Entry

D00292                      Drug

Name

Dexamethasone (JP18/USP/INN);
Decadron (TN);
Maxidex (TN)

Product

HEMADY (Acrotech Biopharma LLC), MAXIDEX (Alcon Laboratories), OZURDEX (Allergan), DEXYCU (EyePoint Pharmaceuticals US), MAXIDEX (Novartis Pharmaceuticals Corporation), DEXTENZA (Ocular Therapeutix)

Generic

DEXAMETHASONE (A-S Medication Solutions), DEXAMETHASONE (A-S Medication Solutions), DEXAMETHASONE (A-S Medication Solutions), DEXAMETHASONE (A-S Medication Solutions), DEXAMETHASONE (Alvogen), DEXAMETHASONE (Amneal Pharmaceuticals NY LLC), DEXAMETHASONE (AvKARE), DEXAMETHASONE (Bryant Ranch Prepack), DEXAMETHASONE (Bryant Ranch Prepack), DEXAMETHASONE (Bryant Ranch Prepack), DEXAMETHASONE (Bryant Ranch Prepack), DEXAMETHASONE (Cardinal Health), DEXAMETHASONE (Direct Rx), DEXAMETHASONE (Direct Rx), DEXAMETHASONE (Doc Rx), DEXAMETHASONE (Fera Pharmaceuticals), DEXAMETHASONE (Fera Pharmaceuticals), DEXAMETHASONE (Golden State Medical Supply), DEXAMETHASONE (Lake Erie Medical DBA Quality Care Products LLC), DEXAMETHASONE (Morton Grove Pharmaceuticals), DEXAMETHASONE (Novitium Pharma LLC), DEXAMETHASONE (NuCare Pharmaceuticals), DEXAMETHASONE (NuCare Pharmaceuticals), DEXAMETHASONE (NuCare Pharmaceuticals), DEXAMETHASONE (PD-Rx Pharmaceuticals), DEXAMETHASONE (PD-Rx Pharmaceuticals), DEXAMETHASONE (PD-Rx Pharmaceuticals), DEXAMETHASONE (Pharmaceutical Associates), DEXAMETHASONE (Prasco Laboratories), DEXAMETHASONE (Preferred Pharmaceuticals), DEXAMETHASONE (Preferred Pharmaceuticals), DEXAMETHASONE (Proficient Rx LP), DEXAMETHASONE (Proficient Rx LP), TAPERDEX 6-DAY (Proficient Rx LP), TAPERDEX 12-DAY (Proficient Rx LP), TAPERDEX 6-DAY (Quality Care Products), DEXAMETHASONE (Quality Care Products), DEXAMETHASONE (REMEDYREPACK), DEXAMETHASONE (REMEDYREPACK), DEXAMETHASONE (RedPharm Drug), DEXAMETHASONE (RedPharm Drug), DEXAMETHASONE (Rising Pharmaceuticals), DEXAMETHASONE (STI Pharma LLC), ZCORT (Scite Pharma), DEXAMETHASONE (Xspire Pharma), TAPERDEX 6-DAY (Xspire Pharma), TAPERDEX 7-DAY (Xspire Pharma), TAPERDEX 12-DAY (Xspire Pharma), DEXAMETHASONE 6-DAY (Xspire Pharma), DEXAMETHASONE (medsource pharmaceuticals), DEXAMETHASONE (Larken Laboratories), DEXAMETHASONE (Larken Laboratories), DEXAMETHASONE INTENSOL (West-Ward Pharmaceuticals Corp.)

Formula

C22H29FO5

Exact mass

392.1999

Mol weight

392.4611

Structure

Simcomp

Class

Anti-inflammatory
DG01955  Corticosteroid
  DG02068  Glucocorticoid
Metabolizing enzyme substrate
DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Metabolizing enzyme inducer
DG02853  CYP3A/CYP3A4 inducer
  DG01635  CYP3A4 inducer

Remark

Same as:

C15643

Therapeutic category:

1315 2399 2454 2646

ATC code:

A01AC02 C05AA09 D07AB19 D07XB05 D10AA03 H02AB02 R01AD03 S01BA01 S01CB01 S02BA06 S03BA01

Chemical structure group:

DG00011

Product (DG00011):

D00292<JP/US> D00975<JP/US> D01510<JP> D01615<JP> D01632<JP> D01948<JP> D07073<JP>

Product (mixture):

D08733<JP> D10296<US> D11177<US> D11178<US>

Efficacy

Anti-inflammatory, Antipruritic, Glucocorticoid receptor agonist

Disease

Diabetic macular edema [DS:H01651]
Asthma [DS:H00079]
Atopic dermatitis [DS:H01358]
Contact dermatitis [DS:H01357]
Allergic rhinitis [DS:H01360]
Bullous dermatitis herpetiformis [DS:H01362]
Mycosis fungoides [DS:H01463]
Pemphigus [DS:H01648]
Erythema multiforme [DS:H01695]
Stevens-Johnson syndrome [DS:H01694]
Congenital adrenal hyperplasia [DS:H00216]
Ulcerative colitis [DS:H01466]
Acquired (autoimmune) hemolytic anemia [DS:H01585]
Congenital (erythroid) hypoplastic anemia; Diamond-Blackfan anemia [DS:H00237]
Pure red cell aplasia [DS:H01586]
Multiple sclerosis [DS:H01490]
Temporal arteritis [DS:H01698]
Nephrotic syndrome [DS:H01657]
Pulmonary tuberculosis [DS:H00342]
Acute gouty arthritis [DS:H01532]
Ankylosing spondylitis [DS:H01674]
Psoriatic arthritis [DS:H01507]
Rheumatoid arthritis [DS:H00630]
Juvenile rheumatoid arthritis [DS:H01672]
Dermatomyositis and polymyositis [DS:H01604]
Systemic lupus erythematosus [DS:H00080]

Target

NR3C1 (GR) [HSA:2908] [KO:K05771]

Pathway

hsa04080

Neuroactive ligand-receptor interaction

Metabolism

Enzyme: CYP3A4 [HSA:1576]

Interaction

CYP induction: CYP3A4 [HSA:1576]

Structure map

map07043

Antineoplastics - hormones

map07046

Immunosuppressive agents

map07225

Glucocorticoid and mineralocorticoid receptor agonists/antagonists

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AC Corticosteroids for local oral treatment
     A01AC02 Dexamethasone
      D00292  Dexamethasone (JP18/USP/INN) <JP/US>
C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA09 Dexamethasone
      D00292  Dexamethasone (JP18/USP/INN) <JP/US>
D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AB Corticosteroids, moderately potent (group II)
     D07AB19 Dexamethasone
      D00292  Dexamethasone (JP18/USP/INN) <JP/US>
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XB Corticosteroids, moderately potent, other combinations
     D07XB05 Dexamethasone
      D00292  Dexamethasone (JP18/USP/INN) <JP/US>
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AA Corticosteroids, combinations for treatment of acne
     D10AA03 Dexamethasone
      D00292  Dexamethasone (JP18/USP/INN) <JP/US>
H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB02 Dexamethasone
      D00292  Dexamethasone (JP18/USP/INN) <JP/US>
R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AD Corticosteroids
     R01AD03 Dexamethasone
      D00292  Dexamethasone (JP18/USP/INN) <JP/US>
S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA01 Dexamethasone
      D00292  Dexamethasone (JP18/USP/INN) <JP/US>
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB01 Dexamethasone
      D00292  Dexamethasone (JP18/USP/INN) <JP/US>
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA06 Dexamethasone
      D00292  Dexamethasone (JP18/USP/INN) <JP/US>
  S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
   S03B CORTICOSTEROIDS
    S03BA Corticosteroids
     S03BA01 Dexamethasone
      D00292  Dexamethasone (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
  Dexamethasone
   D00292  Dexamethasone (JP18/USP/INN)
Inflammatory Bowel Disease Agents
  Glucocorticoids
   Dexamethasone
    D00292  Dexamethasone (JP18/USP/INN)
Ophthalmic Agents
  Ophthalmic Anti-inflammatories
   Glucocorticoids, Ophthalmic
    Dexamethasone
     D00292  Dexamethasone (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1315  Ophthalmic cortisones
     D00292  Dexamethasone (JP18/USP/INN)
2  Agents affecting individual organs
  23  Digestive organ agents
   239  Miscellaneous
    2399  Others
     D00292  Dexamethasone (JP18/USP/INN)
  24  Hormones
   245  Adrenal hormone preparations
    2454  Fluorinated adrenocorticotropic hormones
     D00292  Dexamethasone (JP18/USP/INN)
  26  Epidermides
   264  Analgesics, anti-itchings, astringents, anti-inflammatory agents
    2646  Adrenocorticotropic hormones
     D00292  Dexamethasone (JP18/USP/INN)
Classification of Japanese OTC drugs [BR:br08313]
Agents for integumentary system
  57 Analgesic, antipruritic, astringent, and anti-inflammatory remedies (incl. gel patches)
   D00292  Dexamethasone (JP18/USP/INN)
Risk category of Japanese OTC drugs [BR:br08312]
Designated second-class OTC drugs
  Inorganic and organic chemicals
   Dexamethasone
    D00292  Dexamethasone (JP18/USP/INN)
Second-class OTC drugs
  Inorganic and organic chemicals
   Dexamethasone
    D00292  Dexamethasone (JP18/USP/INN)
Drug groups [BR:br08330]
Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG00011  Dexamethasone
     D00292  Dexamethasone
Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00011  Dexamethasone
     D00292  Dexamethasone
Metabolizing enzyme inducer
  DG02853  CYP3A/CYP3A4 inducer
   DG01635  CYP3A4 inducer
    DG00011  Dexamethasone
     D00292  Dexamethasone
Drug classes [BR:br08332]
Anti-inflammatory
  DG01955  Corticosteroid
   D00292  Dexamethasone
Target-based classification of drugs [BR:br08310]
Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D00292  Dexamethasone (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
  D00292  Dexamethasone
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
  D00292
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
  D00292
Topical steroids potency [br08317.html]
Classification in Japan
  D00292
Drug groups [BR:br08330]
Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG00011  Dexamethasone
Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00011  Dexamethasone
Metabolizing enzyme inducer
  DG02853  CYP3A/CYP3A4 inducer
   DG01635  CYP3A4 inducer
    DG00011  Dexamethasone

Other DBs

CAS:

50-02-2

PubChem:

7847358

ChEBI:

41879

PDB-CCD:

DEX[PDBj]

LigandBox:

D00292

NIKKAJI:

J1.356K

KCF data

ATOM        28
            1   C2x C     6.5292  -16.7310
            2   C5x C     6.5292  -18.0917
            3   C2x C     7.7075  -18.7720
            4   C2y C     8.8859  -18.0917
            5   C1z C     8.8859  -16.7310
            6   C2x C     7.7075  -16.0507
            7   C1x C    10.0643  -18.7720
            8   C1x C    11.2426  -18.0917
            9   C1y C    11.2426  -16.7310
            10  C1z C    10.0643  -16.0507
            11  C1y C    12.4210  -16.0507
            12  C1z C    12.4210  -14.6900
            13  C1x C    11.2426  -14.0097
            14  C1y C    10.0643  -14.6900
            15  C1x C    14.7777  -16.0507
            16  C1y C    14.7777  -14.6900
            17  C1z C    13.5994  -14.0097
            18  C1a C     8.8859  -15.3703
            19  O1a O     8.8879  -14.0109
            20  C1a C    12.4210  -13.3294
            21  C1a C    15.9436  -14.0168
            22  C5a C    13.5994  -12.3089
            23  X   F    10.0643  -17.4113
            24  O1a O    14.7777  -13.1194
            25  O5x O     5.3509  -18.7720
            26  O5a O    14.7817  -11.6263
            27  C1b C    12.4249  -11.6308
            28  O1a O    11.2650  -12.3007
BOND        31
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21    5  18 1 #Up
            22   14  19 1 #Up
            23   12  20 1 #Up
            24   16  21 1 #Down
            25   17  22 1 #Up
            26   10  23 1 #Down
            27   17  24 1 #Down
            28    2  25 2
            29   22  26 2
            30   22  27 1
            31   27  28 1