| Entry |
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|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Name | Valsartan (JP18/USP/INN); Diovan (TN) | ||||||||||||
| Product | DIOVAN (Novartis Pharmaceuticals Corporation) | ||||||||||||
| Generic | VALSARTAN (A-S Medication Solutions), VALSARTAN (A-S Medication Solutions), VALSARTAN (A-S Medication Solutions), VALSARTAN (A-S Medication Solutions), VALSARTAN (A-S Medication Solutions), VALSARTAN (A-S Medication Solutions), VALSARTAN (A-S Medication Solutions), VALSARTAN (A-S Medication Solutions), VALSARTAN (A-S Medication Solutions), VALSARTAN (A-S Medication Solutions), VALSARTAN (Alembic Pharmaceuticals), VALSARTAN (Alembic Pharmaceuticals Limited), VALSARTAN (American Health Packaging), VALSARTAN (Amneal Pharmaceuticals LLC), VALSARTAN (Aphena Pharma Solutions - Tennessee), VALSARTAN (Archis Pharma LLC), VALSARTAN (Ascend Laboratories), VALSARTAN (Aurobindo Pharma Limited), VALSARTAN (AvKARE), VALSARTAN (AvPAK), VALSARTAN (Bryant Ranch Prepack), VALSARTAN (Bryant Ranch Prepack), VALSARTAN (Bryant Ranch Prepack), VALSARTAN (Bryant Ranch Prepack), VALSARTAN (Bryant Ranch Prepack), VALSARTAN (Bryant Ranch Prepack), VALSARTAN (Bryant Ranch Prepack), VALSARTAN (Bryant Ranch Prepack), VALSARTAN (Bryant Ranch Prepack), VALSARTAN (Bryant Ranch Prepack), VALSARTAN (Bryant Ranch Prepack), VALSARTAN (Bryant Ranch Prepack), VALSARTAN (Camber Pharmaceuticals), VALSARTAN (Camber Pharmaceuticals), VALSARTAN (Direct_Rx), VALSARTAN (Direct_Rx), VALSARTAN (Direct_Rx), VALSARTAN (Direct_Rx), VALSARTAN (Dr. Reddy's Laboratories Limited), VALSARTAN (Jubilant Cadista Pharmaceuticals), VALSARTAN (Lifsa Drugs LLC), VALSARTAN (Lupin Pharmaceuticals), VALSARTAN (Macleods Pharmaceuticals Limited), VALSARTAN (Medsource Pharmaceuticals), VALSARTAN (Medsource Pharmaceuticals), VALSARTAN (Mylan Pharmaceuticals), VALSARTAN (Ohm Laboratories), VALSARTAN (Proficient Rx LP), VALSARTAN (Proficient Rx LP), VALSARTAN (SQUARE PHARMACEUTICALS LIMITED), VALSARTAN (ScieGen Pharmaceuticals), VALSARTAN (Solco Healthcare US), VALSARTAN (Unichem Pharmaceuticals (USA)) | ||||||||||||
| Formula | C24H29N5O3 | ||||||||||||
| Exact mass | 435.227 | ||||||||||||
| Mol weight | 435.5188 | ||||||||||||
| Structure |  | ||||||||||||
| Class | Cardiovascular agent DG01925 Renin-angiotensin system inhibitor DG01495 Angiotensin II receptor antagonist DG03231 Antihypertensive DG01495 Angiotensin II receptor antagonist Metabolizing enzyme substrate DG01642 CYP2C9 substrate Transporter substrate DG02861 ABCC2 substrate DG02856 SLCO1B1 substrate DG02932 SLCO1B3 substrate | ||||||||||||
| Remark |
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| Efficacy | Antihypertensive, Angiotensin II receptor antagonist | ||||||||||||
| Disease | Hypertension [DS:H01633] | ||||||||||||
| Target | AGTR1 [HSA:185] [KO:K04166] | ||||||||||||
| Pathway |
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| Metabolism | Enzyme: CYP2C9 [HSA:1559] Transporter: SLCO1B1 [HSA:10599], SLCO1B3 [HSA:28234], ABCC2 [HSA:1244] | ||||||||||||
| Interaction | |||||||||||||
| Structure map |
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| Other map |
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| Brite | Anatomical Therapeutic Chemical (ATC) classification [BR:br08303] C CARDIOVASCULAR SYSTEM C09 AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM C09C ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), PLAIN C09CA Angiotensin II receptor blockers, plain C09CA03 Valsartan D00400 Valsartan (JP18/USP/INN) <JP/US> USP drug classification [BR:br08302] Cardiovascular Agents Angiotensin II Receptor Antagonists Valsartan D00400 Valsartan (JP18/USP/INN) Therapeutic category of drugs in Japan [BR:br08301] 2 Agents affecting individual organs 21 Cardiovascular agents 214 Antihypertensives 2149 Others D00400 Valsartan (JP18/USP/INN) Drug groups [BR:br08330] Cardiovascular agent DG01925 Renin-angiotensin system inhibitor DG01495 Angiotensin II receptor antagonist D00400 Valsartan DG03231 Antihypertensive DG01495 Angiotensin II receptor antagonist D00400 Valsartan Metabolizing enzyme substrate DG01642 CYP2C9 substrate D00400 Valsartan Transporter substrate DG02861 ABCC2 substrate D00400 Valsartan DG02856 SLCO1B1 substrate D00400 Valsartan DG02932 SLCO1B3 substrate D00400 Valsartan Drug classes [BR:br08332] Cardiovascular agent DG01495 Angiotensin II receptor antagonist D00400 Valsartan DG03231 Antihypertensive D00400 Valsartan Target-based classification of drugs [BR:br08310] G Protein-coupled receptors Rhodopsin family Angiotensin AGTR1 D00400 Valsartan (JP18/USP/INN) <JP/US> Drugs listed in the Japanese Pharmacopoeia [BR:br08311] Chemicals D00400 Valsartan D00400 Valsartan tablets New drug approvals in Japan [br08318.html] Drugs with new active ingredients D00400 Drug metabolizing enzymes and transporters [br08309.html] Drug metabolizing enzymes D00400 Drug transporters D00400 | ||||||||||||
| Other DBs |
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| KCF data | ATOM 32 1 C8x C 19.4226 -22.2154 2 C8x C 19.4226 -23.6234 3 C8x C 20.6194 -24.3274 4 C8x C 21.8865 -23.6234 5 C8y C 21.8865 -22.2154 6 C8y C 20.6194 -21.5115 7 C8y C 23.0833 -21.5115 8 C8x C 24.2801 -22.2154 9 C8x C 25.5472 -21.5115 10 C8y C 25.5472 -20.1035 11 C8x C 24.3504 -19.3995 12 C8x C 23.0833 -20.1035 13 C8y C 20.6194 -20.1035 14 N4x N 21.7457 -19.2587 15 N5x N 21.3233 -17.9916 16 N5x N 19.9154 -17.9916 17 N5x N 19.4930 -19.2587 18 C1b C 26.7440 -19.3995 19 N1c N 26.7440 -17.9916 20 C1c C 27.9407 -17.2876 21 C5a C 25.5472 -17.2876 22 O5a O 24.3504 -17.9916 23 C1b C 25.5472 -15.8797 24 C1b C 24.3504 -15.1757 25 C1b C 24.3504 -13.7677 26 C1a C 23.1537 -13.0637 27 C6a C 29.1375 -17.9916 28 O6a O 30.3343 -17.2876 29 O6a O 29.1375 -19.3995 30 C1c C 27.9407 -15.8797 31 C1a C 26.7440 -15.1757 32 C1a C 29.1375 -15.1757 BOND 34 1 1 2 2 2 2 3 1 3 3 4 2 4 4 5 1 5 5 6 2 6 1 6 1 7 5 7 1 8 7 8 2 9 8 9 1 10 9 10 2 11 10 11 1 12 11 12 2 13 7 12 1 14 6 13 1 15 13 14 1 16 14 15 1 17 15 16 2 18 16 17 1 19 13 17 2 20 10 18 1 21 18 19 1 22 19 20 1 23 19 21 1 24 21 22 2 25 21 23 1 26 23 24 1 27 24 25 1 28 25 26 1 29 20 27 1 30 27 28 2 31 27 29 1 32 20 30 1 #Up 33 30 31 1 34 30 32 1 |