Methylprednisolone


Entry
D00407                      Drug                                   
Name
Methylprednisolone (JP18/USP/INN);
Medrol (TN)
Product
MEDROL (A-S Medication Solutions), METHYLPREDNISOLONE (Lake Erie Medical DBA Quality Care Products LLC), MEDROL (Pharmacia and Upjohn Company LLC)
  Generic
METHYLPRED DP (Direct_Rx), METHYLPREDNISOLONE (A-S Medication Solutions), METHYLPREDNISOLONE (A-S Medication Solutions), METHYLPREDNISOLONE (American Health Packaging), METHYLPREDNISOLONE (Amneal Pharmaceuticals LLC), METHYLPREDNISOLONE (Asclemed USA), METHYLPREDNISOLONE (Asclemed USA), METHYLPREDNISOLONE (BluePoint Laboratories), METHYLPREDNISOLONE (Bryant Ranch Prepack), METHYLPREDNISOLONE (Bryant Ranch Prepack), METHYLPREDNISOLONE (Bryant Ranch Prepack), METHYLPREDNISOLONE (Cadila Healthcare Limited), METHYLPREDNISOLONE (DIRECT RX), METHYLPREDNISOLONE (Doc Rx), METHYLPREDNISOLONE (Doc Rx), METHYLPREDNISOLONE (Epic Pharma), METHYLPREDNISOLONE (Greenstone LLC), METHYLPREDNISOLONE (JUBILANT CADISTA PHARMACEUTICALS), METHYLPREDNISOLONE (Lupin Pharmaceuticals), METHYLPREDNISOLONE (Major Pharmaceuticals), METHYLPREDNISOLONE (Medsource Pharmaceuticals), METHYLPREDNISOLONE (Medsource Pharmaceuticals), METHYLPREDNISOLONE (NuCare Pharmaceuticals), METHYLPREDNISOLONE (NuCare Pharmaceuticals), METHYLPREDNISOLONE (NuCare Pharmaceuticals), METHYLPREDNISOLONE (NuCare Pharmaceuticals), METHYLPREDNISOLONE (NuCare Pharmaceuticals), METHYLPREDNISOLONE (NuCare Pharmaceuticals), METHYLPREDNISOLONE (OAKRUM PHARMA), METHYLPREDNISOLONE (PD-Rx Pharmaceuticals), METHYLPREDNISOLONE (Par Pharmaceutical), METHYLPREDNISOLONE (Praxgen Pharmaceuticals LLC), METHYLPREDNISOLONE (Preferred Pharmaceuticals), METHYLPREDNISOLONE (Preferred Pharmaceuticals), METHYLPREDNISOLONE (Proficient Rx LP), METHYLPREDNISOLONE (Proficient Rx LP), METHYLPREDNISOLONE (Proficient Rx LP), METHYLPREDNISOLONE (Proficient Rx LP), METHYLPREDNISOLONE (RPK Pharmaceuticals), METHYLPREDNISOLONE (Sandoz), METHYLPREDNISOLONE (St. Mary's Medical Park Pharmacy), METHYLPREDNISOLONE (Tianjin Tianyao Pharmaceuticals), METHYLPREDNISOLONE (Unit Dose Services), METHYLPREDNISOLONE (Unit Dose Services), METHYLPREDNISOLONE (Zydus Pharmaceuticals (USA))
Formula
C22H30O5
Exact mass
374.2093
Mol weight
374.4706
Structure
Simcomp
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
Therapeutic category: 2456
ATC code: D07AA01 D10AA02 H02AB04
Chemical structure group: DG00410
Product (DG00410): D00407<JP/US> D00751<JP/US> D00979<JP/US>
Product (mixture): D04250<JP>
Efficacy
Antiallergic, Anti-inflammatory, Glucocorticoid receptor agonist
  Disease
Congenital adrenal hyperplasia [DS:H00216]
Rheumatoid arthritis [DS:H00630]
Juvenile rheumatoid arthritis [DS:H01672]
Ankylosing spondylitis [DS:H01674]
Psoriatic arthritis [DS:H01507]
Systemic lupus erythematosus [DS:H00080]
Systemic dermatomyositis and polymyositis [DS:H01604]
Bullous dermatitis herpetiformis [DS:H01362]
Erythema multiforme [DS:H01695]
Stevens-Johnson syndrome [DS:H01694]
Seborrheic dermatitis [DS:H01652]
Mycosis fungoides [DS:H01463]
Pemphigus [DS:H01648]
Severe psoriasis [DS:H01656]
Seasonal or perennial allergic rhinitis [DS:H01360]
Contact dermatitis [DS:H01357]
Bronchial asthma [DS:H00079]
Atopic dermatitis [DS:H01358]
Optic neuritis [DS:H01717]
Pulmonary tuberculosis [DS:H00342]
Acquired (autoimmune) hemolytic anemia [DS:H01585]
Nephrotic syndrome [DS:H01657]
Ulcerative colitis [DS:H01466]
Multiple sclerosis [DS:H01490]
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AA Corticosteroids, weak (group I)
     D07AA01 Methylprednisolone
      D00407  Methylprednisolone (JP18/USP/INN) <JP/US>
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AA Corticosteroids, combinations for treatment of acne
     D10AA02 Methylprednisolone
      D00407  Methylprednisolone (JP18/USP/INN) <JP/US>
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB04 Methylprednisolone
      D00407  Methylprednisolone (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Dermatological Agents
  Dermatitis and Pruitus Agents
   Glucocorticoids, High Potency
    Methylprednisolone
     D00407  Methylprednisolone (JP18/USP/INN)
 Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
  Methylprednisolone
   D00407  Methylprednisolone (JP18/USP/INN)
 Inflammatory Bowel Disease Agents
  Glucocorticoids
   Methylprednisolone
    D00407  Methylprednisolone (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   245  Adrenal hormone preparations
    2456  Prednisolones
     D00407  Methylprednisolone (JP18/USP/INN)
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG00410  Methylprednisolone
     D00407  Methylprednisolone
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00410  Methylprednisolone
     D00407  Methylprednisolone
Drug classes [BR:br08332]
 Anti-inflammatory
  DG01955  Corticosteroid
   D00407  Methylprednisolone
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D00407  Methylprednisolone (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00407  Methylprednisolone
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00407
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG00410  Methylprednisolone
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00410  Methylprednisolone
Other DBs
CAS: 83-43-2
PubChem: 7847473
ChEBI: 6888
LigandBox: D00407
NIKKAJI: J3.872E
KCF data

ATOM        27
            1   C2x C    26.6700  -18.6900
            2   C5x C    26.6700  -20.0900
            3   C2x C    27.8600  -20.7900
            4   C2y C    29.1200  -20.0900
            5   C1z C    29.1200  -18.6900
            6   C2x C    27.8600  -17.9900
            7   C1y C    30.3100  -20.7900
            8   C1x C    31.5000  -20.0900
            9   C1y C    31.5000  -18.6900
            10  C1y C    30.3100  -17.9900
            11  C1y C    32.7600  -17.9900
            12  C1z C    32.7600  -16.5900
            13  C1x C    31.5000  -15.8900
            14  C1y C    30.3100  -16.5900
            15  C1x C    35.1400  -17.9900
            16  C1x C    35.1400  -16.5900
            17  C1z C    33.9500  -15.8900
            18  O5x O    25.4800  -20.7900
            19  C1a C    29.1200  -17.2900
            20  O1a O    29.1200  -15.8900
            21  C1a C    32.7600  -15.1900
            22  C5a C    33.9500  -14.2100
            23  C1a C    30.3100  -22.1900
            24  O1a O    35.1400  -15.1900
            25  C1b C    35.1400  -13.5100
            26  O5a O    32.7600  -13.5100
            27  O1a O    36.3300  -14.2100
BOND        30
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21    2  18 2
            22    5  19 1 #Up
            23   14  20 1 #Up
            24   12  21 1 #Up
            25   17  22 1 #Up
            26    7  23 1 #Down
            27   17  24 1 #Down
            28   22  25 1
            29   22  26 2
            30   25  27 1