Entry

D00325                      Drug

Name

Fluocinonide (JP18/USP/INN);
Lidex (TN);
Vanos (TN)

Product

FLUOCINONIDE (Alvogen), FLUOCINONIDE (Alvogen), VANOS (Bausch Health US), FLUOCINONIDE (NuCare Pharmaceuticals), FLUOCINONIDE (NuCare Pharmaceuticals), FLUOCINONIDE (Proficient Rx LP), FLUOCINONIDE (Taro Pharmaceuticals U.S.A.), FLUOCINONIDE GEL (Alvogen)

Generic

FLUOCINONIDE (A-S Medication Solutions), FLUOCINONIDE (A-S Medication Solutions), FLUOCINONIDE (A-S Medication Solutions), FLUOCINONIDE (A-S Medication Solutions), FLUOCINONIDE (A-S Medication Solutions), FLUOCINONIDE (Amneal Pharmaceuticals NY LLC), FLUOCINONIDE CREAM (Amneal Pharmaceuticals NY LLC), FLUOCINONIDE (Bryant Ranch Prepack), FLUOCINONIDE (Bryant Ranch Prepack), FLUOCINONIDE (Bryant Ranch Prepack), FLUOCINONIDE (Bryant Ranch Prepack), FLUOCINONIDE (Bryant Ranch Prepack), FLUOCINONIDE (Bryant Ranch Prepack), FLUOCINONIDE (Cadila Healthcare Limited), FLUOCINONIDE (Cadila Healthcare Limited), FLUOCINONIDE (Cosette Pharmaceuticals), FLUOCINONIDE (Cosette Pharmaceuticals), FLUOCINONIDE (E. Fougera & Co. a division of Fougera Pharmaceuticals), FLUOCINONIDE (Fougera Pharmaceuticals), FLUOCINONIDE (Fougera Pharmaceuticals), FLUOCINONIDE (Glasshouse Pharmaceuticals Limited Canada), FLUOCINONIDE (Glenmark Pharmaceuticals), FLUOCINONIDE (IPG PHARMACEUTICALS), FLUOCINONIDE (IPG PHARMACEUTICALS), FLUOCINONIDE (IPG PHARMACEUTICALS), FLUOCINONIDE (Lupin Pharmaceuticals), FLUOCINONIDE (Lupin Pharmaceuticals), FLUOCINONIDE (Macleods Pharmaceuticals Limited), FLUOCINONIDE (Mayne Pharma), FLUOCINONIDE (Novel Laboratories), FLUOCINONIDE (Novel Laboratories), FLUOCINONIDE (NuCare Pharmaceuticals), FLUOCINONIDE (NuCare Pharmaceuticals), FLUOCINONIDE (NuCare Pharmaceuticals), FLUOCINONIDE (NuCare Pharmaceuticals), FLUOCINONIDE (NuCare Pharmaceuticals), FLUOCINONIDE (NuCare Pharmaceuticals), FLUOCINONIDE (NuCare Pharmaceuticals), FLUOCINONIDE (NuCare Pharmaceuticals), FLUOCINONIDE CREAM (NuCare Pharmaceuticals), FLUOCINONIDE CREAM (NuCare Pharmceuticals), FLUOCINONIDE (Oceanside Pharmaceuticals), FLUOCINONIDE (Padagis Israel Pharmaceuticals), FLUOCINONIDE CREAM (Preferred Pharmaceuticals), FLUOCINONIDE (Proficient Rx LP), FLUOCINONIDE (RPK Pharmaceuticals), FLUOCINONIDE (RPK Pharmaceuticals), FLUOCINONIDE (RPK Pharmaceuticals), FLUOCINONIDE (Taro Pharmaceuticals U.S.A.), FLUOCINONIDE (Taro Pharmaceuticals U.S.A.), FLUOCINONIDE (Taro Pharmaceuticals U.S.A.), FLUOCINONIDE (Teligent Pharma), FLUOCINONIDE (Teligent Pharma), FLUOCINONIDE (Teligent Pharma), FLUOCINONIDE (Teligent Pharma), FLUOCINONIDE (Teva Pharmaceuticals USA), FLUOCINONIDE (Viona Pharmaceuticals), FLUOCINONIDE (Xiromed LLC), FLUOCINONIDE (Zydus Pharmaceuticals (USA)), FLUOXIV (Primary Pharmaceuticals), FLUOVIX PLUS (Primary Pharmaceuticals), FLUMETHOVIX (Primary Pharmaceuticals), FLUOCINONIDE GEL (SOLA Pharmaceuticals), FLUOCINONIDE (Encube Ethicals Private Limited), FLUOCINONIDE (Rising Pharmaceuticals)

Formula

C26H32F2O7

Exact mass

494.2116

Mol weight

494.5249

Structure

Simcomp

Class

Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid

Remark

Same as:

C07007

Therapeutic category:

2646

ATC code:

C05AA11 D07AC08

Product:

D00325<JP/US>

Efficacy

Anti-inflammatory, Glucocorticoid receptor agonist

Target

NR3C1 (GR) [HSA:2908] [KO:K05771]

Pathway

hsa04080

Neuroactive ligand-receptor interaction

Interaction

Structure map

map07225

Glucocorticoid and mineralocorticoid receptor agonists/antagonists

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA11 Fluocinonide
      D00325  Fluocinonide (JP18/USP/INN) <JP/US>
D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AC Corticosteroids, potent (group III)
     D07AC08 Fluocinonide
      D00325  Fluocinonide (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Dermatological Agents
  Dermatitis and Pruitus Agents
   Glucocorticoids, High Potency
    Fluocinonide
     D00325  Fluocinonide (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
2  Agents affecting individual organs
  26  Epidermides
   264  Analgesics, anti-itchings, astringents, anti-inflammatory agents
    2646  Adrenocorticotropic hormones
     D00325  Fluocinonide (JP18/USP/INN)
Drug groups [BR:br08330]
Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    D00325  Fluocinonide
Drug classes [BR:br08332]
Anti-inflammatory
  DG01955  Corticosteroid
   D00325  Fluocinonide
Target-based classification of drugs [BR:br08310]
Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D00325  Fluocinonide (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
  D00325  Fluocinonide
Topical steroids potency [br08317.html]
Classification in the USA
  D00325
Classification in Japan
  D00325

Other DBs

CAS:

356-12-7

PubChem:

7847391

ChEBI:

5109

LigandBox:

D00325

NIKKAJI:

J2.036B

KCF data

ATOM        35
            1   C2x C    18.6900  -28.5600
            2   C5x C    18.6900  -29.8900
            3   C2x C    19.8800  -30.5900
            4   C2y C    21.0700  -29.8900
            5   C1z C    21.0700  -28.5600
            6   C2x C    19.8800  -27.8600
            7   C1y C    22.2600  -30.5900
            8   C1x C    23.4500  -29.8900
            9   C1y C    23.4500  -28.5600
            10  C1z C    22.2600  -27.8600
            11  C1y C    24.5700  -27.8600
            12  C1z C    24.5700  -26.5300
            13  C1x C    23.4500  -25.8300
            14  C1y C    22.2600  -26.5300
            15  C1x C    26.9500  -27.8600
            16  C1y C    26.9500  -26.5300
            17  C1z C    25.7600  -25.8300
            18  O5x O    17.5700  -30.5900
            19  C1a C    21.0700  -27.1600
            20  X   F    22.2600  -29.1900
            21  O1a O    21.0700  -25.8300
            22  C1a C    24.5700  -25.1300
            23  C5a C    25.7600  -24.2200
            24  O2x O    27.1600  -24.9200
            25  O5a O    26.9500  -23.5200
            26  C1b C    24.5700  -23.5200
            27  O7a O    23.4500  -24.2200
            28  O2x O    28.3500  -26.5300
            29  C1z C    28.5600  -24.9200
            30  C1a C    29.9600  -24.9200
            31  C1a C    28.5600  -23.5200
            32  X   F    22.2600  -31.9900
            33  C7a C    22.2138  -23.5629
            34  C1a C    20.9972  -24.3229
            35  O6a O    22.1654  -22.1902
BOND        39
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21    2  18 2
            22    5  19 1 #Up
            23   10  20 1 #Down
            24   14  21 1 #Up
            25   12  22 1 #Up
            26   17  23 1 #Up
            27   17  24 1 #Down
            28   23  25 2
            29   23  26 1
            30   26  27 1
            31   16  28 1 #Down
            32   24  29 1
            33   29  28 1
            34   29  30 1
            35   29  31 1
            36    7  32 1 #Down
            37   27  33 1
            38   33  34 1
            39   33  35 2