzyme substrate DG01633 CYP3A/CYP3A4 substrate DG02913 CYP3A4 substrate DG00605 Clarithromycin Metabolizing enzyme inhibitor DG02852 CYP3A/CYP3A4 inhibitor DG01522 CYP3A4 inhibitor DG00605 Clarithromycin Transporter inhibitor DG01622 ABCB1 inhibitor DG00605 Clarithromycin Antimicrobials abbreviations [BR:br08327] Antibacterials Protein biosynthesis inhibitor Macrolide DG00605 Clarithromycin | ||||||||||||
| Other DBs |
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| KCF data | ATOM 52 1 C1y C 24.1709 -17.2043 2 C1z C 24.1709 -15.8400 3 C1y C 22.9859 -17.8807 4 O2a O 25.6666 -18.4812 5 C1x C 22.9859 -15.1580 6 C1y C 22.9859 -19.2450 7 C1a C 21.9450 -16.9275 8 C1y C 27.4458 -17.6943 9 C1y C 22.9859 -13.7880 10 O2a O 23.7258 -20.6034 11 C1y C 21.8123 -19.9272 12 C1y C 28.5906 -18.4120 13 O2x O 27.4113 -16.3303 14 C5x C 21.8123 -13.1116 15 C1a C 24.1709 -13.1116 16 C1y C 24.7548 -21.7190 17 C7x C 20.6273 -19.2450 18 C1a C 21.8123 -21.2912 19 C1y C 29.7920 -17.7775 20 O1a O 28.5500 -19.7801 21 C1y C 28.6878 -15.6932 22 C1y C 20.6273 -13.7880 23 O5x O 21.8123 -11.7473 24 C1x C 24.7548 -23.0776 25 O2x O 25.9398 -21.0369 26 O7x O 20.6273 -17.8807 27 O6a O 19.5695 -20.1930 28 C1x C 29.8379 -16.4196 29 C1a C 28.7389 -14.3326 30 C1y C 20.6273 -15.1580 31 C1a C 19.4481 -13.1116 32 C1z C 25.9398 -23.7654 33 C1y C 27.1133 -21.7190 34 C1y C 19.4481 -17.2043 35 C1z C 19.4481 -15.8400 36 O1a O 21.8123 -15.8400 37 C1y C 27.1133 -23.0776 38 O2a O 25.9398 -25.0892 39 C1a C 28.2983 -21.0428 40 C1b C 18.2688 -17.8807 41 C1a C 18.1995 -16.4066 42 O1a O 18.1995 -15.1522 43 O1a O 28.2983 -23.7654 44 C1a C 18.3035 -19.0021 45 C1a C 25.3593 -16.5254 46 C1a C 27.1615 -25.7951 47 C1a C 24.7273 -24.4654 48 O2a O 24.8709 -14.6276 49 C1a C 26.2709 -14.6276 50 N1c N 30.9997 -18.5339 51 C1a C 32.2377 -17.8772 52 C1a C 31.0187 -19.9487 BOND 54 1 1 2 1 2 1 3 1 3 1 4 1 #Down 4 2 5 1 5 3 6 1 6 3 7 1 #Down 7 8 4 1 #Down 8 5 9 1 9 6 10 1 #Down 10 6 11 1 11 8 12 1 12 8 13 1 13 9 14 1 14 9 15 1 #Down 15 16 10 1 #Down 16 11 17 1 17 11 18 1 #Up 18 12 19 1 19 12 20 1 #Up 20 13 21 1 21 14 22 1 22 14 23 2 23 16 24 1 24 16 25 1 25 17 26 1 26 17 27 2 27 19 28 1 28 21 29 1 #Down 29 22 30 1 30 22 31 1 #Up 31 24 32 1 32 25 33 1 33 26 34 1 34 30 35 1 35 30 36 1 #Up 36 32 37 1 37 32 38 1 #Down 38 33 39 1 #Up 39 34 40 1 #Down 40 35 41 1 #Down 41 35 42 1 #Up 42 37 43 1 #Down 43 40 44 1 44 21 28 1 45 33 37 1 46 34 35 1 47 2 45 1 #Down 48 38 46 1 49 32 47 1 50 2 48 1 #Up 51 48 49 1 52 19 50 1 #Down 53 50 51 1 54 50 52 1 |