Entry

D00280                      Drug

Name

Clonazepam (JP18/USP/INN);
Klonopin (TN)

Product

KLONOPIN (Genentech), KLONOPIN (H2-Pharma)

Generic

CLONAZEPAM (A-S Medication Solutions), CLONAZEPAM (A-S Medication Solutions), CLONAZEPAM (A-S Medication Solutions), CLONAZEPAM (A-S Medication Solutions), CLONAZEPAM (A-S Medication Solutions), CLONAZEPAM (ATLANTIC BIOLOGICALS CORP.), CLONAZEPAM (Accord Healthcare), CLONAZEPAM (Advanced Rx Pharmacy of Tennessee), CLONAZEPAM (Advanced Rx Pharmacy of Tennessee), CLONAZEPAM (Alembic Pharmaceuticals), CLONAZEPAM (Alembic Pharmaceuticals Limited), CLONAZEPAM (American Health Packaging), CLONAZEPAM (Aphena Pharma Solutions - Tennessee), CLONAZEPAM (Aphena Pharma Solutions - Tennessee), CLONAZEPAM (Aphena Pharma Solutions - Tennessee), CLONAZEPAM (Aphena Pharma Solutions - Tennessee), CLONAZEPAM (Aphena Pharma Solutions - Tennessee), CLONAZEPAM (Aphena Pharma Solutions - Tennessee), CLONAZEPAM (Aphena Pharma Solutions - Tennessee), CLONAZEPAM (Aphena Pharma Solutions - Tennessee), CLONAZEPAM (Aphena Pharma Solutions - Tennessee), CLONAZEPAM (Aphena Pharma Solutions - Tennessee), CLONAZEPAM (Aphena Pharma Solutions - Tennessee), CLONAZEPAM (Bryant Ranch Prepack), CLONAZEPAM (Bryant Ranch Prepack), CLONAZEPAM (Bryant Ranch Prepack), CLONAZEPAM (Bryant Ranch Prepack), CLONAZEPAM (Bryant Ranch Prepack), CLONAZEPAM (Bryant Ranch Prepack), CLONAZEPAM (Bryant Ranch Prepack), CLONAZEPAM (Bryant Ranch Prepack), CLONAZEPAM (Bryant Ranch Prepack), CLONAZEPAM (Bryant Ranch Prepack), CLONAZEPAM (Bryant Ranch Prepack), CLONAZEPAM (Bryant Ranch Prepack), CLONAZEPAM (Bryant Ranch Prepack), CLONAZEPAM (Bryant Ranch Prepack), CLONAZEPAM (Bryant Ranch Prepack), CLONAZEPAM (Bryant Ranch Prepack), CLONAZEPAM (Bryant Ranch Prepack), CLONAZEPAM (Cardinal Health), CLONAZEPAM (Clinical Solutions Wholesale), CLONAZEPAM (DIRECT RX), CLONAZEPAM (DIRECT RX), CLONAZEPAM (DIRECT RX), CLONAZEPAM (Direct_Rx), CLONAZEPAM (Direct_Rx), CLONAZEPAM (Golden State Medical Supply), CLONAZEPAM (Golden State Medical Supply), CLONAZEPAM (Lake Erie Medical DBA Quality Care Products LLC), CLONAZEPAM (Major Pharmaceuticals), CLONAZEPAM (Medsource Pharmaceuticals), CLONAZEPAM (NCS HealthCare of KY), CLONAZEPAM (NuCare Pharmaceuticals), CLONAZEPAM (NuCare Pharmaceuticals), CLONAZEPAM (NuCare Pharmaceuticals), CLONAZEPAM (NuCare Pharmaceuticals), CLONAZEPAM (NuCare Pharmaceuticals), CLONAZEPAM (PD-Rx Pharmaceuticals), CLONAZEPAM (PD-Rx Pharmaceuticals), CLONAZEPAM (PD-Rx Pharmaceuticals), CLONAZEPAM (Preferred Pharmaceuticals), CLONAZEPAM (Preferred Pharmaceuticals), CLONAZEPAM (Preferred Pharmaceuticals), CLONAZEPAM (Proficient Rx LP), CLONAZEPAM (Proficient Rx LP), CLONAZEPAM (Proficient Rx LP), CLONAZEPAM (Proficient Rx LP), CLONAZEPAM (Proficient Rx LP), CLONAZEPAM (Quality Care Products), CLONAZEPAM (REMEDYREPACK), CLONAZEPAM (REMEDYREPACK), CLONAZEPAM (REMEDYREPACK), CLONAZEPAM (REMEDYREPACK), CLONAZEPAM (REMEDYREPACK), CLONAZEPAM (REMEDYREPACK), CLONAZEPAM (REMEDYREPACK), CLONAZEPAM (REMEDYREPACK), CLONAZEPAM (REMEDYREPACK), CLONAZEPAM (REMEDYREPACK), CLONAZEPAM (REMEDYREPACK), CLONAZEPAM (REMEDYREPACK), CLONAZEPAM (REMEDYREPACK), CLONAZEPAM (RPK Pharmaceuticals), CLONAZEPAM (Solco Healthcare LLC), CLONAZEPAM (St Marys Medical Park Pharmacy), CLONAZEPAM (Sun Pharmaceutical Industries), CLONAZEPAM (Teva Pharmaceuticals USA), CLONAZEPAM (Teva Pharmaceuticals USA)

Formula

C15H10ClN3O3

Exact mass

315.0411

Mol weight

315.7112

Structure

Simcomp

Class

Neuropsychiatric agent
DG01567  GABA-A receptor agonist
DG03199  Antiepileptic agent
  DG02036  Benzodiazepine derivative, antiepileptic

Remark

Therapeutic category:

1139

ATC code:

N03AE01

Product:

D00280<JP/US>

Efficacy

Anticonvulsant, Antiepileptic

Disease

Lennox-Gastaut syndrome [DS:H01813]
Panic disorder [DS:H01664]

Comment

Benzodiazepine derivative
Cytochrome P-450 including CYP3A, may play an important role in clonazepam reduction and oxidation.

Target

GABR [HSA:2554 2555 2556 2557 2558 2559 2560 2561 2562 2563 2564 2565 2566 2567 2568 55879] [KO:K05175 K05181 K05184 K05185 K05186 K05189 K05192]

Pathway

hsa04080

Neuroactive ligand-receptor interaction

hsa04727

GABAergic synapse

Interaction

Structure map

map07033

Anticonvulsants

map07230

GABA-A receptor agonists/antagonists

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
  N03 ANTIEPILEPTICS
   N03A ANTIEPILEPTICS
    N03AE Benzodiazepine derivatives
     N03AE01 Clonazepam
      D00280  Clonazepam (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Anticonvulsants
  Gamma-aminobutyric Acid (GABA) Augmenting Agents
   Benzodiazepines
    Clonazepam
     D00280  Clonazepam (JP18/USP/INN)
Anxiolytics
  Benzodiazepines
   Clonazepam
    D00280  Clonazepam (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   113  Antiepileptics
    1139  Others
     D00280  Clonazepam (JP18/USP/INN)
Drug groups [BR:br08330]
Neuropsychiatric agent
  DG01567  GABA-A receptor agonist
   D00280  Clonazepam
  DG03199  Antiepileptic agent
   DG02036  Benzodiazepine derivative, antiepileptic
    D00280  Clonazepam
Drug classes [BR:br08332]
Neuropsychiatric agent
  DG03199  Antiepileptic agent
   D00280  Clonazepam
Target-based classification of drugs [BR:br08310]
Ion channels
  Ligand-gated ion channels
   GABA (ionotropic)
    GABR
     D00280  Clonazepam (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
  D00280  Clonazepam
  D00280  Clonazepam tablets
  D00280  Clonazepam fine granules

Other DBs

CAS:

1622-61-3

PubChem:

7847346

ChEBI:

3756

LigandBox:

D00280

NIKKAJI:

J5.233G

KCF data

ATOM        22
            1   C2y C    18.3334  -14.2894
            2   C8y C    17.4913  -13.1798
            3   C8y C    17.8265  -11.8230
            4   N1x N    19.0875  -11.2449
            5   N2x N    19.7392  -14.3146
            6   C5x C    20.3411  -11.8672
            7   C1x C    20.6276  -13.2359
            8   C8x C    16.8194  -10.8546
            9   C8x C    15.4774  -11.2427
            10  C8y C    15.1422  -12.5995
            11  C8x C    16.1493  -13.5676
            12  N2b N    13.7774  -12.9939 #+
            13  C8y C    17.6989  -15.5391
            14  C8x C    16.2973  -15.5391
            15  O5x O    21.4503  -11.0095
            16  C8x C    15.5973  -16.7516
            17  C8x C    16.2973  -17.9640
            18  C8x C    17.6989  -17.9640
            19  C8y C    18.3989  -16.7516
            20  X   Cl   19.8098  -16.7517
            21  O3a O    12.6477  -11.9025 #-
            22  O3a O    13.4361  -14.3745
BOND        24
            1     3   4 1
            2     1   5 2
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    2  11 2
            13   10  12 1
            14    1  13 1
            15   13  14 1
            16    6  15 2
            17   14  16 2
            18   16  17 1
            19   17  18 2
            20   18  19 1
            21   13  19 2
            22   19  20 1
            23   12  21 1
            24   12  22 2