| Entry |
| ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Name | Trandolapril (JAN/USP/INN); Mavik (TN) | ||||||||||
| Product | |||||||||||
| Generic | TRANDOLAPRIL (A-S Medication Solutions), TRANDOLAPRIL (A-S Medication Solutions), TRANDOLAPRIL (Aurobindo Pharma Limited), TRANDOLAPRIL (Bryant Ranch Prepack), TRANDOLAPRIL (Bryant Ranch Prepack), TRANDOLAPRIL (Bryant Ranch Prepack), TRANDOLAPRIL (Lupin Pharmaceuticals), TRANDOLAPRIL (Rising Health), TRANDOLAPRIL (Epic Pharma) | ||||||||||
| Formula | C24H34N2O5 | ||||||||||
| Exact mass | 430.2468 | ||||||||||
| Mol weight | 430.5372 | ||||||||||
| Structure |  | ||||||||||
| Simcomp | |||||||||||
| Class | Cardiovascular agent DG01925 Renin-angiotensin system inhibitor DG01501 Angiotensin-converting enzyme inhibitor DG03231 Antihypertensive DG01501 Angiotensin-converting enzyme inhibitor | ||||||||||
| Remark |
| ||||||||||
| Efficacy | Antihypertensive, Angiotensin-converting enzyme inhibitor | ||||||||||
| Disease | Hypertension [DS:H01633] | ||||||||||
| Comment | Active form of prodrug: Trandolaprilat [CPD:C21515] | ||||||||||
| Target | ACE (CD143) [HSA:1636] [KO:K01283] | ||||||||||
| Pathway |
| ||||||||||
| Interaction | |||||||||||
| Brite | Anatomical Therapeutic Chemical (ATC) classification [BR:br08303] C CARDIOVASCULAR SYSTEM C09 AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM C09A ACE INHIBITORS, PLAIN C09AA ACE inhibitors, plain C09AA10 Trandolapril D00383 Trandolapril (JAN/USP/INN) <JP/US> USP drug classification [BR:br08302] Cardiovascular Agents Angiotensin-converting Enzyme (ACE) Inhibitors Trandolapril D00383 Trandolapril (JAN/USP/INN) Therapeutic category of drugs in Japan [BR:br08301] 2 Agents affecting individual organs 21 Cardiovascular agents 214 Antihypertensives 2144 Angiotensin converting enzyme inhibitors D00383 Trandolapril (JAN/USP/INN) Drug groups [BR:br08330] Cardiovascular agent DG01925 Renin-angiotensin system inhibitor DG01501 Angiotensin-converting enzyme inhibitor D00383 Trandolapril DG03231 Antihypertensive DG01501 Angiotensin-converting enzyme inhibitor D00383 Trandolapril Drug classes [BR:br08332] Cardiovascular agent DG01501 Angiotensin-converting enzyme inhibitor D00383 Trandolapril DG03231 Antihypertensive D00383 Trandolapril Target-based classification of drugs [BR:br08310] Enzymes Hydrolases (EC3) Peptidyl-dipeptidases ACE (CD143) D00383 Trandolapril (JAN/USP/INN) <JP/US> Prodrugs [br08324.html] D00383 | ||||||||||
| Other DBs |
| ||||||||||
| KCF data | ATOM 31 1 N1y N 28.3850 -18.5792 2 C1y C 29.6683 -19.1392 3 C1y C 28.5425 -17.1850 4 C5a C 27.1775 -19.2850 5 C1y C 30.6075 -18.1008 6 C1x C 30.1000 -20.4692 7 C1x C 29.9134 -16.8933 8 C6a C 28.5308 -15.7792 9 C1c C 25.9642 -18.5850 10 O5a O 27.1834 -20.6850 11 C1x C 31.9784 -18.3984 12 C1x C 31.4709 -20.7667 13 O6a O 29.7326 -15.0675 14 O6a O 27.3116 -15.0908 15 N1b N 24.7508 -19.2850 16 C1a C 25.9699 -17.1850 17 C1x C 32.4042 -19.7284 18 C1c C 23.5432 -18.5909 19 C1b C 22.3300 -19.2967 20 C7a C 23.5375 -17.1909 21 C1b C 21.1167 -18.6083 22 O7a O 24.7508 -16.4909 23 O6a O 22.3183 -16.4966 24 C8y C 19.9092 -19.2967 25 C1b C 24.7450 -15.0908 26 C8x C 19.9092 -20.7084 27 C8x C 18.7074 -18.6083 28 C1a C 23.5317 -14.3966 29 C8x C 18.7074 -21.4141 30 C8x C 17.4883 -19.2967 31 C8x C 17.4883 -20.7084 BOND 33 1 1 2 1 2 1 3 1 3 1 4 1 4 2 5 1 5 2 6 1 6 3 7 1 7 3 8 1 #Down 8 4 9 1 9 4 10 2 10 5 11 1 11 6 12 1 12 8 13 1 13 8 14 2 14 9 15 1 15 9 16 1 #Up 16 11 17 1 17 15 18 1 18 18 19 1 19 18 20 1 #Up 20 19 21 1 21 20 22 1 22 20 23 2 23 21 24 1 24 22 25 1 25 24 26 1 26 24 27 2 27 25 28 1 28 26 29 2 29 27 30 1 30 29 31 1 31 5 7 1 32 12 17 1 33 30 31 2 |