Entry

D00355                      Drug

Name

Lansoprazole (JP18/USP/INN);
Prevacid (TN)

Product

PREVACID (Cardinal Health), PREVACID (PD-Rx Pharmaceuticals), LANSOPRAZOLE (Takeda Pharmaceuticals America)

Generic

LANSOPRAZOLE (A-S Medication Solutions), LANSOPRAZOLE (A-S Medication Solutions), LANSOPRAZOLE (A-S Medication Solutions), LANSOPRAZOLE (A-S Medication Solutions), LANSOPRAZOLE (Advanced Rx Pharmacy of Tennessee), LANSOPRAZOLE (Advanced Rx Pharmacy of Tennessee), LANSOPRAZOLE (Ajanta Pharma USA), LANSOPRAZOLE (American Health Packaging), LANSOPRAZOLE (Ascend Laboratories), LANSOPRAZOLE (AvKARE), LANSOPRAZOLE (AvKARE), LANSOPRAZOLE (BluePoint Laboratories), LANSOPRAZOLE (Bryant Ranch Prepack), LANSOPRAZOLE (Bryant Ranch Prepack), LANSOPRAZOLE (Bryant Ranch Prepack), LANSOPRAZOLE (Bryant Ranch Prepack), LANSOPRAZOLE (Bryant Ranch Prepack), LANSOPRAZOLE (Bryant Ranch Prepack), LANSOPRAZOLE (Bryant Ranch Prepack), LANSOPRAZOLE (Bryant Ranch Prepack), LANSOPRAZOLE (Bryant Ranch Prepack), LANSOPRAZOLE (Bryant Ranch Prepack), LANSOPRAZOLE (Bryant Ranch Prepack), LANSOPRAZOLE (Bryant Ranch Prepack), LANSOPRAZOLE (Cadila Healthcare Limited), LANSOPRAZOLE (Cadila Healthcare Limited), LANSOPRAZOLE (Camber Pharmaceuticals), LANSOPRAZOLE (Cardinal Health), LANSOPRAZOLE (DIRECT RX), LANSOPRAZOLE (DIRECT RX), LANSOPRAZOLE (Direct RX), LANSOPRAZOLE (DirectRx), LANSOPRAZOLE (Dr.Reddy's Laboratories), LANSOPRAZOLE (Dr.Reddys Laboratories), LANSOPRAZOLE (Golden State Medical Supply), LANSOPRAZOLE (Lannett Company), LANSOPRAZOLE (Lifestar Pharma LLC.), LANSOPRAZOLE (Major Pharmaceuticals), LANSOPRAZOLE (McKesson Corporation dba SKY Packaging), LANSOPRAZOLE (Mylan Institutional), LANSOPRAZOLE (Mylan Pharmaceuticals), LANSOPRAZOLE (Mylan Pharmaceuticals), LANSOPRAZOLE (NorthStar Rx LLC), LANSOPRAZOLE (NuCare Pharmaceuticals), LANSOPRAZOLE (NuCare Pharmaceuticals), LANSOPRAZOLE (NuCare Pharmaceuticals), LANSOPRAZOLE (NuCare Pharmaceuticals), LANSOPRAZOLE (NuCare Pharmaceuticals), LANSOPRAZOLE (Preferred Pharmaceuticals), LANSOPRAZOLE (Preferred Pharmaceuticals), LANSOPRAZOLE (Preferred Pharmaceuticals), LANSOPRAZOLE (Preferred Pharmaceuticals), LANSOPRAZOLE (Proficient Rx LP), LANSOPRAZOLE (Proficient Rx LP), LANSOPRAZOLE (Rising Pharma Holdings), LANSOPRAZOLE (St. Mary's Medical Park Pharmacy), LANSOPRAZOLE (Teva Pharmaceuticals USA), LANSOPRAZOLE (Teva Pharmaceuticals USA), LANSOPRAZOLE (Xiromed LLC), LANSOPRAZOLE (Zydus Pharmaceuticals (USA)), LANSOPRAZOLE (Zydus Pharmaceuticals USA), LANSOPRAZOLE (medsource pharmaceuticals), LANSOPRAZOLE DR (Direct_Rx)

Formula

C16H14F3N3O2S

Exact mass

369.0759

Mol weight

369.3615

Structure

Simcomp

Class

Gastrointestinal agent
DG01975  Agents for peptic ulcer
  DG01646  Proton pump inhibitor (PPI)
Metabolizing enzyme substrate
DG01639  CYP2C19 substrate
DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Metabolizing enzyme inhibitor
DG01933  CYP2C19 inhibitor
Transporter inhibitor
DG02867  ABCC2 inhibitor

Remark

Therapeutic category:

2329

ATC code:

A02BC03

Product:

D00355<JP/US>

Product (mixture):

D08774<US> D10527<JP>

Efficacy

Anti-ulcerative, Proton pump inhibitor

Disease

Duodenal ulcer [DS:H01634]
H. pylori eradication [DS:H00320]
Gastric ulcer [DS:H01634]
Gastroesophageal reflux disease [DS:H01602]
Zollinger-Ellison syndrome [DS:H01522]

Comment

Benzimidazole derivative

Target

ATP4 [HSA:495 496] [KO:K01542 K01543]

Pathway

hsa04966

Collecting duct acid secretion

hsa04971

Gastric acid secretion

Metabolism

Enzyme: CYP2C19 [HSA:1557], CYP3A4 [HSA:1576]

Interaction

CYP inhibition: CYP2C19 [HSA:1557]
Transporter inhibition: ABCC2 [HSA:1244]

Structure map

map07038

Antiulcer drugs

map07233

Ion transporter inhibitors

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
  A02 DRUGS FOR ACID RELATED DISORDERS
   A02B DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
    A02BC Proton pump inhibitors
     A02BC03 Lansoprazole
      D00355  Lansoprazole (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Gastrointestinal Agents
  Proton Pump Inhibitors
   Lansoprazole
    D00355  Lansoprazole (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
2  Agents affecting individual organs
  23  Digestive organ agents
   232  Peptic ulcer agents
    2329  Others
     D00355  Lansoprazole (JP18/USP/INN)
Drug groups [BR:br08330]
Gastrointestinal agent
  DG01975  Agents for peptic ulcer
   DG01646  Proton pump inhibitor (PPI)
    D00355  Lansoprazole
Metabolizing enzyme substrate
  DG01639  CYP2C19 substrate
   D00355  Lansoprazole
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D00355  Lansoprazole
Metabolizing enzyme inhibitor
  DG01933  CYP2C19 inhibitor
   D00355  Lansoprazole
Transporter inhibitor
  DG02867  ABCC2 inhibitor
   D00355  Lansoprazole
Drug classes [BR:br08332]
Gastrointestinal agent
  DG01646  Proton pump inhibitor (PPI)
   D00355  Lansoprazole
Target-based classification of drugs [BR:br08310]
Enzymes
  Hydrolases (EC3)
   ATPase
    ATP4
     D00355  Lansoprazole (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
  D00355  Lansoprazole
  D00355  Lansoprazole delayed-release orally disintegration tablets
  D00355  Lansoprazole delayed-release capsules
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
  D00355
Drug transporters
  D00355
Pharmacogenomic biomarkers [br08341.html]
Polymorphisms and mutations affecting drug response
  D00355
Rx-to-OTC switch list in the USA [br08315.html]
D00355

Other DBs

CAS:	103577-45-3

PubChem:

7847421

ChEBI:

6375

LigandBox:

D00355

NIKKAJI:

J126.212B

KCF data

ATOM        25
            1   C8x C    14.2800  -19.3900
            2   C8x C    14.2800  -20.7900
            3   C8x C    15.4924  -21.4900
            4   C8y C    16.7049  -20.7900
            5   C8y C    16.7049  -19.3900
            6   C8x C    15.4924  -18.6900
            7   N5x N    18.0364  -21.2226
            8   C8y C    18.8593  -20.0900
            9   N4x N    18.0364  -18.9574
            10  S4a S    20.2300  -20.0900
            11  C1b C    20.9300  -21.3024
            12  O3c O    20.9300  -18.8776
            13  C8y C    22.3298  -21.3024
            14  C8y C    23.0203  -22.4980
            15  C8y C    24.4203  -22.4978
            16  C8x C    25.1201  -21.2853
            17  C8x C    24.4297  -20.0898
            18  N5x N    23.0297  -20.0899
            19  C1a C    22.3349  -23.6852
            20  O2a O    25.1110  -23.6932
            21  C1b C    26.5296  -23.6932
            22  C1d C    27.2156  -24.8806
            23  X   F    28.4280  -24.1806
            24  X   F    26.0032  -25.5806
            25  X   F    27.9156  -26.0931
BOND        27
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 2
            9     8   9 1
            10    5   9 1
            11    8  10 1
            12   10  11 1
            13   10  12 2
            14   11  13 1
            15   13  14 2
            16   14  15 1
            17   15  16 2
            18   16  17 1
            19   17  18 2
            20   13  18 1
            21   14  19 1
            22   15  20 1
            23   20  21 1
            24   21  22 1
            25   22  23 1
            26   22  24 1
            27   22  25 1