Entry

D00365                      Drug

Name

Lorazepam (JP18/USP/INN);
Ativan (TN)

Product

LOREEV XR (Almatica Pharma LLC), ATIVAN (Bausch Health US LLC), LORAZEPAM (Civica), LORAZEPAM (Hikma Pharmaceuticals USA), ATIVAN (Hikma Pharmaceuticals USA), LORAZEPAM (Hikma Pharmaceuticals USA), LORAZEPAM (Hikma Pharmaceuticals USA)

Generic

LORAZEPAM (A-S Medication Solutions), LORAZEPAM (A-S Medication Solutions), LORAZEPAM (A-S Medication Solutions), LORAZEPAM (A-S Medication Solutions), LORAZEPAM (A-S Medication Solutions), LORAZEPAM (A-S Medication Solutions), LORAZEPAM (A-S Medication Solutions), LORAZEPAM (A-S Medication Solutions), LORAZEPAM (A-S Medication Solutions), LORAZEPAM (A-S Medication Solutions), LORAZEPAM (ATLANTIC BIOLOGICALS CORP.), LORAZEPAM (ATLANTIC BIOLOGICALS CORP.), LORAZEPAM (Actavis Pharma), LORAZEPAM (Akorn), LORAZEPAM (Akorn), LORAZEPAM (American Health Packaging), LORAZEPAM (American Health Packaging), LORAZEPAM (Amneal Pharmaceuticals LLC), LORAZEPAM (Amneal Pharmaceuticals LLC), LORAZEPAM (Aphena Pharma Solutions - Tennessee), LORAZEPAM (Aphena Pharma Solutions - Tennessee), LORAZEPAM (Aphena Pharma Solutions - Tennessee), LORAZEPAM (Aphena Pharma Solutions - Tennessee), LORAZEPAM (Aphena Pharma Solutions - Tennessee), LORAZEPAM (Aphena Pharma Solutions - Tennessee), LORAZEPAM (Aphena Pharma Solutions - Tennessee), LORAZEPAM (Aphena Pharma Solutions - Tennessee), LORAZEPAM (Aphena Pharma Solutions - Tennessee), LORAZEPAM (Aphena Pharma Solutions - Tennessee), LORAZEPAM (Aphena Pharma Solutions - Tennessee), LORAZEPAM (Aurolife Pharma), LORAZEPAM (Bryant Ranch Prepack), LORAZEPAM (Bryant Ranch Prepack), LORAZEPAM (Bryant Ranch Prepack), LORAZEPAM (Bryant Ranch Prepack), LORAZEPAM (Bryant Ranch Prepack), LORAZEPAM (Bryant Ranch Prepack), LORAZEPAM (Bryant Ranch Prepack), LORAZEPAM (Cardinal Health 107), LORAZEPAM (Clinical Solutions Wholesale), LORAZEPAM (DIRECT RX), LORAZEPAM (DirectRX), LORAZEPAM (DirectRx), LORAZEPAM (Direct_Rx), LORAZEPAM (Hospira), LORAZEPAM (Hospira), LORAZEPAM (Hospira), LORAZEPAM (International Medication Systems), LORAZEPAM (Leading Pharma), LORAZEPAM (Major Pharmaceuticals), LORAZEPAM (Medsource Pharmaceuticals), LORAZEPAM (NCS HealthCare of KY), LORAZEPAM (NuCare Pharmaceuticals), LORAZEPAM (NuCare Pharmaceuticals), LORAZEPAM (NuCare Pharmaceuticals), LORAZEPAM (NuCare Pharmaceuticals), LORAZEPAM (NuCare Pharmaceuticals), LORAZEPAM (NuCare Pharmaceuticals), LORAZEPAM (NuCare Pharmaceuticals), LORAZEPAM (NuCare Pharmaceuticals), LORAZEPAM (NuCare Pharmaceuticals), LORAZEPAM (NuCare Pharmaceuticals), LORAZEPAM (NuCare Pharmaceuticals), LORAZEPAM (NuCare Pharmaceuticals), LORAZEPAM (NuCare Pharmaceuticals), LORAZEPAM (NuCare Pharmaceuticals), LORAZEPAM (NuCare Pharmaceuticals), LORAZEPAM (NuCare Pharmaceuticals), LORAZEPAM (PD-Rx Pharmaceuticals), LORAZEPAM (PD-Rx Pharmaceuticals), LORAZEPAM (PD-Rx Pharmaceuticals), LORAZEPAM (PD-Rx Pharmaceuticals), LORAZEPAM (PD-Rx Pharmaceuticals), LORAZEPAM (PharmPak), LORAZEPAM (PharmPak), LORAZEPAM (Pharmaceutical Associates), LORAZEPAM (Preferred Pharmaceuticals), LORAZEPAM (Preferred Pharmaceuticals), LORAZEPAM (Preferred Pharmaceuticals), LORAZEPAM (Proficient Rx LP), LORAZEPAM (Proficient Rx LP), LORAZEPAM (Proficient Rx LP), LORAZEPAM (Proficient Rx LP), LORAZEPAM (Proficient Rx LP), LORAZEPAM (Quality Care Products), LORAZEPAM (Quality Care Products), LORAZEPAM (REMEDYREPACK), LORAZEPAM (REMEDYREPACK), LORAZEPAM (REMEDYREPACK), LORAZEPAM (REMEDYREPACK), LORAZEPAM (REMEDYREPACK), LORAZEPAM (REMEDYREPACK), LORAZEPAM (REMEDYREPACK), LORAZEPAM (REMEDYREPACK), LORAZEPAM (REMEDYREPACK), LORAZEPAM (REMEDYREPACK), LORAZEPAM (REMEDYREPACK), LORAZEPAM (RPK Pharmaceuticals), LORAZEPAM (RPK Pharmaceuticals), LORAZEPAM (RPK Pharmaceuticals), LORAZEPAM (RedPharm Drug), LORAZEPAM (RedPharm Drug), LORAZEPAM (RedPharm Drug), LORAZEPAM (RedPharm Drug), LORAZEPAM (St. Mary's Medical Park Pharmacy), LORAZEPAM (Teva Pharmaceuticals USA), LORAZEPAM (West-Ward Pharmaceuticals Corp.)

Formula

C15H10Cl2N2O2

Exact mass

320.0119

Mol weight

321.1581

Structure

Simcomp

Class

Neuropsychiatric agent
DG01567  GABA-A receptor agonist
DG01914  Anxiolytics, benzodiazepine derivatives
DG03199  Antiepileptic agent
Metabolizing enzyme substrate
DG02924  UGT substrate
  DG03190  UGT2B7 substrate
  DG03187  UGT2B15 substrate

Remark

Therapeutic category:

1124 1139

ATC code:

N05BA06

Product:

D00365<JP/US>

Efficacy

Antianxiety, Anticonvulsant, Minor tranquilizer

Comment

Benzodiazepine derivative

Target

GABR [HSA:2554 2555 2556 2557 2558 2559 2560 2561 2562 2563 2564 2565 2566 2567 2568 55879] [KO:K05175 K05181 K05184 K05185 K05186 K05189 K05192]

Pathway

hsa04080

Neuroactive ligand-receptor interaction

hsa04727

GABAergic synapse

Metabolism

Enzyme: UGT2B7 [HSA:7364], UGT2B15 [HSA:7366]

Interaction

Structure map

map07030

Anxiolytics

map07230

GABA-A receptor agonists/antagonists

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05B ANXIOLYTICS
    N05BA Benzodiazepine derivatives
     N05BA06 Lorazepam
      D00365  Lorazepam (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Anticonvulsants
  Gamma-aminobutyric Acid (GABA) Augmenting Agents
   Benzodiazepines
    Lorazepam
     D00365  Lorazepam (JP18/USP/INN)
Anxiolytics
  Benzodiazepines
   Lorazepam
    D00365  Lorazepam (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   112  Hypnotics and sedatives, anxiolytics
    1124  Benzodiazepins
     D00365  Lorazepam (JP18/USP/INN)
   113  Antiepileptics
    1139  Others
     D00365  Lorazepam (JP18/USP/INN)
Drug groups [BR:br08330]
Neuropsychiatric agent
  DG01567  GABA-A receptor agonist
   D00365  Lorazepam
  DG01914  Anxiolytics, benzodiazepine derivatives
   D00365  Lorazepam
  DG03199  Antiepileptic agent
   D00365  Lorazepam
Metabolizing enzyme substrate
  DG02924  UGT substrate
   DG03190  UGT2B7 substrate
    D00365  Lorazepam
   DG03187  UGT2B15 substrate
    D00365  Lorazepam
Target-based classification of drugs [BR:br08310]
Ion channels
  Ligand-gated ion channels
   GABA (ionotropic)
    GABR
     D00365  Lorazepam (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
  D00365  Lorazepam
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
  D00365

Other DBs

CAS:

846-49-1

PubChem:

7847431

ChEBI:

6539

LigandBox:

D00365

NIKKAJI:

J3.337E

KCF data

ATOM        21
            1   C2y C    19.5808  -11.8131
            2   C8y C    18.7361  -10.7001
            3   C8y C    19.0723   -9.3392
            4   N1x N    20.3372   -8.7593
            5   N2x N    20.9909  -11.8384
            6   C5x C    21.5946   -9.3835
            7   C1y C    21.8820  -10.7564
            8   C8x C    18.0621   -8.3678
            9   C8x C    16.7160   -8.7571
            10  C8y C    16.3798  -10.1180
            11  C8x C    17.3900  -11.0891
            12  O1a O    23.2172  -11.1948
            13  O5x O    22.6419   -8.4462
            14  X   Cl   15.0268  -10.5091
            15  C8y C    18.8591  -13.0128
            16  C8x C    17.4591  -13.0128
            17  C8x C    16.7591  -14.2252
            18  C8x C    17.4591  -15.4377
            19  C8x C    18.8591  -15.4377
            20  C8y C    19.5591  -14.2252
            21  X   Cl   20.9299  -14.2249
BOND        23
            1     3   4 1
            2     1   5 2
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    2  11 2
            13    7  12 1
            14    6  13 2
            15   10  14 1
            16    1  15 1
            17   15  16 1
            18   16  17 2
            19   17  18 1
            20   18  19 2
            21   19  20 1
            22   15  20 2
            23   20  21 1