Diazepam


Entry
D00293                      Drug                                   
Name
Diazepam (JP18/USP/INN);
Diastat (TN);
Valium (TN)
Product
DIASTAT (Bausch Health US), DIASTAT (Bausch Health US), DIAZEPAM (Meridian Medical Technologies LLC), VALTOCO (Neurelis), VALIUM (Roche Laboratories), VALIUM (Waylis Therapuetics LLC)
  Generic
DIAZEPAM (A-S Medication Solutions), DIAZEPAM (A-S Medication Solutions), DIAZEPAM (A-S Medication Solutions), DIAZEPAM (A-S Medication Solutions), DIAZEPAM (A-S Medication Solutions), DIAZEPAM (A-S Medication Solutions), DIAZEPAM (Advanced Rx Pharmacy of Tennessee), DIAZEPAM (Advanced Rx Pharmacy of Tennessee), DIAZEPAM (Aphena Pharma Solutions - Tennessee), DIAZEPAM (Aphena Pharma Solutions - Tennessee), DIAZEPAM (Aphena Pharma Solutions - Tennessee), DIAZEPAM (Aphena Pharma Solutions - Tennessee), DIAZEPAM (Aphena Pharma Solutions - Tennessee), DIAZEPAM (Aphena Pharma Solutions - Tennessee), DIAZEPAM (Aphena Pharma Solutions - Tennessee), DIAZEPAM (Aphena Pharma Solutions - Tennessee), DIAZEPAM (Aphena Pharma Solutions - Tennessee), DIAZEPAM (Aphena Pharma Solutions - Tennessee), DIAZEPAM (Aphena Pharma Solutions - Tennessee), DIAZEPAM (Bryant Ranch Prepack), DIAZEPAM (Bryant Ranch Prepack), DIAZEPAM (Bryant Ranch Prepack), DIAZEPAM (Bryant Ranch Prepack), DIAZEPAM (Bryant Ranch Prepack), DIAZEPAM (Cardinal Health), DIAZEPAM (Cardinal Health), DIAZEPAM (Civica), DIAZEPAM (Clinical Solutions Wholesale), DIAZEPAM (Clinical Solutions Wholesale), DIAZEPAM (Clinical Solutions Wholesale), DIAZEPAM (Clinical Solutions Wholesale), DIAZEPAM (DIRECT RX), DIAZEPAM (Dash Pharmaceuticals LLC), DIAZEPAM (Dash Pharmaceuticals LLC), DIAZEPAM (DirectRX), DIAZEPAM (Direct_Rx), DIAZEPAM (Direct_Rx), DIAZEPAM (Direct_Rx), DIAZEPAM (Direct_Rx), DIAZEPAM (Direct_Rx), DIAZEPAM (Direct_Rx), DIAZEPAM (General Injectables and Vaccines), DIAZEPAM (General Injectables and Vaccines), DIAZEPAM (Henry Schein), DIAZEPAM (Hikma Pharmaceuticals USA), DIAZEPAM (Hospira), DIAZEPAM (Hospira), DIAZEPAM (Lake Erie Medical DBA Quality Care Products LLC), DIAZEPAM (Lannett Company), DIAZEPAM (Major Pharmaceuticals), DIAZEPAM (Mayne Pharma), DIAZEPAM (McKesson Corporation dba SKY Packaging), DIAZEPAM (Medical Purchasing Solutions), DIAZEPAM (Medical Purchasing Solutions), DIAZEPAM (Medsource Pharmaceuticals), DIAZEPAM (Medsource Pharmaceuticals), DIAZEPAM (Medsource Pharmaceuticals), DIAZEPAM (Mylan Institutional), DIAZEPAM (Mylan Pharmaceuticals), DIAZEPAM (NCS HealthCare of KY), DIAZEPAM (NCS HealthCare of KY), DIAZEPAM (NuCare Pharmaceuticals), DIAZEPAM (NuCare Pharmaceuticals), DIAZEPAM (NuCare Pharmaceuticals), DIAZEPAM (NuCare Pharmaceuticals), DIAZEPAM (NuCare Pharmaceuticals), DIAZEPAM (NuCare Pharmaceuticals), DIAZEPAM (NuCare Pharmaceuticals), DIAZEPAM (Oceanside Pharmaceuticals), DIAZEPAM (PD-Rx Pharmaceuticals), DIAZEPAM (PD-Rx Pharmaceuticals), DIAZEPAM (PD-Rx Pharmaceuticals), DIAZEPAM (PD-Rx Pharmaceuticals), DIAZEPAM (PD-Rx Pharmaceuticals), DIAZEPAM (Pharmaceutical Associates), DIAZEPAM (Precision Dose), DIAZEPAM (Preferred Pharmaceuticals), DIAZEPAM (Preferred Pharmaceuticals), DIAZEPAM (Proficient Rx LP), DIAZEPAM (Proficient Rx LP), DIAZEPAM (Proficient Rx LP), DIAZEPAM (Proficient Rx LP), DIAZEPAM (Quality Care Products LLC), DIAZEPAM (Quality Care Products LLC), DIAZEPAM (REMEDYREPACK), DIAZEPAM (REMEDYREPACK), DIAZEPAM (REMEDYREPACK), DIAZEPAM (REMEDYREPACK), DIAZEPAM (REMEDYREPACK), DIAZEPAM (REMEDYREPACK), DIAZEPAM (RPK Pharmaceuticals), DIAZEPAM (RedPharm Drug), DIAZEPAM (Redpharm Drug), DIAZEPAM (St Mary's Medical Park Pharmacy), DIAZEPAM (St. Mary's Medical Park Pharmacy), DIAZEPAM (Teva Pharmaceuticals USA), DIAZEPAM (West-Ward Pharmaceuticals Corp.), DIAZEPAM INTENSOL (West-Ward Pharmaceuticals Corp.), DIAZEPAM (Chartwell RX)
Formula
C16H13ClN2O
Exact mass
284.0716
Mol weight
284.7402
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01835  Benzodiazepine sedative-hypnotics
 DG01567  GABA-A receptor agonist
 DG01914  Anxiolytics, benzodiazepine derivatives
 DG03199  Antiepileptic agent
Metabolizing enzyme substrate
 DG01639  CYP2C19 substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
Same as: C06948
Therapeutic category: 1124 1139
ATC code: N05BA01
Product: D00293<JP/US>
Efficacy
Antianxiety, Minor tranquilizer, Sedative-hypnotic
  Disease
Anxiety disorders [DS:H01662]
Comment
Benzodiazepine derivative
Target
GABR [HSA:2554 2555 2556 2557 2558 2559 2560 2561 2562 2563 2564 2565 2566 2567 2568 55879] [KO:K05175 K05181 K05184 K05185 K05186 K05189 K05192]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04727  GABAergic synapse
Metabolism
Enzyme: CYP2C19 [HSA:1557], CYP3A4 [HSA:1576]
Interaction
Structure map
map07030  Anxiolytics
map07032  Hypnotics
map07033  Anticonvulsants
map07117  Benzodiazepine family
map07230  GABA-A receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05B ANXIOLYTICS
    N05BA Benzodiazepine derivatives
     N05BA01 Diazepam
      D00293  Diazepam (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Anticonvulsants
  Gamma-aminobutyric Acid (GABA) Augmenting Agents
   Benzodiazepines
    Diazepam
     D00293  Diazepam (JP18/USP/INN)
 Anxiolytics
  Benzodiazepines
   Diazepam
    D00293  Diazepam (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   112  Hypnotics and sedatives, anxiolytics
    1124  Benzodiazepins
     D00293  Diazepam (JP18/USP/INN)
   113  Antiepileptics
    1139  Others
     D00293  Diazepam (JP18/USP/INN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01835  Benzodiazepine sedative-hypnotics
   D00293  Diazepam
  DG01567  GABA-A receptor agonist
   D00293  Diazepam
  DG01914  Anxiolytics, benzodiazepine derivatives
   D00293  Diazepam
  DG03199  Antiepileptic agent
   D00293  Diazepam
 Metabolizing enzyme substrate
  DG01639  CYP2C19 substrate
   D00293  Diazepam
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D00293  Diazepam
Target-based classification of drugs [BR:br08310]
 Ion channels
  Ligand-gated ion channels
   GABA (ionotropic)
    GABR
     D00293  Diazepam (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00293  Diazepam
  D00293  Diazepam tablets
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00293
Pharmacogenomic biomarkers [br08341.html]
 Polymorphisms and mutations affecting drug response
  D00293
Other DBs
CAS: 439-14-5
PubChem: 7847359
ChEBI: 49575
PDB-CCD: DZP[PDBj]
LigandBox: D00293
NIKKAJI: J2.044C
KCF data

ATOM        20
            1   C2y C    17.4934  -14.8494
            2   C8y C    16.6513  -13.7398
            3   C8y C    16.9865  -12.3830
            4   N1y N    18.2475  -11.8049
            5   N2x N    18.8992  -14.8746
            6   C5x C    19.5011  -12.4272
            7   C1x C    19.7876  -13.7959
            8   C8x C    15.9794  -11.4146
            9   C8x C    14.6374  -11.8027
            10  C8y C    14.3022  -13.1595
            11  C8x C    15.3093  -14.1276
            12  O5x O    20.5452  -11.4928
            13  X   Cl   12.9374  -13.5539
            14  C8y C    16.8589  -16.0991
            15  C8x C    15.4573  -16.0991
            16  C1a C    18.2692  -10.4300
            17  C8x C    14.7573  -17.3116
            18  C8x C    15.4573  -18.5240
            19  C8x C    16.8589  -18.5240
            20  C8x C    17.5589  -17.3116
BOND        22
            1     3   4 1
            2     1   5 2
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    2  11 2
            13    6  12 2
            14   10  13 1
            15    1  14 1
            16   14  15 1
            17    4  16 1
            18   15  17 2
            19   17  18 1
            20   18  19 2
            21   19  20 1
            22   14  20 2