Famciclovir


Entry
D00317                      Drug                                   
Name
Famciclovir (JAN/USP/INN);
Famvir (TN)
  Abbr
FCV
Product
  Generic
FAMCICLOVIR (ATLANTIC BIOLOGICALS CORP.), FAMCICLOVIR (Apotex Corp.), FAMCICLOVIR (Aurobindo Pharma Limited), FAMCICLOVIR (AvKARE), FAMCICLOVIR (Bryant Ranch Prepack), FAMCICLOVIR (Camber Pharmaceuticals), FAMCICLOVIR (Golden State Medical Supply), FAMCICLOVIR (Macleods Pharmaceuticals Limited), FAMCICLOVIR (PD-Rx Pharmaceuticals), FAMCICLOVIR (Proficient Rx LP), FAMCICLOVIR (Proficient Rx LP), FAMCICLOVIR (Proficient Rx LP), FAMCICLOVIR (Rising Pharmaceuticals), FAMCICLOVIR (Teva Pharmaceuticals USA)
Formula
C14H19N5O4
Exact mass
321.1437
Mol weight
321.3318
Structure
Class
Antiviral
 DG02840  Anti-herpesvirus agent
Remark
Therapeutic category: 6250
ATC code: J05AB09 S01AD07
Product: D00317<JP/US>
Efficacy
Antiviral, DNA polymerase inhibitor
  Disease
Herpes labialis, Genital herpes [DS:H00365]
Herpes zoster [DS:H00366]
Comment
Active form of prodrug: Penciclovir [DR:D05407]
Target
Herpesvirus DNA polymerase [KO:K18964]
  Pathway
ko03240  Viral replication
Interaction
Structure map
map07044  Antiviral agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J05 ANTIVIRALS FOR SYSTEMIC USE
   J05A DIRECT ACTING ANTIVIRALS
    J05AB Nucleosides and nucleotides excl. reverse transcriptase inhibitors
     J05AB09 Famciclovir
      D00317  Famciclovir (JAN/USP/INN) <JP/US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AD Antivirals
     S01AD07 Famciclovir
      D00317  Famciclovir (JAN/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Antivirals
  Antiherpetic Agents
   Famciclovir
    D00317  Famciclovir (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   625  Antivirals
    6250  Antivirals
     D00317  Famciclovir (JAN/USP/INN)
Drug groups [BR:br08330]
 Antiviral
  DG02840  Anti-herpesvirus agent
   D00317  Famciclovir
Drug classes [BR:br08332]
 Antiviral
  DG02840  Anti-herpesvirus agent
   D00317  Famciclovir
Antimicrobials [BR:br08307]
 Antivirals
  Genome replication inhibitor
   Herpesvirus DNA polymerase inhibitor
    D00317  Famciclovir (JAN/USP/INN) <JP/US>
Antimicrobials abbreviations [BR:br08327]
 Antivirals
  Genome replication inhibitor
   Herpesvirus DNA polymerase inhibitor
    D00317  Famciclovir (JAN/USP/INN)
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D00317
Prodrugs [br08324.html]
 D00317
Other DBs
CAS: 104227-87-4
PubChem: 7847383
ChEBI: 4974
LigandBox: D00317
NIKKAJI: J435.369B
KCF data

ATOM        23
            1   C8y C    21.2800  -21.7700
            2   C8y C    21.2800  -20.3700
            3   N4y N    19.8800  -22.1900
            4   N5x N    22.4700  -22.5400
            5   N5x N    19.9500  -19.9500
            6   C8x C    22.4700  -19.7400
            7   C8x C    19.1100  -21.0700
            8   C8y C    23.7300  -21.8400
            9   N5x N    23.7300  -20.4400
            10  N1a N    24.8500  -22.6100
            11  C1b C    19.8800  -23.5900
            12  C1b C    18.6900  -24.2900
            13  C1c C    17.5000  -23.5900
            14  C1b C    16.3100  -24.2900
            15  C1b C    17.5000  -22.1900
            16  O7a O    16.3100  -21.4900
            17  O7a O    15.1200  -23.5900
            18  C7a C    13.8600  -24.2900
            19  C1a C    12.7400  -23.5900
            20  O6a O    13.8600  -25.6900
            21  C7a C    16.3214  -20.0900
            22  O6a O    17.5308  -19.4048
            23  C1a C    15.1062  -19.3752
BOND        24
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     4   8 2
            8     6   9 2
            9     8  10 1
            10    5   7 2
            11    8   9 1
            12    3  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   13  15 1
            17   15  16 1
            18   14  17 1
            19   17  18 1
            20   18  19 1
            21   18  20 2
            22   16  21 1
            23   21  22 2
            24   21  23 1