Demeclocycline hydrochloride


Entry
D00290                      Drug                                   
Name
Demeclocycline hydrochloride (USP);
Demethylchlortetracycline hydrochloride (JP18);
Declomycin (TN)
Product
  Generic
DEMECLOCYCLINE HYDROCHLORIDE (American Health Packaging), DEMECLOCYCLINE HYDROCHLORIDE (Amneal Pharmaceuticals LLC), DEMECLOCYCLINE HYDROCHLORIDE (Amneal Pharmaceuticals of New York LLC), DEMECLOCYCLINE HYDROCHLORIDE (American Health Packaging), DEMECLOCYCLINE HYDROCHLORIDE (Epic Pharma), DEMECLOCYCLINE HYDROCHLORIDE (Golden State Medical Supply), DEMECLOCYCLINE HYDROCHLORIDE (Golden State Medical Supply), DEMECLOCYCLINE HYDROCHLORIDE (PuraCap Laboratories LLC)
Formula
C21H21ClN2O8. HCl
Exact mass
500.0753
Mol weight
501.314
Structure
Simcomp
Class
Antibacterial
 DG01197  Tetracycline antibiotic
Remark
Therapeutic category: 6152
ATC code: D06AA01 J01AA01
Chemical structure group: DG00396
Product (DG00396): D00290<JP/US>
Efficacy
Antibacterial, Protein biosynthesis inhibitor
  Disease
Rocky Mountain spotted fever [DS:H00323]
Typhus fever [DS:H00322]
Q fever [DS:H00310]
Lymphogranuloma venereum [DS:H00348]
Psittacosis [DS:H00350]
Trachoma [DS:H00349]
Relapsing fever [DS:H00427]
Chancroid [DS:H00305]
Plague [DS:H00297]
Tularemia [DS:H00312]
Cholera [DS:H00110]
Campylobacter fetus infections [DS:H00321]
Brucellosis [DS:H00325]
Bartonellosis [DS:H00326]
Granuloma inguinale [DS:H01415]
Syphilis [DS:H00354]
Yaws [DS:H01318]
Listeriosis [DS:H00332]
Anthrax [DS:H00328]
Vincent's infection [DS:H01440]
Actinomycosis [DS:H01325]
Target
30S ribosomal subunit
  Pathway
ko03010  Ribosome
Interaction
Structure map
map07019  Tetracyclines
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D06 ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE
   D06A ANTIBIOTICS FOR TOPICAL USE
    D06AA Tetracycline and derivatives
     D06AA01 Demeclocycline
      D00290  Demeclocycline hydrochloride (USP) <JP/US>
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01A TETRACYCLINES
    J01AA Tetracyclines
     J01AA01 Demeclocycline
      D00290  Demeclocycline hydrochloride (USP) <JP/US>
USP drug classification [BR:br08302]
 Antibacterials
  Tetracyclines
   Demeclocycline
    D00290  Demeclocycline hydrochloride (USP)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  61  Antibiotics
   615  Acting mainly on gram-positive bacteria, gram-negative bacteria, rickettsia and chlamydia
    6152  Tetracycline antibiotics
     D00290  Demeclocycline hydrochloride (USP); Demethylchlortetracycline hydrochloride (JP18)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for integumentary system
  56 Purulent skin remedies
   D00290  Demeclocycline hydrochloride (USP)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Demethylchlortetracycline
    D00290  Demeclocycline hydrochloride (USP)
Drug groups [BR:br08330]
 Antibacterial
  DG01197  Tetracycline antibiotic
   DG00396  Demeclocycline
    D00290  Demeclocycline hydrochloride
Drug classes [BR:br08332]
 Antibacterial
  DG01197  Tetracycline antibiotic
   D00290  Demeclocycline hydrochloride
Antimicrobials [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   Tetracycline
    D00290  Demeclocycline hydrochloride (USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00290  Demethylchlortetracycline hydrochloride
Drug groups [BR:br08330]
 Antibacterial
  DG01197  Tetracycline antibiotic
   DG00396  Demeclocycline
Antimicrobials abbreviations [BR:br08327]
 Antibacterials
  Protein biosynthesis inhibitor
   Tetracycline
    DG00396  Demeclocycline
Other DBs
CAS: 64-73-3
PubChem: 7847356
ChEBI: 4392 59725
LigandBox: D00290
NIKKAJI: J231.287E
KCF data

ATOM        33
            1   C1y C    27.8011  -14.6050
            2   C1z C    27.7894  -15.9888
            3   C1y C    29.0038  -13.9160
            4   C1x C    26.5925  -13.9044
            5   C2y C    26.5925  -16.6895
            6   C5x C    28.9863  -16.6895
            7   O1a O    27.7894  -17.3842
            8   C2y C    30.2007  -14.6167
            9   N1c N    29.0097  -12.5149
            10  C1y C    25.3840  -14.6050
            11  C2y C    25.3840  -16.0005
            12  O1a O    26.5984  -18.0964
            13  C2y C    30.1949  -16.0063
            14  O5x O    28.9806  -18.0905
            15  O1a O    31.4151  -13.9220
            16  C1a C    30.2300  -11.8202
            17  C1a C    27.8011  -11.8085
            18  C1y C    24.1697  -13.9044
            19  C5x C    24.1814  -16.7069
            20  C5a C    31.3975  -16.7069
            21  C8y C    22.9611  -14.6167
            22  O1a O    24.1697  -12.5032
            23  C8y C    22.9669  -16.0122
            24  O5x O    24.1231  -18.1081
            25  N1a N    32.6177  -16.0180
            26  O5a O    31.4617  -18.1138
            27  C8y C    21.7467  -13.9160
            28  C8y C    21.7643  -16.7186
            29  C8x C    20.5323  -14.6284
            30  X   Cl   21.7409  -12.5091
            31  C8x C    20.5440  -16.0296
            32  O1a O    21.7760  -18.1255
            33  X   Cl   35.9659  -14.7457
BOND        35
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     2   7 1 #Down
            7     3   8 1
            8     3   9 1 #Down
            9     4  10 1
            10    5  11 2
            11    5  12 1
            12    6  13 1
            13    6  14 2
            14    8  15 1
            15    9  16 1
            16    9  17 1
            17   10  18 1
            18   11  19 1
            19   13  20 1
            20   18  21 1
            21   18  22 1 #Up
            22   19  23 1
            23   19  24 2
            24   20  25 1
            25   20  26 2
            26   21  27 1
            27   23  28 1
            28   27  29 2
            29   27  30 1
            30   28  31 2
            31   28  32 1
            32    8  13 2
            33   10  11 1
            34   21  23 2
            35   29  31 1