Entry

D00353                      Drug

Name

Lamivudine (JAN/USP/INN);
Epivir (TN)

Abbr

3TC

Product

EPIVIR (GlaxoSmithKline LLC), EPIVIR (ViiV Healthcare Company)

Generic

LAMIVUDINE (American Health Packaging), LAMIVUDINE (Apotex Corp.), LAMIVUDINE (Apotex Corp.), LAMIVUDINE (Aurobindo Pharma Limited), LAMIVUDINE (Aurobindo Pharma Limited), LAMIVUDINE (Camber Pharmaceuticals), LAMIVUDINE (Camber Pharmaceuticals), LAMIVUDINE (Camber Pharmaceuticals), LAMIVUDINE (Cipla USA), LAMIVUDINE (Golden State Medical Supply), LAMIVUDINE (Ingenus Pharmaceuticals), LAMIVUDINE (Lannett Company), LAMIVUDINE (Lupin Pharmaceuticals), LAMIVUDINE (Macleods Pharmaceuticals Limited), LAMIVUDINE (Major Pharmaceuticals), LAMIVUDINE (Prasco Laboratories), LAMIVUDINE (Rising Health), LAMIVUDINE (Strides Pharma Science Limited)

Formula

C8H11N3O3S

Exact mass

229.0521

Mol weight

229.2562

Structure

Simcomp

Class

Antiviral
DG01890  Nucleoside reverse transcriptase inhibitor (NRTI)
DG03107  Anti-HIV agent
  DG01656  HIV reverse transcriptase inhibitor
Transporter substrate
DG02859  SLC22A6 substrate

Remark

Same as:

C07065

Therapeutic category:

6250

ATC code:

J05AF05

Product:

D00353<JP/US>

Product (mixture):

D07507<JP/US> D08775<JP/US> D10600<JP/US> D10838<US> D11392<US> D11395<US> D11396<US> D11522<JP/US>

Efficacy

Antiviral, Reverse transcriptase inhibitor

Disease

HIV-1 infection [DS:H01563]
Hepatitis B [DS:H00412]

Target

HBV reverse transcriptase [KO:K21037]
HIV-1 reverse transcriptase [KO:K24802]

Pathway

ko03230

Viral genome structure

ko03240

Viral replication

ko03250

Viral life cycle - HIV-1

ko05161

Hepatitis B

Metabolism

Transporter: SLC22A6 [HSA:9356]

Interaction

Structure map

map07044

Antiviral agents

map07053

Anti-HIV agents

Other map

map04976

Bile secretion

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
J ANTIINFECTIVES FOR SYSTEMIC USE
  J05 ANTIVIRALS FOR SYSTEMIC USE
   J05A DIRECT ACTING ANTIVIRALS
    J05AF Nucleoside and nucleotide reverse transcriptase inhibitors
     J05AF05 Lamivudine
      D00353  Lamivudine (JAN/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Antivirals
  Anti-hepatitis B (HBV) Agents
   Lamivudine
    D00353  Lamivudine (JAN/USP/INN)
  Anti-HIV Agents, Nucleoside and Nucleotide Reverse Transcriptase Inhibitors (NRTI)
   Lamivudine
    D00353  Lamivudine (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   625  Antivirals
    6250  Antivirals
     D00353  Lamivudine (JAN/USP/INN)
Drug groups [BR:br08330]
Antiviral
  DG01890  Nucleoside reverse transcriptase inhibitor (NRTI)
   D00353  Lamivudine
  DG03107  Anti-HIV agent
   DG01656  HIV reverse transcriptase inhibitor
    D00353  Lamivudine
Transporter substrate
  DG02859  SLC22A6 substrate
   D00353  Lamivudine
Drug classes [BR:br08332]
Antiviral
  DG03107  Anti-HIV agent
   D00353  Lamivudine
Antimicrobials [BR:br08307]
Antivirals
  Genome replication inhibitor
   HBV reverse transcriptase inhibitor
    D00353  Lamivudine (JAN/USP/INN) <JP/US>
Antimicrobials abbreviations [BR:br08327]
Antivirals
  Genome replication inhibitor
   HBV reverse transcriptase inhibitor
    D00353  Lamivudine (JAN/USP/INN)
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
  D00353
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
  D00353
Drug metabolizing enzymes and transporters [br08309.html]
Drug transporters
  D00353

Other DBs

CAS:	134678-17-4

PubChem:

7847419

ChEBI:

63577

PDB-CCD:

3TC[PDBj]

LigandBox:

D00353

NIKKAJI:

J457.051K

KCF data

ATOM        15
            1   C1y C    19.1100  -17.9200
            2   O2x O    17.9900  -17.0800
            3   C1x C    18.6900  -19.2500
            4   C1y C    16.8700  -17.9200
            5   S2x S    17.2900  -19.2500
            6   C1b C    15.6800  -17.2900
            7   O1a O    14.3500  -18.1300
            8   C8x C    20.3000  -15.8200
            9   N4y N    20.3000  -17.2200
            10  C8y C    21.4900  -17.9200
            11  N5x N    22.7500  -17.2200
            12  C8y C    22.7500  -15.8200
            13  C8x C    21.4900  -15.1200
            14  O5x O    21.4900  -19.3200
            15  N1a N    23.9400  -15.1200
BOND        16
            1     1   2 1
            2     1   3 1
            3     2   4 1
            4     3   5 1
            5     4   6 1 #Down
            6     6   7 1
            7     4   5 1
            8     8   9 1
            9     9  10 1
            10   10  11 1
            11   11  12 2
            12   12  13 1
            13    8  13 2
            14    1   9 1 #Down
            15   10  14 2
            16   12  15 1