| Entry |
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| Name | Lamotrigine (JAN/USP/INN); Lamictal (TN) | ||||||||||
| Product | LAMICTAL (GlaxoSmithKline LLC), LAMICTAL (GlaxoSmithKline LLC) | ||||||||||
| Generic | LAMOTRIGINE (Cadila Healthcare Limited), LAMOTRIGINE (A-S Medication Solutions), LAMOTRIGINE (A-S Medication Solutions), LAMOTRIGINE (A-S Medication Solutions), LAMOTRIGINE (A-S Medication Solutions), LAMOTRIGINE (A-S Medication Solutions), LAMOTRIGINE (A-S Medication Solutions), LAMOTRIGINE (A-S Medication Solutions), LAMOTRIGINE (Actavis Pharma), LAMOTRIGINE (Advagen Pharma Limited), LAMOTRIGINE (Ajanta Pharma USA), LAMOTRIGINE (Alembic Pharmaceuticals), LAMOTRIGINE (Alembic Pharmaceuticals), LAMOTRIGINE (Alembic Pharmaceuticals Limited), LAMOTRIGINE (American Health Packaging), LAMOTRIGINE (Amneal Pharmaceuticals LLC), LAMOTRIGINE (Amneal Pharmaceuticals of New York LLC), LAMOTRIGINE (Amneal Pharmaceuticals of New York LLC), LAMOTRIGINE (Amring Pharmaceuticals), LAMOTRIGINE (Ascend Laboratories), LAMOTRIGINE (Asclemed USA), LAMOTRIGINE (Aurobindo Pharma Limited), LAMOTRIGINE (Aurobindo Pharma Limited), LAMOTRIGINE (AvKARE), LAMOTRIGINE (AvKARE), LAMOTRIGINE (Bryant Ranch Prepack), LAMOTRIGINE (Bryant Ranch Prepack), LAMOTRIGINE (Bryant Ranch Prepack), LAMOTRIGINE (Bryant Ranch Prepack), LAMOTRIGINE (Bryant Ranch Prepack), LAMOTRIGINE (Bryant Ranch Prepack), LAMOTRIGINE (Bryant Ranch Prepack), LAMOTRIGINE (Bryant Ranch Prepack), LAMOTRIGINE (Bryant Ranch Prepack), LAMOTRIGINE (Bryant Ranch Prepack), LAMOTRIGINE (Bryant Ranch Prepack), LAMOTRIGINE (Bryant Ranch Prepack), LAMOTRIGINE (Cadila Healthcare Limited), LAMOTRIGINE (Cardinal Health), LAMOTRIGINE (Cardinal Health 107), LAMOTRIGINE (Cipla USA), LAMOTRIGINE (Clinical Solutions Wholesale), LAMOTRIGINE (Clinical Solutions Wholesale), LAMOTRIGINE (DIRECT RX), LAMOTRIGINE (DIRECT RX), LAMOTRIGINE (Denton Pharma), LAMOTRIGINE (DirectRX), LAMOTRIGINE (Dr. Reddy's Laboratories), LAMOTRIGINE (Dr.Reddy's Laboratories Limited), LAMOTRIGINE (Dr.Reddy's Laboratories Limited), LAMOTRIGINE (Dr.Reddy's Laboratories Limited), LAMOTRIGINE (Glenmark Pharmaceuticals), LAMOTRIGINE (Golden State Medical Supply), LAMOTRIGINE (JUBILANT CADISTA PHARMACEUTICALS), LAMOTRIGINE (Lake Erie Medical DBA Quality Care Products LLC), LAMOTRIGINE (Lake Erie Medical DBA Quality Care Products LLC), LAMOTRIGINE (Major Pharmaceuticals), LAMOTRIGINE (NCS HealthCare of KY), LAMOTRIGINE (NorthStar Rx LLC), LAMOTRIGINE (NorthStar Rx LLC), LAMOTRIGINE (Northstar Rx LLC.), LAMOTRIGINE (NuCare Pharmaceuticals), LAMOTRIGINE (NuCare Pharmaceuticals), LAMOTRIGINE (OWP Pharmaceuticals), SUBVENITE (OWP Pharmaceuticals), LAMOTRIGINE (PD-Rx Pharmaceuticals), LAMOTRIGINE (PD-Rx Pharmaceuticals), LAMOTRIGINE (PD-Rx Pharmaceuticals), LAMOTRIGINE (Par Pharmaceutical), LAMOTRIGINE (Preferred Pharmaceuticals), LAMOTRIGINE (Preferred Pharmaceuticals), LAMOTRIGINE (Preferred Pharmaceuticals), LAMOTRIGINE (Preferred Pharmaceuticals), LAMOTRIGINE (Preferred Pharmaceuticals), LAMOTRIGINE (Preferred Pharmaceuticals), LAMOTRIGINE (Proficient Rx LP), LAMOTRIGINE (Proficient Rx LP), LAMOTRIGINE (Proficient Rx LP), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), SUBVENITE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (RPK Pharmaceuticals), LAMOTRIGINE (RPK Pharmaceuticals), LAMOTRIGINE (RPK Pharmaceuticals), LAMOTRIGINE (Rising Pharma Holdings), LAMOTRIGINE (ST. MARY'S MEDICAL PARK PHARMACY), LAMOTRIGINE (ScieGen Pharmaceuticals), LAMOTRIGINE (St. Mary's Medical Park Pharmacy), LAMOTRIGINE (St. Mary's Medical Park Pharmacy), LAMOTRIGINE (St. Mary's Medical Park Pharmacy), LAMOTRIGINE (Taro Pharmaceuticals U.S.A.), LAMOTRIGINE (Taro Pharmaceuticals U.S.A.), LAMOTRIGINE (Torrent Pharmaceuticals Limited), LAMOTRIGINE (Torrent Pharmaceuticals Limited), LAMOTRIGINE (Unichem Pharmaceuticals (USA)), LAMOTRIGINE (Wockhardt USA LLC.), LAMOTRIGINE (Zydus Pharmaceuticals (USA)), LAMOTRIGINE (Zydus Pharmaceuticals USA), LAMOTRIGINE (Alembic Pharmaceuticals Limited), LAMOTRIGINE EXTENDED RELEASE (Bryant Ranch Prepack), LAMOTRIGINE EXTENDED RELEASE (Par Pharmaceutical), LAMOTRIGINE EXTENDED RELEASE (TruPharma), LAMOTRIGINE (Yiling Pharmaceutical) | ||||||||||
| Formula | C9H7Cl2N5 | ||||||||||
| Exact mass | 255.0079 | ||||||||||
| Mol weight | 256.0914 | ||||||||||
| Structure |  | ||||||||||
| Class | Neuropsychiatric agent DG03199 Antiepileptic agent Metabolizing enzyme substrate DG02924 UGT substrate DG03182 UGT1A4 substrate | ||||||||||
| Remark |
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| Efficacy | Anti-bipolar disorder, Anticonvulsant, Antiepileptic | ||||||||||
| Disease | Lennox-Gastaut syndrome [DS:H01813] Bipolar disorder [DS:H01653] | ||||||||||
| Target | SCN1A [HSA:6323] [KO:K04833] SCN2A [HSA:6326] [KO:K04834] SCN3A [HSA:6328] [KO:K04836] SCN4A [HSA:6329] [KO:K04837] SCN5A [HSA:6331] [KO:K04838] SCN8A [HSA:6334] [KO:K04840] SCN9A [HSA:6335] [KO:K04841] SCN10A [HSA:6336] [KO:K04842] SCN11A [HSA:11280] [KO:K04843] | ||||||||||
| Pathway |
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| Metabolism | Enzyme: UGT1A4 [HSA:54657] | ||||||||||
| Interaction | |||||||||||
| Structure map |
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| Brite | Anatomical Therapeutic Chemical (ATC) classification [BR:br08303] N NERVOUS SYSTEM N03 ANTIEPILEPTICS N03A ANTIEPILEPTICS N03AX Other antiepileptics N03AX09 Lamotrigine D00354 Lamotrigine (JAN/USP/INN) <JP/US> USP drug classification [BR:br08302] Anticonvulsants Anticonvulsants, Other Lamotrigine D00354 Lamotrigine (JAN/USP/INN) Bipolar Agents Mood Stabilizers Lamotrigine D00354 Lamotrigine (JAN/USP/INN) Therapeutic category of drugs in Japan [BR:br08301] 1 Agents affecting nervous system and sensory organs 11 Agents affecting central nervous system 113 Antiepileptics 1139 Others D00354 Lamotrigine (JAN/USP/INN) 117 Psychotropics 1179 Others D00354 Lamotrigine (JAN/USP/INN) Drug groups [BR:br08330] Neuropsychiatric agent DG03199 Antiepileptic agent D00354 Lamotrigine Metabolizing enzyme substrate DG02924 UGT substrate DG03182 UGT1A4 substrate D00354 Lamotrigine Target-based classification of drugs [BR:br08310] Ion channels Voltage-gated ion channels Sodium channels SCN1A D00354 Lamotrigine (JAN/USP/INN) <JP/US> SCN2A D00354 Lamotrigine (JAN/USP/INN) <JP/US> SCN3A D00354 Lamotrigine (JAN/USP/INN) <JP/US> SCN4A D00354 Lamotrigine (JAN/USP/INN) <JP/US> SCN5A D00354 Lamotrigine (JAN/USP/INN) <JP/US> SCN8A D00354 Lamotrigine (JAN/USP/INN) <JP/US> SCN9A D00354 Lamotrigine (JAN/USP/INN) <JP/US> SCN10A D00354 Lamotrigine (JAN/USP/INN) <JP/US> SCN11A D00354 Lamotrigine (JAN/USP/INN) <JP/US> New drug approvals in Japan [br08318.html] Drugs with new active ingredients D00354 Drug metabolizing enzymes and transporters [br08309.html] Drug metabolizing enzymes D00354 | ||||||||||
| Other DBs |
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| KCF data | ATOM 16 1 C8y C 21.7344 -17.9428 2 C8y C 20.5227 -17.2321 3 C8y C 21.7285 -19.3408 4 N5x N 22.9459 -17.2378 5 C8y C 20.5286 -15.8341 6 C8x C 19.3053 -17.9311 7 N5x N 22.9343 -20.0398 8 N1a N 20.5111 -20.0281 9 N5x N 24.1576 -17.9485 10 C8y C 19.3169 -15.1350 11 X Cl 21.7461 -15.1467 12 C8x C 18.0995 -17.2262 13 C8y C 24.1517 -19.3465 14 C8x C 18.0995 -15.8281 15 X Cl 19.3228 -13.7313 16 N1a N 25.3633 -20.0513 BOND 17 1 1 2 1 2 1 3 2 3 1 4 1 4 2 5 2 5 2 6 1 6 3 7 1 7 3 8 1 8 4 9 2 9 5 10 1 10 5 11 1 11 6 12 2 12 7 13 2 13 10 14 2 14 10 15 1 15 13 16 1 16 9 13 1 17 12 14 1 |