Entry

D00358                      Drug

Name

Lidocaine (JP18/USP/INN);
Dentipatch (TN);
Xylocaine (TN)

Product

LIDODERM (Endo Pharmaceuticals), ZTLIDO (Scilex Pharmaceuticals)

Generic

LIDOCAINE (A-S Medication Solutions), LIDOCAINE (ATLANTIC BIOLOGICALS CORP.), LIDOCAINE (Actavis Pharma), LIDOCAINE (Actavis Pharma), LIDOCAINE (Alembic Pharmaceuticals), LIDOCAINE (Aleor Dermaceuticals Limited), LIDOCAINE (Amneal Pharmaceuticals LLC), LIDOCAINE (Amneal Pharmaceuticals LLC), LIDOCAINE (Amneal Pharmaceuticals LLC), LIDOCAINE (Asclemed USA), LIDOCAINE (Asclemed USA), LIDOCAINE (Asclemed USA), LIDOCAINE (Asclemed USA), LIDOCAINE (AvKARE), LIDOCAINE (Bryant Ranch Prepack), LIDOCAINE (Bryant Ranch Prepack), LIDOCAINE (Bryant Ranch Prepack), LIDOCAINE (Bryant Ranch Prepack), LIDOCAINE (Bryant Ranch Prepack), LIDOCAINE (Bryant Ranch Prepack), LIDOCAINE (Bryant Ranch Prepack), LIDOCAINE (Bryant Ranch Prepack), LIDOCAINE (Cardinal Health), LIDOCAINE (Cardinal Health), LIDOCAINE (Cipla USA), LIDOCAINE (DIRECT RX), LIDOCAINE (DIRECT RX), LIDOCAINE (DIRECTRX), LIDOCAINE (EXELAN PHARMACEUTICALS), LIDOCAINE (Fougera Pharmaceuticals), LIDOCAINE (GeneYork Pharmaceuticals Group LLC), LIDOCAINE (Glenmark Pharmaceuticals), LIDOCAINE (Golden State Medical Supply), LIDOCAINE (Hi-Tech Pharmacal), LIDOCAINE (IPG PHARMACEUTICALS), LIDOCAINE (IPG Pharmaceuticals), LIDOCAINE (Lake Erie Medical DBA Quality Care Products LLC), LIDOCAINE (Lake Erie Medical DBA Quality Care Products LLC), LIDOCAINE (Lake Erie Medical DBA Quality Care Products LLC), LIDOCAINE (Macleods Pharmaceuticals Limited), LIDOCAINE (Mylan Pharmaceuticals), LIDOCAINE (Northstar Rx LLC), LIDOCAINE (Northstar RxLLC), LIDOCAINE (NuCare Pharmaceuticals), LIDOCAINE (NuCare Pharmaceuticals), LIDOCAINE (NuCare Pharmaceuticals), LIDOCAINE (NuCare Pharmaceuticals), LIDOCAINE (NuCare Pharmaceuticals), LIDOCAINE (Par Pharmaceutical), LIDOCAINE (Preferred Pharmaceuticals), LIDOCAINE (Preferred Pharmaceuticals), LIDOCAINE (Preferred Pharmaceuticals), LIDOCAINE (Preferred Pharmaceuticals), LIDOCAINE (Preferred Pharmaceuticals), LIDOCAINE (Preferred Pharmaceuticals), LIDOCAINE (Proficient Rx LP), LIDOCAINE (Proficient Rx LP), LIDOCAINE (Proficient Rx LP), LIDOCAINE (Proficient Rx LP), LIDOCAINE (Proficient Rx LP), LIDOCAINE (Proficient Rx LP), LIDOCAINE (Proficient Rx LP), LIDOCAINE (Proficient Rx LP), LIDOCAINE (Proficient Rx LP), LIDOCAINE (PureTek Corporation), LIDOCAINE (QUAGEN PHARMACEUTICALS LLC), LIDOCAINE (Quality Care; Products), LIDOCAINE (REMEDYREPACK), LIDOCAINE (REMEDYREPACK), LIDOCAINE (REMEDYREPACK), LIDOCAINE (Septodont), LIDOCAINE (St. Mary's Medical Park Pharmacy), LIDOCAINE (St. Mary's Medical Park Pharmacy), LIDOCAINE (St. Mary's Medical Park Pharmacy), LIDOCAINE (Strides Pharma Science Limited), LIDOCAINE (Taro Pharmaceuticals U.S.A.), LIDOCAINE (Taro Pharmaceuticals U.S.A.), LIDOCAINE (Teligent Pharma), LIDOCAINE (Unit Dose Services), LIDOCAINE (Unit Dose Services), LMR PLUS (V2 Pharma), LIDOCAINE (VITRUVIAS THERAPEUTICS), LIDOCAINE (medsource pharmaceuticals), LIDOCAINE (medsource pharmaceuticals), LIDOCAINE (medsource pharmaceuticals), LIDOCAINE (medsource pharmaceuticals), LIDOCAINE (medsource pharmaceuticals), LIDOCAINE (medsource pharmaceuticals), LIDOCAINE 5% (Bryant Ranch Prepack), LIDOVIX L (Primary Pharmaceuticals), LIDOCAINE 5% (Rhodes Pharmaceuticals L.P.), LIDOCAINE 5% (ATLANTIC BIOLOGICALS CORP.), LIDOCAINE 5% (Preferred Pharmaceuticals), LIDOCAINE 5% (SOLA Pharmaceuticals), DERMALID (Primary Pharmaceuticals)

Formula

C14H22N2O

Exact mass

234.1732

Mol weight

234.3373

Structure

Simcomp

Class

Cardiovascular agent
DG01653  Antiarrhythmics
  DG01652  Class I antiarrhythmic agent
   DG01651  Class Ib antiarrhythmic agent
Neuropsychiatric agent
DG02030  Anesthetics
  DG01675  Local anesthetic
   DG01673  Amide type local anesthetic
Metabolizing enzyme substrate
DG01892  CYP1A2 substrate
DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate

Remark

Same as:

C07073

Therapeutic category:

1214

ATC code:

C01BB01 C05AD01 D04AB01 N01BB02 R02AD02 S01HA07 S02DA01

Chemical structure group:

DG00196

Product (DG00196):

D00358<JP/US> D02086<JP/US> D08127<JP/US>

Product (mixture):

D02740<JP/US> D04688<JP> D04692<JP> D04881<JP> D07742<JP> D11553<US>

Efficacy

Anesthetic (topical), Antiarrhythmic, Sodium channel blocker

Comment

Anilide derivative

Target

SCN1A [HSA:6323] [KO:K04833]
SCN2A [HSA:6326] [KO:K04834]
SCN3A [HSA:6328] [KO:K04836]
SCN4A [HSA:6329] [KO:K04837]
SCN5A [HSA:6331] [KO:K04838]
SCN8A [HSA:6334] [KO:K04840]
SCN9A [HSA:6335] [KO:K04841]
SCN10A [HSA:6336] [KO:K04842]
SCN11A [HSA:11280] [KO:K04843]

Pathway

hsa04261

Adrenergic signaling in cardiomyocytes

hsa04728

Dopaminergic synapse

Metabolism

Enzyme: CYP1A2 [HSA:1544], CYP3A4 [HSA:1576]

Interaction

Structure map

map07037

Antiarrhythmic drugs

map07231

Sodium channel blocking drugs

Other map

map00982

Drug metabolism - cytochrome P450

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01B ANTIARRHYTHMICS, CLASS I AND III
    C01BB Antiarrhythmics, class Ib
     C01BB01 Lidocaine
      D00358  Lidocaine (JP18/USP/INN) <JP/US>
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AD Local anesthetics
     C05AD01 Lidocaine
      D00358  Lidocaine (JP18/USP/INN) <JP/US>
D DERMATOLOGICALS
  D04 ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
   D04A ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
    D04AB Anesthetics for topical use
     D04AB01 Lidocaine
      D00358  Lidocaine (JP18/USP/INN) <JP/US>
N NERVOUS SYSTEM
  N01 ANESTHETICS
   N01B ANESTHETICS, LOCAL
    N01BB Amides
     N01BB02 Lidocaine
      D00358  Lidocaine (JP18/USP/INN) <JP/US>
R RESPIRATORY SYSTEM
  R02 THROAT PREPARATIONS
   R02A THROAT PREPARATIONS
    R02AD Anesthetics, local
     R02AD02 Lidocaine
      D00358  Lidocaine (JP18/USP/INN) <JP/US>
S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01H LOCAL ANESTHETICS
    S01HA Local anesthetics
     S01HA07 Lidocaine
      D00358  Lidocaine (JP18/USP/INN) <JP/US>
  S02 OTOLOGICALS
   S02D OTHER OTOLOGICALS
    S02DA Analgesics and anesthetics
     S02DA01 Lidocaine
      D00358  Lidocaine (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Anesthetics
  Local Anesthetics
   Lidocaine
    D00358  Lidocaine (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
1  Agents affecting nervous system and sensory organs
  12  Agents affecting peripheral nervous system
   121  Local anesthetics
    1214  Xylidines
     D00358  Lidocaine (JP18/USP/INN)
Classification of Japanese OTC drugs [BR:br08313]
Agents for  urogenital organs and anus
  30 Hemorrhoid drugs for external use
   D00358  Lidocaine (JP18/USP/INN)
Agents for integumentary system
  57 Analgesic, antipruritic, astringent, and anti-inflammatory remedies (incl. gel patches)
   D00358  Lidocaine (JP18/USP/INN)
Risk category of Japanese OTC drugs [BR:br08312]
Second-class OTC drugs
  Inorganic and organic chemicals
   Lidocaine
    D00358  Lidocaine (JP18/USP/INN)
Drug groups [BR:br08330]
Cardiovascular agent
  DG01653  Antiarrhythmics
   DG01652  Class I antiarrhythmic agent
    DG01651  Class Ib antiarrhythmic agent
     DG00196  Lidocaine
      D00358  Lidocaine
Neuropsychiatric agent
  DG02030  Anesthetics
   DG01675  Local anesthetic
    DG01673  Amide type local anesthetic
     DG00196  Lidocaine
      D00358  Lidocaine
Metabolizing enzyme substrate
  DG01892  CYP1A2 substrate
   DG00196  Lidocaine
    D00358  Lidocaine
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00196  Lidocaine
     D00358  Lidocaine
Drug classes [BR:br08332]
Cardiovascular agent
  DG01653  Antiarrhythmics
   D00358  Lidocaine
Target-based classification of drugs [BR:br08310]
Ion channels
  Voltage-gated ion channels
   Sodium channels
    SCN1A
     D00358  Lidocaine (JP18/USP/INN) <JP/US>
    SCN2A
     D00358  Lidocaine (JP18/USP/INN) <JP/US>
    SCN3A
     D00358  Lidocaine (JP18/USP/INN) <JP/US>
    SCN4A
     D00358  Lidocaine (JP18/USP/INN) <JP/US>
    SCN5A
     D00358  Lidocaine (JP18/USP/INN) <JP/US>
    SCN8A
     D00358  Lidocaine (JP18/USP/INN) <JP/US>
    SCN9A
     D00358  Lidocaine (JP18/USP/INN) <JP/US>
    SCN10A
     D00358  Lidocaine (JP18/USP/INN) <JP/US>
    SCN11A
     D00358  Lidocaine (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
  D00358  Lidocaine
  D00358  Lidocaine injection
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
  D00358
Drug groups [BR:br08330]
Cardiovascular agent
  DG01653  Antiarrhythmics
   DG01652  Class I antiarrhythmic agent
    DG01651  Class Ib antiarrhythmic agent
     DG00196  Lidocaine
Neuropsychiatric agent
  DG02030  Anesthetics
   DG01675  Local anesthetic
    DG01673  Amide type local anesthetic
     DG00196  Lidocaine
Metabolizing enzyme substrate
  DG01892  CYP1A2 substrate
   DG00196  Lidocaine
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00196  Lidocaine

Other DBs

CAS:

137-58-6

PubChem:

7847424

ChEBI:

6456

PDB-CCD:

LQZ[PDBj]

LigandBox:

D00358

NIKKAJI:

J5.631F

KCF data

ATOM        17
            1   C8y C    23.2602  -19.0646
            2   N1b N    24.4935  -19.7778
            3   C8y C    22.0325  -19.7836
            4   C8y C    23.2602  -17.6441
            5   C5a C    25.7213  -19.0587
            6   C8x C    20.8049  -19.0646
            7   C1a C    22.0384  -21.1983
            8   C8x C    22.0325  -16.9367
            9   C1a C    24.4818  -16.9367
            10  C1b C    26.9488  -19.7778
            11  O5a O    25.7096  -17.6332
            12  C8x C    20.8049  -17.6441
            13  N1c N    28.1823  -19.0587
            14  C1b C    29.4158  -19.7778
            15  C1b C    28.1823  -17.6441
            16  C1a C    30.6317  -19.0587
            17  C1a C    29.4158  -16.9309
BOND        17
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     3   6 1
            6     3   7 1
            7     4   8 2
            8     4   9 1
            9     5  10 1
            10    5  11 2
            11    6  12 2
            12   10  13 1
            13   13  14 1
            14   13  15 1
            15   14  16 1
            16   15  17 1
            17    8  12 1