Estazolam

Entry

D00311                      Drug

Name

Estazolam (JP18/USP/INN);
ProSom (TN)

Product

Generic

ESTAZOLAM (Actavis Pharma), ESTAZOLAM (Mayne Pharma), ESTAZOLAM (Novitium Pharma LLC)

Formula

C16H11ClN4

Exact mass

294.0672

Mol weight

294.7383

Structure

Simcomp

Class

Neuropsychiatric agent
DG01835  Benzodiazepine sedative-hypnotics
DG03202  Hypnotic
DG01567  GABA-A receptor agonist
Metabolizing enzyme substrate
DG01633  CYP3A/CYP3A4 substrate

Remark

Same as:

C06981

Therapeutic category:

1124

ATC code:

N05CD04

Product:

D00311<JP/US>

Efficacy

Sedative-hypnotic

Disease

Insomnia [DS:H01609]

Comment

Benzodiazepine derivative

Target

GABR [HSA:2554 2555 2556 2557 2558 2559 2560 2561 2562 2563 2564 2565 2566 2567 2568 55879] [KO:K05175 K05181 K05184 K05185 K05186 K05189 K05192]

Pathway

hsa04080

Neuroactive ligand-receptor interaction

hsa04727

GABAergic synapse

Metabolism

Enzyme: CYP3A [HSA:1576 1577 1551]

Interaction

Structure map

map07032

Hypnotics

map07230

GABA-A receptor agonists/antagonists

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05C HYPNOTICS AND SEDATIVES
    N05CD Benzodiazepine derivatives
     N05CD04 Estazolam
      D00311  Estazolam (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Sleep Disorder Agents
  Sleep Promoting Agents
   Estazolam
    D00311  Estazolam (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   112  Hypnotics and sedatives, anxiolytics
    1124  Benzodiazepins
     D00311  Estazolam (JP18/USP/INN)
Drug groups [BR:br08330]
Neuropsychiatric agent
  DG01835  Benzodiazepine sedative-hypnotics
   D00311  Estazolam
  DG03202  Hypnotic
   D00311  Estazolam
  DG01567  GABA-A receptor agonist
   D00311  Estazolam
Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   D00311  Estazolam
Drug classes [BR:br08332]
Neuropsychiatric agent
  DG03202  Hypnotic
   D00311  Estazolam
Target-based classification of drugs [BR:br08310]
Ion channels
  Ligand-gated ion channels
   GABA (ionotropic)
    GABR
     D00311  Estazolam (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
  D00311  Estazolam
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
  D00311

Other DBs

CAS:	29975-16-4

PubChem:

7847377

ChEBI:

4858

LigandBox:

D00311

NIKKAJI:

J9.280K

KCF data

ATOM        21
            1   C2y C    14.0634  -14.3594
            2   C8y C    13.2213  -13.2498
            3   C8y C    13.5565  -11.8930
            4   N4y N    14.8175  -11.3149
            5   N2x N    15.4692  -14.3846
            6   C8y C    16.0711  -11.9372
            7   C1x C    16.3576  -13.3059
            8   C8x C    12.5494  -10.9246
            9   C8x C    11.2074  -11.3127
            10  C8y C    10.8722  -12.6695
            11  C8x C    11.8793  -13.6376
            12  X   Cl    9.5074  -13.0639
            13  C8y C    13.4289  -15.6091
            14  C8x C    12.0273  -15.6091
            15  C8x C    11.3273  -16.8216
            16  C8x C    12.0273  -18.0340
            17  C8x C    13.4289  -18.0340
            18  C8x C    14.1289  -16.8216
            19  N5x N    17.0504  -10.9373
            20  N5x N    16.4020   -9.5570
            21  C8x C    14.8175   -9.9149
BOND        24
            1     3   4 1
            2     1   5 2
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    2  11 2
            13   10  12 1
            14    1  13 1
            15   13  14 1
            16   14  15 2
            17   15  16 1
            18   16  17 2
            19   17  18 1
            20   13  18 2
            21    6  19 2
            22   19  20 1
            23    4  21 1
            24   21  20 2