Famotidine


Entry
D00318                      Drug                                   
Name
Famotidine (JP18/USP/INN);
Fluxid (TN);
Pepcid (TN)
Product
  Generic
FAMOTIDINE (A-S Medication Solutions), FAMOTIDINE (A-S Medication Solutions), FAMOTIDINE (A-S Medication Solutions), FAMOTIDINE (A-S Medication Solutions), FAMOTIDINE (A-S Medication Solutions), FAMOTIDINE (Akorn), FAMOTIDINE (Alembic Pharmaceuticals), FAMOTIDINE (Alembic Pharmaceuticals Limited), FAMOTIDINE (American Health Packaging), FAMOTIDINE (Amneal Pharmaceuticals NY LLC), FAMOTIDINE (Aphena Pharma Solutions - Tennessee), FAMOTIDINE (Aphena Pharma Solutions - Tennessee), FAMOTIDINE (Ascend Laboratories), FAMOTIDINE (Ascent Pharmaceuticals), FAMOTIDINE (Athenex Pharmaceutical Division), FAMOTIDINE (Aurobindo Pharma Limited), FAMOTIDINE (AvKARE), FAMOTIDINE (AvPAK), FAMOTIDINE (AvPAK), PEPCID (Bausch Health Americas), FAMOTIDINE (Baxter Healthcare Corporation), FAMOTIDINE (BluePoint Laboratories), FAMOTIDINE (Bryant Ranch Prepack), FAMOTIDINE (Bryant Ranch Prepack), FAMOTIDINE (Bryant Ranch Prepack), FAMOTIDINE (Bryant Ranch Prepack), FAMOTIDINE (Bryant Ranch Prepack), FAMOTIDINE (Bryant Ranch Prepack), FAMOTIDINE (Bryant Ranch Prepack), FAMOTIDINE (Bryant Ranch Prepack), FAMOTIDINE (Bryant Ranch Prepack), FAMOTIDINE (Bryant Ranch Prepack), FAMOTIDINE (Bryant Ranch Prepack), FAMOTIDINE (Bryant Ranch Prepack), FAMOTIDINE (CELLTRION USA), FAMOTIDINE (Camber Pharmaceuticals), FAMOTIDINE (Cardinal Health), FAMOTIDINE (Carlsbad Technology), FAMOTIDINE (Clinical Solutions Wholesale), FAMOTIDINE (DIRECT RX), FAMOTIDINE (Denton Pharma), FAMOTIDINE (Denton Pharma), FAMOTIDINE (Denton Pharma), FAMOTIDINE (Denton Pharma), FAMOTIDINE (Direct Rx), FAMOTIDINE (Direct_Rx), FAMOTIDINE (Direct_Rx), FAMOTIDINE (Dr.Reddy's Laboratories Limited), FAMOTIDINE (Fresenius Kabi USA), FAMOTIDINE (Fresenius Kabi USA), FAMOTIDINE (Fresenius Kabi USA), FAMOTIDINE (Golden State Medical Supply), FAMOTIDINE (Golden State Medical Supply), FAMOTIDINE (HF Acquisition Co LLC), FAMOTIDINE (Hikma Pharmaceuticals USA), FAMOTIDINE (Legacy Pharmaceutical Packaging), FAMOTIDINE (Legacy Pharmaceutical Packaging), FAMOTIDINE (Lupin Pharmaceuticals), FAMOTIDINE (Lupin Pharmaceuticals), FAMOTIDINE (Major Pharmaceuticals), FAMOTIDINE (Mckesson Corporation DBA SKY Packaginng), FAMOTIDINE (Medical Purchasing Solutions), FAMOTIDINE (Medical Purchasing Solutions), FAMOTIDINE (Mylan Institutional LLC), FAMOTIDINE (NCS HealthCare of KY), FAMOTIDINE (NCS HealthCare of KY), FAMOTIDINE (Northstar Rx LLC), FAMOTIDINE (Northwind Pharmaceuticals), FAMOTIDINE (Novitium Pharma LLC), FAMOTIDINE (NuCare Pharmaceutical), FAMOTIDINE (NuCare Pharmaceuticals), FAMOTIDINE (NuCare Pharmaceuticals), FAMOTIDINE (NuCare Pharmaceuticals), FAMOTIDINE (NuCare Pharmaceuticals), FAMOTIDINE (NuCare Pharmaceuticals), FAMOTIDINE (PD-Rx Pharmaceuticals), FAMOTIDINE (PD-Rx Pharmaceuticals), FAMOTIDINE (PD-Rx Pharmaceuticals), FAMOTIDINE (PD-Rx Pharmaceuticals), FAMOTIDINE (PD-Rx Pharmaceuticals), FAMOTIDINE (Preferred Pharmaceuticals), FAMOTIDINE (Preferred Pharmaceuticals), FAMOTIDINE (Preferred Pharmaceuticals), FAMOTIDINE (Preferred Pharmaceuticals), FAMOTIDINE (Proficient Rx LP), FAMOTIDINE (Proficient Rx LP), FAMOTIDINE (Proficient Rx LP), FAMOTIDINE (Proficient Rx LP), FAMOTIDINE (Proficient Rx LP), FAMOTIDINE (Proficient Rx LP), FAMOTIDINE (Proficient Rx LP), FAMOTIDINE (REMEDYREPACK), FAMOTIDINE (REMEDYREPACK), FAMOTIDINE (REMEDYREPACK), FAMOTIDINE (REMEDYREPACK), FAMOTIDINE (REMEDYREPACK), FAMOTIDINE (REMEDYREPACK), FAMOTIDINE (RPK Pharmaceuticals), FAMOTIDINE (RPK Pharmaceuticals), FAMOTIDINE (RPK Pharmaceuticals), FAMOTIDINE (RPK Pharmaceuticals), FAMOTIDINE (RedPharm Drug), FAMOTIDINE (RedPharm Drug), FAMOTIDINE (RedPharm Drug), FAMOTIDINE (RedPharm Drug), FAMOTIDINE (RedPharm Drug), FAMOTIDINE (St. Mary's Medical Park Pharmacy), FAMOTIDINE (St. Mary's Medical Park Pharmacy), FAMOTIDINE (Teva Pharmaceuticals USA), FAMOTIDINE (Unit Dose Services), FAMOTIDINE (XLCare Pharmaceuticals), FAMOTIDINE (Zydus Lifesciences Limited), FAMOTIDINE (Zydus Pharmaceuticals USA), FAMOTIDINE (Zydus Pharmaceuticals USA), FAMOTIDINE (direct rx), FAMOTIDINE (direct rx), FAMOTIDINE (medsource pharmaceuticals)
Formula
C8H15N7O2S3
Exact mass
337.0449
Mol weight
337.4454
Structure
Class
Gastrointestinal agent
 DG01975  Agents for peptic ulcer
  DG01481  Histamine receptor H2 antagonist
Metabolizing enzyme inhibitor
 DG01634  CYP1A2 inhibitor
Transporter substrate
 DG02854  SLC22A2 substrate
 DG02860  SLC22A8 substrate
Transporter inhibitor
 DG02863  SLC22A2 inhibitor
 DG02881  SLC22A3 inhibitor
Remark
Therapeutic category: 2325
ATC code: A02BA03
Product: D00318<JP/US>
Product (mixture): D11575<US>
Efficacy
Anti-ulcerative, H2 receptor antagonist
  Disease
Duodenal ulcer [DS:H01634]
Gastric ulcer [DS:H01634]
Gastroesophageal reflux disease [DS:H01602]
Zollinger-Ellison syndrome [DS:H01522]
Target
HRH2 [HSA:3274] [KO:K04150]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04971  Gastric acid secretion
Metabolism
Transporter: SLC22A2 [HSA:6582], SLC22A8 [HSA:9376]
Interaction
CYP inhibition: CYP1A2 [HSA:1544]
Transporter inhibition: SLC22A2 [HSA:6582], SLC22A3 [HSA:6581]
Structure map
map07038  Antiulcer drugs
map07227  Histamine H2/H3 receptor agonists/antagonists
Other map
map04976  Bile secretion
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A02 DRUGS FOR ACID RELATED DISORDERS
   A02B DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
    A02BA H2-receptor antagonists
     A02BA03 Famotidine
      D00318  Famotidine (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Gastrointestinal Agents
  Histamine2 (H2) Receptor Antagonists
   Famotidine
    D00318  Famotidine (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  23  Digestive organ agents
   232  Peptic ulcer agents
    2325  H2 blockers
     D00318  Famotidine (JP18/USP/INN)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for digestive organs
  09 Histamine H2 receptor blocker containing drugs
   D00318  Famotidine (JP18/USP/INN)
Risk category of Japanese OTC drugs [BR:br08312]
 First-class OTC drugs
  Inorganic and organic chemicals
   Famotidine
    D00318  Famotidine (JP18/USP/INN)
Drug groups [BR:br08330]
 Gastrointestinal agent
  DG01975  Agents for peptic ulcer
   DG01481  Histamine receptor H2 antagonist
    D00318  Famotidine
 Metabolizing enzyme inhibitor
  DG01634  CYP1A2 inhibitor
   D00318  Famotidine
 Transporter substrate
  DG02854  SLC22A2 substrate
   D00318  Famotidine
  DG02860  SLC22A8 substrate
   D00318  Famotidine
 Transporter inhibitor
  DG02863  SLC22A2 inhibitor
   D00318  Famotidine
  DG02881  SLC22A3 inhibitor
   D00318  Famotidine
Drug classes [BR:br08332]
 Gastrointestinal agent
  DG01481  Histamine receptor H2 antagonist
   D00318  Famotidine
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    HRH2
     D00318  Famotidine (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00318  Famotidine
  D00318  Famotidine tablets
  D00318  Famotidine powder
  D00318  Famotidine injection
  D00318  Famotidine for injection
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00318
 Drug transporters
  D00318
Rx-to-OTC switch list in the USA [br08315.html]
 D00318
Rx-to-OTC switch list in Japan [br08314.html]
 D00318
Other DBs
CAS: 76824-35-6
PubChem: 7847384
ChEBI: 4975
LigandBox: D00318
NIKKAJI: J22.992J
KCF data

ATOM        20
            1   C1b C    21.2100  -23.8000
            2   S2a S    22.4700  -23.1000
            3   C1b C    23.6600  -23.8000
            4   C1b C    24.8500  -23.1000
            5   C2c C    26.1100  -23.8000
            6   N2b N    27.3000  -23.1000
            7   C8y C    20.0200  -23.1000
            8   N5x N    20.0200  -21.7000
            9   C8y C    18.6900  -21.2800
            10  S2x S    17.8500  -22.4000
            11  C8x C    18.6900  -23.5200
            12  N2b N    18.2620  -19.9470
            13  C2c C    16.9019  -19.6530
            14  N1a N    15.9389  -20.7155
            15  N1a N    16.4756  -18.3267
            16  N1a N    26.1272  -25.1999
            17  S4a S    28.5181  -23.7901
            18  O3c O    29.6995  -23.0950
            19  O3c O    28.4598  -25.1994
            20  N1a N    29.7021  -24.5005
BOND        20
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 2
            6     1   7 1
            7     7   8 1
            8     8   9 2
            9     9  10 1
            10   10  11 1
            11    7  11 2
            12    9  12 1
            13   12  13 2
            14   13  14 1
            15   13  15 1
            16    5  16 1
            17    6  17 1
            18   17  18 2
            19   17  19 2
            20   17  20 1