| Entry |
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| Name | Torsemide (USP); Torasemide (JAN/INN); Demadex (TN); Luprac (TN) | ||||||||||
| Product | SOAANZ (Sarfez Pharmaceuticals) | ||||||||||
| Generic | TORSEMIDE (American Health Packaging), TORSEMIDE (American Regent), TORSEMIDE (Aphena Pharma Solutions - Tennessee), TORSEMIDE (Aurobindo Pharma Limited), TORSEMIDE (AvKARE), TORSEMIDE (AvPAK), TORSEMIDE (Bryant Ranch Prepack), TORSEMIDE (Bryant Ranch Prepack), TORSEMIDE (Bryant Ranch Prepack), TORSEMIDE (Camber Pharmaceuticals), TORSEMIDE (Direct_Rx), TORSEMIDE (Golden State Medical Supply), TORSEMIDE (NCS HealthCare of KY), TORSEMIDE (REMEDYREPACK), TORSEMIDE (REMEDYREPACK), TORSEMIDE (Rising Health), TORSEMIDE (Teva Pharmaceuticals USA), TORSEMIDE (West-Ward Pharmaceuticals Corp.) | ||||||||||
| Formula | C16H20N4O3S | ||||||||||
| Exact mass | 348.1256 | ||||||||||
| Mol weight | 348.42 | ||||||||||
| Structure |  | ||||||||||
| Simcomp | |||||||||||
| Class | Cardiovascular agent DG01690 Sulfonamide diuretic DG01747 Furosemide type diuretic DG01748 Loop diuretic DG01747 Furosemide type diuretic Metabolizing enzyme substrate DG02918 CYP2C8 substrate DG01642 CYP2C9 substrate | ||||||||||
| Remark |
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| Efficacy | Diuretic, Na-K-Cl cotransporter inhibitor | ||||||||||
| Disease | Hypertension [DS:H01633] | ||||||||||
| Comment | loop diuretic Sulfonamide derivative | ||||||||||
| Target | SLC12A1 (NKCC2) [HSA:6557] [KO:K14425] SLC12A2 (NKCC1) [HSA:6558] [KO:K10951] | ||||||||||
| Metabolism | Enzyme: CYP2C9 [HSA:1559], CYP2C8 [HSA:1558] | ||||||||||
| Interaction | |||||||||||
| Structure map |
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| Brite | Anatomical Therapeutic Chemical (ATC) classification [BR:br08303] C CARDIOVASCULAR SYSTEM C03 DIURETICS C03C HIGH-CEILING DIURETICS C03CA Sulfonamides, plain C03CA04 Torasemide D00382 Torsemide (USP) <JP/US> USP drug classification [BR:br08302] Cardiovascular Agents Diuretics, Loop Torsemide D00382 Torsemide (USP) Therapeutic category of drugs in Japan [BR:br08301] 2 Agents affecting individual organs 21 Cardiovascular agents 213 Diuretics 2139 Others D00382 Torsemide (USP); Torasemide (JAN/INN) Drug groups [BR:br08330] Cardiovascular agent DG01690 Sulfonamide diuretic DG01747 Furosemide type diuretic DG00273 Torasemide D00382 Torsemide DG01748 Loop diuretic DG01747 Furosemide type diuretic DG00273 Torasemide D00382 Torsemide Metabolizing enzyme substrate DG02918 CYP2C8 substrate DG00273 Torasemide D00382 Torsemide DG01642 CYP2C9 substrate DG00273 Torasemide D00382 Torsemide Target-based classification of drugs [BR:br08310] Transporters Solute carrier family SLC12 SLC12A1 (NKCC2) D00382 Torsemide (USP) <JP/US> SLC12A2 (NKCC1) D00382 Torsemide (USP) <JP/US> Drug metabolizing enzymes and transporters [br08309.html] Drug metabolizing enzymes D00382 Drug groups [BR:br08330] Cardiovascular agent DG01690 Sulfonamide diuretic DG01747 Furosemide type diuretic DG00273 Torasemide DG01748 Loop diuretic DG01747 Furosemide type diuretic DG00273 Torasemide Metabolizing enzyme substrate DG02918 CYP2C8 substrate DG00273 Torasemide DG01642 CYP2C9 substrate DG00273 Torasemide | ||||||||||
| Other DBs |
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| KCF data | ATOM 24 1 C8y C 26.1216 -19.9949 2 C8y C 27.3390 -19.3074 3 S4a S 24.9155 -19.3074 4 C8x C 26.1156 -21.3989 5 N1b N 27.3974 -17.8975 6 C8x C 28.5510 -20.0066 7 N1b N 23.7036 -20.0066 8 O3c O 25.9060 -18.3054 9 O3c O 23.9135 -18.3054 10 N5x N 27.3274 -22.1097 11 C8y C 28.5393 -17.1867 12 C8x C 28.5451 -21.4106 13 C5a C 22.4919 -19.3132 14 C8x C 28.5393 -15.7884 15 C8x C 29.7453 -17.8916 16 N1b N 21.2800 -20.0123 17 O5a O 22.4860 -17.9149 18 C8y C 29.7453 -15.0952 19 C8x C 30.9571 -17.1926 20 C1c C 20.0799 -19.3191 21 C8x C 30.9571 -15.7943 22 C1a C 29.7453 -13.6969 23 C1a C 18.8681 -20.0182 24 C1a C 20.0740 -17.9208 BOND 25 1 1 2 1 2 1 3 1 3 1 4 2 4 2 5 1 5 2 6 2 6 3 7 1 7 3 8 2 8 3 9 2 9 4 10 1 10 5 11 1 11 6 12 1 12 7 13 1 13 11 14 1 14 11 15 2 15 13 16 1 16 13 17 2 17 14 18 2 18 15 19 1 19 16 20 1 20 18 21 1 21 18 22 1 22 20 23 1 23 20 24 1 24 10 12 2 25 19 21 2 |