Lisinopril


Entry
D00362                      Drug                                   
Name
Lisinopril (USP);
Lisinopril hydrate (JP18);
Lisinopril dihydrate;
Prinivil (TN);
Zestril (TN)
Product
ZESTRIL (Almatica Pharma LLC), QBRELIS (Azurity Pharmaceuticals)
  Generic
LISINOPRIL (A-S Medication Solutions), LISINOPRIL (A-S Medication Solutions), LISINOPRIL (A-S Medication Solutions), LISINOPRIL (A-S Medication Solutions), LISINOPRIL (A-S Medication Solutions), LISINOPRIL (A-S Medication Solutions), LISINOPRIL (A-S Medication Solutions), LISINOPRIL (A-S Medication Solutions), LISINOPRIL (A-S Medication Solutions), LISINOPRIL (A-S Medication Solutions), LISINOPRIL (A-S Medication Solutions), LISINOPRIL (A-S Medication Solutions), LISINOPRIL (A-S Medication Solutions), LISINOPRIL (A-S Medication Solutions), LISINOPRIL (Accord Healthcare), LISINOPRIL (Actavis Pharma), LISINOPRIL (American Health Packaging), LISINOPRIL (American Health Packaging), LISINOPRIL (American Health Packaging), LISINOPRIL (Aphena Pharma Solutions - Tennessee), LISINOPRIL (Aphena Pharma Solutions - Tennessee), LISINOPRIL (Aphena Pharma Solutions - Tennessee), LISINOPRIL (Aphena Pharma Solutions - Tennessee), LISINOPRIL (Aphena Pharma Solutions - Tennessee), LISINOPRIL (Aphena Pharma Solutions - Tennessee), LISINOPRIL (Aphena Pharma Solutions - Tennessee), LISINOPRIL (Aphena Pharma Solutions - Tennessee), LISINOPRIL (Aphena Pharma Solutions - Tennessee), LISINOPRIL (Aphena Pharma Solutions - Tennessee), LISINOPRIL (Aphena Pharma Solutions - Tennessee), LISINOPRIL (Aphena Pharma Solutions - Tennessee), LISINOPRIL (Aphena Pharma Solutions - Tennessee), LISINOPRIL (Aurobindo Pharma Limited), LISINOPRIL (BluePoint Laboratories), LISINOPRIL (Bryant Ranch Prepack), LISINOPRIL (Bryant Ranch Prepack), LISINOPRIL (Bryant Ranch Prepack), LISINOPRIL (Bryant Ranch Prepack), LISINOPRIL (Bryant Ranch Prepack), LISINOPRIL (Bryant Ranch Prepack), LISINOPRIL (Bryant Ranch Prepack), LISINOPRIL (Bryant Ranch Prepack), LISINOPRIL (Bryant Ranch Prepack), LISINOPRIL (Bryant Ranch Prepack), LISINOPRIL (Bryant Ranch Prepack), LISINOPRIL (Bryant Ranch Prepack), LISINOPRIL (Bryant Ranch Prepack), LISINOPRIL (Bryant Ranch Prepack), LISINOPRIL (Bryant Ranch Prepack), LISINOPRIL (Bryant Ranch Prepack), LISINOPRIL (Camber Pharmaceuticals), LISINOPRIL (Cambridge Therapeutics Technologies), LISINOPRIL (Cardinal Health), LISINOPRIL (Cardinal Health), LISINOPRIL (Cardinal Health), LISINOPRIL (Cardinal Health), LISINOPRIL (Clinical Solutions Wholesale), LISINOPRIL (Contract Pharmacy Services-PA), LISINOPRIL (DIRECT RX), LISINOPRIL (DIRECT RX), LISINOPRIL (DIRECT RX), LISINOPRIL (Denton Pharma), LISINOPRIL (Denton Pharma), LISINOPRIL (Denton Pharma), LISINOPRIL (Denton Pharma), LISINOPRIL (Denton Pharma), LISINOPRIL (Direct_Rx), LISINORIL (Direct_Rx), LISINOPRIL (Direct_Rx), LISINORIL (Direct_Rx), LISINOPRIL (Direct_Rx), LISINOPRIL (Direct_Rx), LISINOPRIL (Direct_Rx), LISINOPRIL (Exelan Pharmaceuticals), LISINOPRIL (International Laboratories), LISINOPRIL (Lake Erie Medical DBA Quality Care Products LLC), LISINOPRIL (Lake Erie Medical DBA Quality Care Products LLC), LISINOPRIL (Lake Erie Medical DBA Quality Care Products LLC), LISINOPRIL (Legacy Pharmaceutical Packaging), LISINOPRIL (Legacy Pharmaceutical Packaging), LISINOPRIL (Legacy Pharmaceutical Packaging), LISINOPRIL (Lupin Pharmaceuticals), LISINOPRIL (Major Pharmaceuticals), LISINOPRIL (NCS HealthCare of KY), LISINOPRIL (NCS HealthCare of KY), LISINOPRIL (Northwind Pharmaceuticals), LISINOPRIL (Northwind Pharmaceuticals), LISINOPRIL (Northwind Pharmaceuticals), LISINOPRIL (Northwind Pharmaceuticals), LISINOPRIL (Northwind Pharmaceuticals), LISINOPRIL (Northwind Pharmaceuticals), LISINOPRIL (NuCare Pharmaceuticals), LISINOPRIL (NuCare Pharmaceuticals), LISINOPRIL (NuCare Pharmaceuticals), LISINOPRIL (NuCare Pharmaceuticals), LISINOPRIL (NuCare Pharmaceuticals), LISINOPRIL (NuCare Pharmaceuticals), LISINOPRIL (NuCare Pharmaceuticals), LISINOPRIL (NuCare Pharmaceuticals), LISINOPRIL (NuCare Pharmaceuticals), LISINOPRIL (NuCare Pharmaceuticals), LISINOPRIL (NuCare Pharmaceuticals), LISINOPRIL (NuCare Pharmaceuticals), LISINOPRIL (NuCare Pharmaceuticals), LISINOPRIL (NuCare Pharmaceuticals), LISINOPRIL (NuCare Pharmaceuticals), LISINOPRIL (NuCare Pharmaceuticals), LISINOPRIL (NuCare Pharmaceuticals), LISINOPRIL (NuCare Pharmaceuticals), LISINOPRIL (NuCare Pharmaceuticals), LISINOPRIL (NuCare Pharmaceuticals), LISINOPRIL (NuCare Pharmaceuticals), LISINOPRIL (NuCare Pharmaceuticals), LISINOPRIL (NuCare Pharmaceuticals), LISINOPRIL (PD-Rx Pharmaceuticals), LISINOPRIL (PD-Rx Pharmaceuticals), LISINOPRIL (PD-Rx Pharmaceuticals), LISINOPRIL (PD-Rx Pharmaceuticals), LISINOPRIL (PD-Rx Pharmaceuticals), LISINOPRIL (PD-Rx Pharmaceuticals), LISINOPRIL (PD-Rx Pharmaceuticals), LISINOPRIL (PD-Rx Pharmaceuticals), LISINOPRIL (PD-Rx Pharmaceuticals), LISINOPRIL (Preferred Pharmaceuticals), LISINOPRIL (Preferred Pharmaceuticals), LISINOPRIL (Preferred Pharmaceuticals), LISINOPRIL (Preferred Pharmaceuticals), LISINOPRIL (Preferred Pharmaceuticals), LISINOPRIL (Preferred Pharmaceuticals), LISINOPRIL (Preferred Pharmaceuticals), LISINOPRIL (Preferred Pharmaceuticals), LISINOPRIL (Preferred Pharmaceuticlals), LISINOPRIL (Proficient Rx LP), LISINOPRIL (Proficient Rx LP), LISINOPRIL (Proficient Rx LP), LISINOPRIL (Proficient Rx LP), LISINOPRIL (Proficient Rx LP), LISINOPRIL (Proficient Rx LP), LISINOPRIL (Proficient Rx LP), LISINOPRIL (Proficient Rx LP), LISINOPRIL (Proficient Rx LP), LISINOPRIL (Proficient Rx LP), LISINOPRIL (Proficient Rx LP), LISINOPRIL (Proficient Rx LP), LISINOPRIL (Proficient Rx LP), LISINOPRIL (QPharma), LISINOPRIL (QPharma), LISINOPRIL (QPharma), LISINOPRIL (QPharma), LISINOPRIL (QPharma), LISINOPRIL (REMEDYREPACK), LISINOPRIL (REMEDYREPACK), LISINOPRIL (REMEDYREPACK), LISINOPRIL (REMEDYREPACK), LISINOPRIL (REMEDYREPACK), LISINOPRIL (REMEDYREPACK), LISINOPRIL (REMEDYREPACK), LISINOPRIL (REMEDYREPACK), LISINOPRIL (REMEDYREPACK), LISINOPRIL (REMEDYREPACK), LISINOPRIL (REMEDYREPACK), LISINOPRIL (REMEDYREPACK), LISINOPRIL (REMEDYREPACK), LISINOPRIL (RPK Pharmaceuticals), LISINOPRIL (RedPharm Drug), LISINOPRIL (RedPharm Drug), LISINOPRIL (RedPharm Drug), LISINOPRIL (Rising Pharma Holdings), LISINOPRIL (Solco healthcare U.S.), LISINOPRIL (Solco healthcare U.S.), LISINOPRIL (St Mary's Medical Park Pharmacy), LISINOPRIL (St. Mary's Medical Park Pharmacy), LISINOPRIL (St. Mary's Medical Park Pharmacy), LISINOPRIL (St. Mary's Medical Park Pharmacy), LISINOPRIL (St. Mary's Medical Park Pharmacy), LISINOPRIL (St. Mary's Medical Park Pharmacy), LISINOPRIL (St. Mary's Medical Park Pharmacy), LISINOPRIL (St. Mary's Medical Park Pharmacy), LISINOPRIL (Unit Dose Services), LISINOPRIL (Wockhardt USA LLC.), LISINOPRIL (XLCare Pharmaceuticals), LISINOPRIL (Yiling Pharmaceutical)
Formula
C21H31N3O5. 2H2O
Exact mass
441.2475
Mol weight
441.5185
Structure
Simcomp
Class
Cardiovascular agent
 DG01925  Renin-angiotensin system inhibitor
  DG01501  Angiotensin-converting enzyme inhibitor
 DG03231  Antihypertensive
  DG01501  Angiotensin-converting enzyme inhibitor
Remark
Therapeutic category: 2144 2179
ATC code: C09AA03
Chemical structure group: DG00336
Product (DG00336): D00362<JP/US>
Product (mixture): D10268<US>
Efficacy
Antihypertensive, Angiotensin-converting enzyme inhibitor
  Disease
Hypertension [DS:H01633]
Target
ACE (CD143) [HSA:1636] [KO:K01283]
  Pathway
hsa04614  Renin-angiotensin system
Interaction
Structure map
map07217  Renin-angiotensin system inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C09 AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
   C09A ACE INHIBITORS, PLAIN
    C09AA ACE inhibitors, plain
     C09AA03 Lisinopril
      D00362  Lisinopril (USP) <JP/US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Angiotensin-converting Enzyme (ACE) Inhibitors
   Lisinopril
    D00362  Lisinopril (USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   214  Antihypertensives
    2144  Angiotensin converting enzyme inhibitors
     D00362  Lisinopril (USP); Lisinopril hydrate (JP18)
   217  Vasodilators
    2179  Others
     D00362  Lisinopril (USP); Lisinopril hydrate (JP18)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01925  Renin-angiotensin system inhibitor
   DG01501  Angiotensin-converting enzyme inhibitor
    DG00336  Lisinopril
     D00362  Lisinopril
  DG03231  Antihypertensive
   DG01501  Angiotensin-converting enzyme inhibitor
    DG00336  Lisinopril
     D00362  Lisinopril
Drug classes [BR:br08332]
 Cardiovascular agent
  DG01501  Angiotensin-converting enzyme inhibitor
   D00362  Lisinopril
  DG03231  Antihypertensive
   D00362  Lisinopril
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases (EC3)
   Peptidyl-dipeptidases
    ACE (CD143)
     D00362  Lisinopril (USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00362  Lisinopril hydrate
  D00362  Lisinopril tablets
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01925  Renin-angiotensin system inhibitor
   DG01501  Angiotensin-converting enzyme inhibitor
    DG00336  Lisinopril
  DG03231  Antihypertensive
   DG01501  Angiotensin-converting enzyme inhibitor
    DG00336  Lisinopril
Other DBs
CAS: 83915-83-7
PubChem: 7847428
ChEBI: 6503
LigandBox: D00362
KCF data

ATOM        31
            1   N1y N    35.2006  -17.8564
            2   C1y C    36.3299  -18.6909
            3   C5a C    33.9897  -18.5524
            4   C1x C    35.6541  -16.5295
            5   C1x C    37.4720  -17.8812
            6   C6a C    36.3139  -20.0906
            7   C1c C    32.7788  -17.8504
            8   O5a O    33.9897  -19.9506
            9   C1x C    37.0595  -16.5467
            10  O6a O    37.5141  -20.8049
            11  O6a O    35.0922  -20.7744
            12  N1b N    31.5622  -18.5524
            13  C1b C    32.7788  -16.4524
            14  C1c C    30.3513  -17.8504
            15  C1b C    33.9897  -15.7564
            16  C1b C    29.1403  -18.5466
            17  C6a C    30.3513  -16.4524
            18  C1b C    33.9897  -14.3524
            19  C1b C    27.9294  -17.8504
            20  O6a O    31.5679  -15.7504
            21  O6a O    29.1403  -15.7504
            22  C1b C    32.7788  -13.6504
            23  C8y C    26.7185  -18.5466
            24  N1a N    31.5679  -14.3524
            25  C8x C    26.7185  -19.9447
            26  C8x C    25.5076  -17.8447
            27  C8x C    25.5076  -20.6466
            28  C8x C    24.2910  -18.5466
            29  C8x C    24.2910  -19.9447
            30  O0  O    41.5543  -17.3474
            31  O0  O    41.5543  -17.3474
BOND        30
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1 #Up
            6     3   7 1
            7     3   8 2
            8     4   9 1
            9     6  10 1
            10    6  11 2
            11    7  12 1
            12    7  13 1 #Up
            13   12  14 1
            14   13  15 1
            15   14  16 1
            16   14  17 1 #Up
            17   15  18 1
            18   16  19 1
            19   17  20 1
            20   17  21 2
            21   18  22 1
            22   19  23 1
            23   22  24 1
            24   23  25 1
            25   23  26 2
            26   25  27 2
            27   26  28 1
            28   27  29 1
            29    5   9 1
            30   28  29 2
BRACKET     1    39.6900  -18.2700   39.6900  -16.4500
            1    42.0000  -16.4500   42.0000  -18.2700
            1  2
 ORIGINAL  1   30
 REPEAT    1   31