Entry

D00307                      Drug

Name

Doxycycline (USP);
Doxycycline hydrate;
Monodox (TN);
Oracea (TN);
Vibramycin (TN)

Product

ORACEA (Galderma Laboratories), DOXYCYCLINE HYCLATE (Pfizer Laboratories Div Pfizer), DOXYCYCLINE MONOHYDRATE (Chartwell RX)

Generic

DOXYCYCLINE (A-S Medication Solutions), DOXYCYCLINE (A-S Medication Solutions), DOXYCYCLINE (A-S Medication Solutions), DOXYCYCLINE (A-S Medication Solutions), DOXYCYCLINE (A-S Medication Solutions), DOXYCYCLINE (A-S Medication Solutions), DOXYCYCLINE (Alembic Pharmaceuticals), DOXYCYCLINE (Alembic Pharmaceuticals Limited), DOXYCYCLINE (American Health Packaging), DOXYCYCLINE (American Health Packaging), DOXYCYCLINE HYCLATE (Amneal Pharmaceuticals NY LLC), DOXYCYCLINE (Amneal Pharmaceuticals of New York LLC), DOXYCYCLINE MONOHYDRATE (Aphena Pharma Solutions - Tennessee), DOXYCYCLINE (AvKARE), DOXYCYCLINE (AvPAK), DOXYCYCLINE (Bryant Ranch Prepack), DOXYCYCLINE (Bryant Ranch Prepack), DOXYCYCLINE (Bryant Ranch Prepack), DOXYCYCLINE (Bryant Ranch Prepack), DOXYCYCLINE (Bryant Ranch Prepack), DOXYCYCLINE (Bryant Ranch Prepack), DOXYCYCLINE (Bryant Ranch Prepack), DOXYCYCLINE (Bryant Ranch Prepack), DOXYCYCLINE (Cadila Healthcare Limited), DOXYCYCLINE (Chartwell Governmental & Specialty RX), DOXYCYCLINE (Cosette Pharmaceuticals), DOXYCYCLINE (Cosette Pharmaceuticals), DOXYCYCLINE (DIRECT RX), DOXYCYCLINE (Denton Pharma), DOXYCYCLINE (Denton Pharma), DOXYCYCLINE (Denton Pharma), DOXYCYCLINE (Denton Pharma), DOXYCYCLINE (Direct Rx), DOXYCYCLINE (Golden State Medical Supply), DOXYCYCLINE (Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals), DOXYCYCLINE (Lake Erie Medical DBA Quality Care Products LLC), DOXYCYCLINE (Lannett Company), DOXYCYCLINE (Lupin Pharmaceuticals), DOXYCYCLINE (Lupin Pharmaceuticals), DOXYCYCLINE (Lupin Pharmaceuticals), DOXYCYCLINE (Novel Laboratories), DOXYCYCLINE (NuCare Pharmaceuticals), DOXYCYCLINE (PD-Rx Pharmaceuticals), DOXYCYCLINE (PD-Rx Pharmaceuticals), DOXYCYCLINE (PD-Rx Pharmaceuticals), DOXYCYCLINE (PD-Rx Pharmaceuticals), DOXYCYCLINE (Par Pharmaceutical), DOXYCYCLINE (PharmPak), DOXYCYCLINE (Prasco Laboratories), DOXYCYCLINE (Proficient Rx LP), DOXYCYCLINE (Proficient Rx LP), DOXYCYCLINE (Proficient Rx LP), DOXYCYCLINE (Proficient Rx LP), DOXYCYCLINE (Proficient Rx LP), DOXYCYCLINE (Proficient Rx LP), DOXYCYCLINE (Quality Care Products), DOXYCYCLINE (REMEDYREPACK), DOXYCYCLINE (REMEDYREPACK), DOXYCYCLINE (REMEDYREPACK), DOXYCYCLINE (REMEDYREPACK), DOXYCYCLINE (RPK Pharmaceuticals), DOXYCYCLINE MONOHYDRATE (RPK Pharmaceuticals), DOXYCYCLINE (RPK Pharmaceuticals), DOXYCYCLINE (RedPharm Drug), DOXYCYCLINE (RedPharm Drug), DOXYCYCLINE (RedPharm Drug), DOXYCYCLINE (RedPharm Drug), DOXYCYCLINE (RedPharm Drug), DOXYCYCLINE (RedPharm Drug), DOXYCYCLINE (Strides Pharma Science Limited), DOXYCYCLINE (Sun Pharmaceutical Industries), DOXYCYCLINE (Sun Pharmaceutical Industries), DOXYCYCLINE (Zydus Lifesciences Limited), DOXYCYCLINE (Zydus Pharmaceuticals (USA)), DOXYCYCLINE (Zydus Pharmaceuticals (USA)), DOXYCYCLINE MONOHYDRATE (Direct_Rx)

Formula

C22H24N2O8. H2O

Exact mass

462.1638

Mol weight

462.4498

Structure

Simcomp

Class

Antibacterial
DG01197 Tetracycline antibiotic

Remark

ATC code:

A01AB22 J01AA02

Chemical structure group:

DG00008

Product (DG00008):

D00307<US> D02129<JP/US>

Efficacy

Antibacterial, Protein biosynthesis inhibitor

Disease

Rocky Mountain spotted fever [DS:H00323]
Typhus fever [DS:H00322]
Q fever [DS:H00310]
Rickettsialpox [DS:H02379]
Lymphogranuloma venereum [DS:H00348]
Psittacosis [DS:H00350]
Trachoma [DS:H00349]
Relapsing fever [DS:H00427]
Chancroid [DS:H00305]
Plague [DS:H00297]
Tularemia [DS:H00312]
Cholera [DS:H00110]
Campylobacter fetus infections [DS:H00321]
Brucellosis [DS:H00325]
Bartonellosis [DS:H00326]
Granuloma inguinale [DS:H01415]
Anthrax [DS:H00328]
Gonorrhea [DS:H00315]
Syphilis [DS:H00354]
Yaws [DS:H01318]
Listeriosis [DS:H00332]
Vincent's infection [DS:H01440]
Actinomycosis [DS:H01325]
Amebiasis [DS:H00360]
Severe acne [DS:H01445]

Target

30S ribosomal subunit

Pathway

ko03010

Ribosome

Interaction

Structure map

map07019

Tetracyclines

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AB Antiinfectives and antiseptics for local oral treatment
     A01AB22 Doxycycline
      D00307  Doxycycline (USP) <US>
J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01A TETRACYCLINES
    J01AA Tetracyclines
     J01AA02 Doxycycline
      D00307  Doxycycline (USP) <US>
USP drug classification [BR:br08302]
Antibacterials
  Tetracyclines
   Doxycycline
    D00307  Doxycycline (USP)
Dental and Oral Agents
  Doxycycline
   D00307  Doxycycline (USP)
Drug groups [BR:br08330]
Antibacterial
  DG01197  Tetracycline antibiotic
   DG00008  Doxycycline
    D00307  Doxycycline
Drug classes [BR:br08332]
Antibacterial
  DG01197  Tetracycline antibiotic
   D00307  Doxycycline
Antimicrobials [BR:br08307]
Antibacterials
  Protein biosynthesis inhibitor
   Tetracycline
    D00307  Doxycycline (USP) <US>
Drug groups [BR:br08330]
Antibacterial
  DG01197  Tetracycline antibiotic
   DG00008  Doxycycline
Antimicrobials abbreviations [BR:br08327]
Antibacterials
  Protein biosynthesis inhibitor
   Tetracycline
    DG00008  Doxycycline

Other DBs

CAS:	17086-28-1

PubChem:

7847373

ChEBI:

60648

LigandBox:

D00307

NIKKAJI:

J243.853D

KCF data

ATOM        33
            1   C1y C    21.1216  -16.6614
            2   C1z C    21.1506  -18.0502
            3   C1y C    22.3391  -15.9818
            4   C1y C    19.9277  -15.9523
            5   C2y C    19.8983  -18.7358
            6   C5x C    22.2978  -18.7653
            7   C2y C    23.5269  -16.6969
            8   C1y C    18.7103  -16.6379
            9   C2y C    18.6985  -18.0324
            10  O1a O    19.8924  -20.1364
            11  C2y C    23.5151  -18.0857
            12  O5x O    22.3208  -20.1660
            13  O1a O    24.7564  -16.0173
            14  C1y C    17.5048  -15.9345
            15  C5x C    17.4929  -18.7298
            16  C5a C    24.7149  -18.8068
            17  C8y C    16.2990  -16.6261
            18  C8y C    16.2931  -18.0265
            19  O5x O    17.4929  -20.1245
            20  N1a N    25.9383  -18.1212
            21  O5a O    24.7439  -20.2073
            22  C8x C    15.0755  -15.9286
            23  C8y C    15.0815  -18.7240
            24  C8x C    13.8699  -16.6319
            25  C8x C    13.8699  -18.0324
            26  O1a O    15.0815  -20.1245
            27  C1a C    17.5101  -14.1705
            28  N1c N    22.3622  -13.7280
            29  C1a C    23.5981  -13.0412
            30  C1a C    21.1494  -13.0011
            31  O1a O    19.9173  -14.1846
            32  O1a O    21.0956  -19.4620
            33  O0  O    29.6802  -17.2901
BOND        35
            1     5   9 2
            2     5  10 1
            3     6  11 1
            4     6  12 2
            5     7  13 1
            6     8  14 1
            7     9  15 1
            8    11  16 1
            9    14  17 1
            10   15  18 1
            11   15  19 2
            12   16  20 1
            13   16  21 2
            14   17  22 1
            15   18  23 1
            16   22  24 2
            17   23  25 2
            18   23  26 1
            19    7  11 2
            20    8   9 1
            21   17  18 2
            22   24  25 1
            23   14  27 1 #Down
            24    3  28 1 #Down
            25    1   2 1
            26   28  29 1
            27    1   3 1
            28   28  30 1
            29    1   4 1
            30    2   5 1
            31    2   6 1
            32    4  31 1 #Down
            33    3   7 1
            34    2  32 1 #Down
            35    4   8 1