Entry

D00346                      Drug

Name

Isoniazid (JP18/USP/INN);
Laniazid (TN)

Product

Generic

ISONIAZID (A-S Medication Solutions), ISONIAZID (A-S Medication Solutions), ISONIAZID (A-S Medication Solutions), ISONIAZID (American Health Packaging), ISONIAZID (Aphena Pharma Solutions - Tennessee), ISONIAZID (Aphena Pharma Solutions - Tennessee), ISONIAZID (Bryant Ranch Prepack), ISONIAZID (CMP Pharma), ISONIAZID (Lannett Company), ISONIAZID (Mylan Institutional), ISONIAZID (PD-Rx Pharmaceuticals), ISONIAZID (Preferred Pharmaceuticals), ISONIAZID (Proficient Rx LP), ISONIAZID (REMEDYREPACK), ISONIAZID (REMEDYREPACK), ISONIAZID (RPK Pharmaceuticals), ISONIAZID (Sandoz), ISONIAZID (Teva Pharmaceuticals USA)

Formula

C6H7N3O

Exact mass

137.0589

Mol weight

137.1393

Structure

Simcomp

Class

Antibacterial
DG01966  Antitubercular
Neuropsychiatric agent
DG01568  MAO inhibitor
  DG01519  Non-selective monoamine oxidase inhibitor

Remark

Same as:

C07054

Therapeutic category:

6222

ATC code:

J04AC01

Chemical structure group:

DG00642

Product (DG00642):

D00346<JP/US> D02002<JP>

Efficacy

Antibacterial (tuberculostatic)

Disease

Tuberculosis [DS:H00342]

Comment

Hydrazide

Target

enoyl-[acyl-carrier-protein] reductase (NADH) [KO:K11611]

Interaction

Structure map

map07216

Catecholamine transferase inhibitors

Other map

map00983

Drug metabolism - other enzymes

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
J ANTIINFECTIVES FOR SYSTEMIC USE
  J04 ANTIMYCOBACTERIALS
   J04A DRUGS FOR TREATMENT OF TUBERCULOSIS
    J04AC Hydrazides
     J04AC01 Isoniazid
      D00346  Isoniazid (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Antimycobacterials
  Antituberculars
   Isoniazid
    D00346  Isoniazid (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   622  Tuberculosis preparations
    6222  Isoniazids
     D00346  Isoniazid (JP18/USP/INN)
Drug groups [BR:br08330]
Antibacterial
  DG01966  Antitubercular
   DG00642  Isoniazid
    D00346  Isoniazid
Neuropsychiatric agent
  DG01568  MAO inhibitor
   DG01519  Non-selective monoamine oxidase inhibitor
    DG00642  Isoniazid
     D00346  Isoniazid
Antimicrobials [BR:br08307]
Antibacterials
  Other antibacterials
   Mycolic acid biosynthesis inhibitor
    D00346  Isoniazid (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
  D00346  Isoniazid
  D00346  Isoniazid tablets
  D00346  Isoniazid injection
Drug groups [BR:br08330]
Antibacterial
  DG01966  Antitubercular
   DG00642  Isoniazid
Neuropsychiatric agent
  DG01568  MAO inhibitor
   DG01519  Non-selective monoamine oxidase inhibitor
    DG00642  Isoniazid
Antimicrobials abbreviations [BR:br08327]
Antibacterials
  Other antibacterials
   Mycolic acid biosynthesis inhibitor
    DG00642  Isoniazid

Other DBs

CAS:

54-85-3

PubChem:

7847412

ChEBI:

6030

PDB-CCD:

NIZ[PDBj]

LigandBox:

D00346

NIKKAJI:

J1.371D

KCF data

ATOM        10
            1   C8y C    22.4877  -16.7300
            2   C5a C    23.6995  -17.4291
            3   C8x C    21.2816  -17.4291
            4   C8x C    22.4877  -15.3316
            5   N1b N    24.9115  -16.7300
            6   O5a O    23.6995  -18.8275
            7   C8x C    20.0638  -16.7300
            8   C8x C    21.2816  -14.6266
            9   N1a N    26.1293  -17.4291
            10  N5x N    20.0638  -15.3316
BOND        10
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     2   6 2
            6     3   7 1
            7     4   8 2
            8     5   9 1
            9     7  10 2
            10    8  10 1