Entry

D00398                      Drug

Name

Valacyclovir hydrochloride (USP);
Valaciclovir hydrochloride (JP18);
Valtrex (TN)

Product

VALTREX (GlaxoSmithKline LLC), VALTREX (REMEDYREPACK), VALTREX (RedPharm Drug)

Generic

VALACYCLOVIR (A-S Medication Solutions), VALACYCLOVIR HYDROCHLORIDE (Bryant Ranch Prepack), VALACYCLOVIR (Cadila Healthcare Limited), VALACYCLOVIR (Camber Pharmaceuticals), VALACYCLOVIR (Denton Pharma), VALACYCLOVIR (DirectRX), VALACYCLOVIR (Golden State Medical Supply), VALACYCLOVIR (McKesson Corporation dba SKY Packaging), VALACYCLOVIR HYDROCHLORIDE (Mylan Pharmaceuticals), VALACYCLOVIR (NuCare Pharmaceuticals), VALACYCLOVIR (NuCare Pharmaceuticals), VALACYCLOVIR (NuCare Pharmaceuticals), VALACYCLOVIR (NuCare Pharmaceuticals), VALACYCLOVIR (Preferred Pharmaceuticals), VALACYCLOVIR (Quality Care Products), VALACYCLOVIR HYDROCHLORIDE (REMEDYREPACK), VALACYCLOVIR (RedPharm Drug), VALACYCLOVIR (SUN PHARMACEUTICAL INDUSTRIES), VALACYCLOVIR (St. Mary's Medical Park Pharmacy), VALACYCLOVIR (Yiling Pharmaceutical), VALACYCLOVIR HYDROCHLORIDE (A-S Medication Solutions), VALACYCLOVIR HYDROCHLORIDE (A-S Medication Solutions), VALACYCLOVIR HYDROCHLORIDE (A-S Medication Solutions), VALACYCLOVIR HYDROCHLORIDE (A-S Medication Solutions), VALACYCLOVIR (ACETRIS HEALTH), VALACYCLOVIR HYDROCHLORIDE (American Health Packaging), VALACYCLOVIR (Aphena Pharma Solutions - Tennessee), VALACYCLOVIR HYDROCHLORIDE (Asclemed USA), VALACYCLOVIR HYDROCHLORIDE (Aurobindo Pharma Limited), VALACYCLOVIR HYDROCHLORIDE (AvPAK), VALACYCLOVIR HYDROCHLORIDE (Bryant Ranch Prepack), VALACYCLOVIR HYDROCHLORIDE (Bryant Ranch Prepack), VALACYCLOVIR HYDROCHLORIDE (Bryant Ranch Prepack), VALACYCLOVIR HYDROCHLORIDE (Bryant Ranch Prepack), VALACYCLOVIR HYDROCHLORIDE (Bryant Ranch Prepack), VALACYCLOVIR HYDROCHLORIDE (Bryant Ranch Prepack), VALACYCLOVIR HYDROCHLORIDE (Cardinal Health), VALACYCLOVIR HYDROCHLORIDE (Cipla USA), VALACYCLOVIR HYDROCHLORIDE (DIRECT RX), VALACYCLOVIR HYDROCHLORIDE (Denton Pharma), VALACYCLOVIR HYDROCHLORIDE (Dr. Reddys Laboratories Limited), VALACYCLOVIR HYDROCHLORIDE (Jubilant Cadista Pharmaceuticals), VALACYCLOVIR HYDROCHLORIDE (Major Pharmaceuticals), VALACYCLOVIR HYDROCHLORIDE (McKesson Corporation dba SKY Packaging), VALACYCLOVIR HYDROCHLORIDE (Mylan Institutional), VALACYCLOVIR HYDROCHLORIDE (NorthStar Rx LLC), VALACYCLOVIR HYDROCHLORIDE (NuCare Pharmaceuticals), VALACYCLOVIR HYDROCHLORIDE (NuCare Pharmaceuticals), VALACYCLOVIR HYDROCHLORIDE (NuCare Pharmaceuticals), VALACYCLOVIR HYDROCHLORIDE (NuCare Pharmaceuticals), VALACYCLOVIR HYDROCHLORIDE (NuCare Pharmaceuticals), VALACYCLOVIR HYDROCHLORIDE (NuCare Pharmaceuticals), VALACYCLOVIR HYDROCHLORIDE (NuCare Pharmaceuticals), VALACYCLOVIR HYDROCHLORIDE (NuCare Pharmaceuticals), VALACYCLOVIR HYDROCHLORIDE (NuCare Pharmaceuticals), VALACYCLOVIR HYDROCHLORIDE (NuCare Pharmaceuticals), VALACYCLOVIR HYDROCHLORIDE (PD-Rx Pharmaceuticals), VALACYCLOVIR HYDROCHLORIDE (PD-Rx Pharmaceuticals), VALACYCLOVIR HYDROCHLORIDE (PD-Rx Pharmaceuticals), VALACYCLOVIR HYDROCHLORIDE (PD-Rx Pharmaceuticals), VALACYCLOVIR HYDROCHLORIDE (Preferred Pharmaceuticals), VALACYCLOVIR HYDROCHLORIDE (Preferred Pharmaceuticals), VALACYCLOVIR HYDROCHLORIDE (Preferred Pharmaceuticals), VALACYCLOVIR HYDROCHLORIDE (Preferred Pharmaceuticals), VALACYCLOVIR HYDROCHLORIDE (Proficient Rx LP), VALACYCLOVIR HYDROCHLORIDE (Proficient Rx LP), VALACYCLOVIR HYDROCHLORIDE (Proficient Rx LP), VALACYCLOVIR HYDROCHLORIDE (Proficient Rx LP), VALACYCLOVIR HYDROCHLORIDE (REMEDYREPACK), VALACYCLOVIR HYDROCHLORIDE (REMEDYREPACK), VALACYCLOVIR HYDROCHLORIDE (REMEDYREPACK), VALACYCLOVIR HYDROCHLORIDE (REMEDYREPACK), VALACYCLOVIR HYDROCHLORIDE (REMEDYREPACK), VALACYCLOVIR HYDROCHLORIDE (RPK Pharmaceuticals), VALACYCLOVIR HYDROCHLORIDE (RPK Pharmaceuticals), VALACYCLOVIR HYDROCHLORIDE (RedPharm Drug), VALACYCLOVIR HYDROCHLORIDE (RedPharm Drug), VALACYCLOVIR HYDROCHLORIDE (RedPharm Drug), VALACYCLOVIR HYDROCHLORIDE (Rising Health), VALACYCLOVIR HYDROCHLORIDE (Sandoz), VALACYCLOVIR HYDROCHLORIDE (TIME CAP LABORATORIES), VALACYCLOVIR HYDROCHLORIDE (Wockhardt USA LLC.)

Formula

C13H20N6O4. HCl

Exact mass

360.1313

Mol weight

360.7966

Structure

Simcomp

Class

Antiviral
DG02840 Anti-herpesvirus agent

Remark

Same as:

C07184

Therapeutic category:

6250

ATC code:

J05AB11

Chemical structure group:

DG00647

Product (DG00647):

D00398<JP/US> D10518<JP/US>

Efficacy

Antiviral, DNA polymerase inhibitor

Disease

Herpes labialis [DS:H00365]
Genital herpes [DS:H00365]
Herpes zoster [DS:H00366]
Chickenpox [DS:H00366]

Comment

Active form of prodrug: Aciclovir [DR:D00222]

Target

Herpesvirus DNA polymerase [KO:K18964]

Pathway

ko03240

Viral replication

Interaction

Structure map

map07044

Antiviral agents

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
J ANTIINFECTIVES FOR SYSTEMIC USE
  J05 ANTIVIRALS FOR SYSTEMIC USE
   J05A DIRECT ACTING ANTIVIRALS
    J05AB Nucleosides and nucleotides excl. reverse transcriptase inhibitors
     J05AB11 Valaciclovir
      D00398  Valacyclovir hydrochloride (USP) <JP/US>
USP drug classification [BR:br08302]
Antivirals
  Antiherpetic Agents
   Valacyclovir
    D00398  Valacyclovir hydrochloride (USP)
Therapeutic category of drugs in Japan [BR:br08301]
6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   625  Antivirals
    6250  Antivirals
     D00398  Valacyclovir hydrochloride (USP); Valaciclovir hydrochloride (JP18)
Drug groups [BR:br08330]
Antiviral
  DG02840  Anti-herpesvirus agent
   DG00647  Valaciclovir
    D00398  Valacyclovir hydrochloride
Drug classes [BR:br08332]
Antiviral
  DG02840  Anti-herpesvirus agent
   D00398  Valacyclovir hydrochloride
Antimicrobials [BR:br08307]
Antivirals
  Genome replication inhibitor
   Herpesvirus DNA polymerase inhibitor
    D00398  Valacyclovir hydrochloride (USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
  D00398  Valaciclovir hydrochloride
  D00398  Valaciclovir hydrochloride tablets
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
  D00398
Drug groups [BR:br08330]
Antiviral
  DG02840  Anti-herpesvirus agent
   DG00647  Valaciclovir
Antimicrobials abbreviations [BR:br08327]
Antivirals
  Genome replication inhibitor
   Herpesvirus DNA polymerase inhibitor
    DG00647  Valaciclovir
Prodrugs [br08324.html]
DG00647

Other DBs

CAS:	124832-27-5

PubChem:

7847464

ChEBI:

9919

LigandBox:

D00398

NIKKAJI:

J1.402.670C

KCF data

ATOM        24
            1   X   Cl   33.8079  -15.4658
            2   N4y N    26.2500  -17.2200
            3   C8y C    27.5100  -16.7300
            4   C8y C    27.5100  -15.3300
            5   N5x N    26.1800  -14.9100
            6   C8x C    25.4100  -16.1000
            7   N5x N    28.7700  -17.4300
            8   C8y C    29.9600  -16.7300
            9   N4x N    29.9600  -15.3300
            10  C8y C    28.7000  -14.5600
            11  O5x O    28.7000  -13.1600
            12  N1a N    31.2200  -17.3600
            13  C1b C    26.2500  -18.6200
            14  O2a O    24.9900  -19.3200
            15  C1b C    23.8000  -18.6200
            16  C1b C    22.5400  -19.3200
            17  O7a O    21.3500  -18.6200
            18  C7a C    20.0900  -19.2500
            19  C1c C    18.9000  -18.6200
            20  C1c C    17.7100  -19.2500
            21  C1a C    16.5200  -18.5500
            22  C1a C    17.7100  -20.7200
            23  O6a O    20.0900  -20.7200
            24  N1a N    18.9000  -17.2200
BOND        24
            1     2   3 1
            2     3   4 2
            3     4   5 1
            4     5   6 2
            5     2   6 1
            6     3   7 1
            7     7   8 2
            8     8   9 1
            9     9  10 1
            10    4  10 1
            11   10  11 2
            12    8  12 1
            13    2  13 1
            14   13  14 1
            15   14  15 1
            16   15  16 1
            17   16  17 1
            18   17  18 1
            19   18  19 1
            20   19  20 1
            21   20  21 1
            22   20  22 1
            23   18  23 2
            24   19  24 1 #Down