Flurandrenolide


Entry
D00328                      Drug                                   
Name
Flurandrenolide (USP);
Fludroxycortide (JAN/INN);
Cordran (TN)
Product
CORDRAN (Almirall), CORDRAN (Almirall), CORDRAN (Almirall), FLURANDRENOLIDE (Taro Pharmaceuticals U.S.A.), FLURANDRENOLIDE (Taro Pharmaceuticals U.S.A.)
  Generic
FLURANDRENOLIDE (Bryant Ranch Prepack), FLURANDRENOLIDE (Padagis Israel Pharmaceuticals), FLURANDRENOLIDE (Teligent Pharma)
Formula
C24H33FO6
Exact mass
436.2261
Mol weight
436.5136
Structure
Simcomp
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Remark
Therapeutic category: 2646
ATC code: D07AC07
Product: D00328<JP/US>
Efficacy
Anti-inflammatory, Antipruritic, Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AC Corticosteroids, potent (group III)
     D07AC07 Fludroxycortide
      D00328  Flurandrenolide (USP) <JP/US>
USP drug classification [BR:br08302]
 Dermatological Agents
  Dermatitis and Pruitus Agents
   Glucocorticoids, Medium Potency
    Flurandrenolide
     D00328  Flurandrenolide (USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  26  Epidermides
   264  Analgesics, anti-itchings, astringents, anti-inflammatory agents
    2646  Adrenocorticotropic hormones
     D00328  Flurandrenolide (USP); Fludroxycortide (JAN/INN)
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    D00328  Flurandrenolide
Drug classes [BR:br08332]
 Anti-inflammatory
  DG01955  Corticosteroid
   D00328  Flurandrenolide
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D00328  Flurandrenolide (USP) <JP/US>
Topical steroids potency [br08317.html]
 Classification in the USA
  D00328
Other DBs
CAS: 1524-88-5
PubChem: 7847394
ChEBI: 5127
LigandBox: D00328
NIKKAJI: J3.671D
KCF data

ATOM        31
            1   C1z C    22.9890  -17.6284
            2   C1z C    21.7992  -18.2991
            3   C1y C    24.1674  -18.3284
            4   O2x O    24.3950  -16.9284
            5   C5a C    23.0007  -16.2518
            6   C1y C    21.7816  -19.6641
            7   C1x C    20.6091  -17.5991
            8   C1a C    21.7583  -16.8525
            9   C1x C    24.1500  -19.6934
            10  O2x O    25.6608  -18.3167
            11  C1z C    25.7190  -16.9225
            12  C1b C    21.8225  -15.5518
            13  O5a O    24.2082  -15.5809
            14  C1y C    20.5974  -20.3408
            15  C1y C    19.4192  -18.2758
            16  C1a C    25.6549  -15.7384
            17  C1a C    27.0432  -16.9225
            18  O1a O    21.8399  -14.1809
            19  C1y C    19.4133  -19.6467
            20  C1x C    20.5974  -21.7117
            21  O1a O    18.2408  -17.5758
            22  C1z C    18.2175  -20.3291
            23  C1y C    19.3959  -22.4000
            24  C2y C    18.2117  -21.7000
            25  C1x C    17.0276  -19.6467
            26  C1a C    18.2117  -19.0808
            27  X   F    19.3901  -23.7707
            28  C2x C    17.0276  -22.3941
            29  C1x C    15.8377  -20.3291
            30  C5x C    15.8377  -21.7000
            31  O5x O    14.6476  -22.3941
BOND        35
            1     1   2 1
            2     1   3 1
            3     1   4 1 #Down
            4     1   5 1 #Up
            5     2   6 1
            6     2   7 1
            7     2   8 1 #Up
            8     3   9 1
            9     3  10 1 #Down
            10    4  11 1
            11    5  12 1
            12    5  13 2
            13    6  14 1
            14    7  15 1
            15   11  16 1
            16   11  17 1
            17   12  18 1
            18   14  19 1
            19   14  20 1
            20   15  21 1 #Up
            21   19  22 1
            22   20  23 1
            23   22  24 1
            24   22  25 1
            25   22  26 1 #Up
            26   23  27 1 #Down
            27   24  28 2
            28   25  29 1
            29   28  30 1
            30   30  31 2
            31    6   9 1
            32   10  11 1
            33   15  19 1
            34   23  24 1
            35   29  30 1