Tropicamide


Entry
D00397                      Drug                                   
Name
Tropicamide (JP18/USP/INN);
Mydriacyl (TN)
Product
  Generic
TROPICAMIDE (Akorn), MYDRIACYL (Alcon Laboratories), MYDRIACYL (Alcon Laboratories), TROPICAMIDE (Bausch & Lomb Incorporated), TROPICAMIDE (Henry Schein), TROPICAMIDE (Sandoz), TROPICAMIDE (Sandoz), TROPICAMIDE (Somerset Therapeutics)
Formula
C17H20N2O2
Exact mass
284.1525
Mol weight
284.3529
Structure
Class
Neuropsychiatric agent
 DG01491  Muscarinic cholinergic receptor antagonist
Remark
Therapeutic category: 1311
ATC code: S01FA06
Product: D00397<JP/US>
Product (mixture): D04081<JP> D11625<US>
Efficacy
Mydriatic, Muscarinic acetylcholine receptor antagonist
Target
CHRM [HSA:1128 1129 1131 1132 1133] [KO:K04129 K04130 K04131 K04132 K04133]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04725  Cholinergic synapse
hsa04970  Salivary secretion
hsa04971  Gastric acid secretion
Interaction
Structure map
map07220  Cholinergic and anticholinergic drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01F MYDRIATICS AND CYCLOPLEGICS
    S01FA Anticholinergics
     S01FA06 Tropicamide
      D00397  Tropicamide (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Ophthalmic Agents
  Ophthalmic Agents, Other
   Tropicamide
    D00397  Tropicamide (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1311  Mydriatic agents
     D00397  Tropicamide (JP18/USP/INN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01491  Muscarinic cholinergic receptor antagonist
   D00397  Tropicamide
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    CHRM
     D00397  Tropicamide (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00397  Tropicamide
Other DBs
CAS: 1508-75-4
PubChem: 7847463
ChEBI: 9757
LigandBox: D00397
NIKKAJI: J3.670F
KCF data

ATOM        21
            1   C1c C    24.0800  -21.3500
            2   C8y C    25.3400  -21.9800
            3   C5a C    22.8900  -22.0500
            4   C1b C    24.0800  -19.9500
            5   C8x C    26.5300  -21.2800
            6   C8x C    25.3400  -23.3800
            7   N1c N    21.7000  -21.3500
            8   O5a O    22.8900  -23.4500
            9   O1a O    25.3400  -19.2500
            10  C8x C    27.7200  -21.9800
            11  C8x C    26.5300  -24.0800
            12  C1b C    20.4400  -22.0500
            13  C1b C    21.7000  -19.9500
            14  C8x C    27.7200  -23.3800
            15  C8y C    19.2500  -21.3500
            16  C1a C    22.8900  -19.1800
            17  C8x C    19.2500  -19.9500
            18  C8x C    18.0600  -22.0500
            19  C8x C    18.0600  -19.2500
            20  C8x C    16.8000  -21.3500
            21  N5x N    16.8000  -19.8800
BOND        22
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 2
            5     2   6 1
            6     3   7 1
            7     3   8 2
            8     4   9 1
            9     5  10 1
            10    6  11 2
            11    7  12 1
            12    7  13 1
            13   10  14 2
            14   12  15 1
            15   13  16 1
            16   15  17 2
            17   15  18 1
            18   17  19 1
            19   18  20 2
            20   19  21 2
            21   11  14 1
            22   20  21 1