Methyltestosterone


Entry
D00408                      Drug                                   
Name
Methyltestosterone (JP18/USP/INN);
Android (TN);
Testred (TN)
Product
  Generic
METHITEST (Amneal Pharmaceuticals of New York LLC), METHYLTESTOSTERONE (Amneal Pharmaceuticals of New York LLC), METHYLTESTOSTERONE (Novitium Pharma LLC)
Formula
C20H30O2
Exact mass
302.2246
Mol weight
302.451
Structure
Simcomp
Class
Hormonal agent
 DG01590  Androgen receptor agonist
 DG02006  Testosterone
Remark
Same as: C07198
ATC code: G03BA02 G03EK01
Product: D00408<US>
Efficacy
Replenisher (androgen), Androgen receptor agonist
  Disease
Hypogonadotropic hypogonadism [DS:H00255]
Mammary cancer [DS:H00031]
Target
NR3C4 (AR) [HSA:367] [KO:K08557]
  Pathway
hsa04114  Oocyte meiosis
hsa05200  Pathways in cancer
Interaction
Structure map
map07226  Progesterone, androgen and estrogen receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G03 SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
   G03B ANDROGENS
    G03BA 3-oxoandrosten (4) derivatives
     G03BA02 Methyltestosterone
      D00408  Methyltestosterone (JP18/USP/INN) <US>
   G03E ANDROGENS AND FEMALE SEX HORMONES IN COMBINATION
    G03EK Androgens and female sex hormones in combination with other drugs
     G03EK01 Methyltestosterone
      D00408  Methyltestosterone (JP18/USP/INN) <US>
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Sex Hormones/Modifiers)
  Androgens
   Methyltestosterone
    D00408  Methyltestosterone (JP18/USP/INN)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for  urogenital organs and anus
  31 Other drugs for  urogenital organs and anus
   D00408  Methyltestosterone (JP18/USP/INN)
 Nourishing tonics and health supplements
  48 Other nourishing tonics and health supplements
   D00408  Methyltestosterone (JP18/USP/INN)
 Agents for integumentary system
  60 Hair remedies (incl. hair growth, hair tonic, anti-dandruff, and antipruritic)
   D00408  Methyltestosterone (JP18/USP/INN)
  61 Other agents for integumentary system
   D00408  Methyltestosterone (JP18/USP/INN)
Risk category of Japanese OTC drugs [BR:br08312]
 First-class OTC drugs
  Inorganic and organic chemicals
   Methyltestosterone
    D00408  Methyltestosterone (JP18/USP/INN)
Drug groups [BR:br08330]
 Hormonal agent
  DG01590  Androgen receptor agonist
   D00408  Methyltestosterone
  DG02006  Testosterone
   D00408  Methyltestosterone
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C4 (AR)
     D00408  Methyltestosterone (JP18/USP/INN) <US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00408  Methyltestosterone
  D00408  Methyltestosterone tablets
Other DBs
CAS: 58-18-4
PubChem: 7847474
ChEBI: 27436
LigandBox: D00408
NIKKAJI: J1.385D
KCF data

ATOM        22
            1   C1x C    20.2653  -19.1854
            2   C5x C    20.2653  -20.5401
            3   C2x C    21.4385  -21.2175
            4   C2y C    22.6118  -20.5401
            5   C1z C    22.6118  -19.1854
            6   C1x C    21.4385  -18.5080
            7   C1x C    23.7850  -21.2175
            8   C1x C    24.9582  -20.5401
            9   C1y C    24.9582  -19.1854
            10  C1y C    23.7850  -18.5080
            11  C1y C    26.1315  -18.5080
            12  C1z C    26.1315  -17.1533
            13  C1x C    24.9582  -16.4759
            14  C1x C    23.7850  -17.1533
            15  C1x C    28.4779  -18.5080
            16  C1x C    28.4779  -17.1533
            17  C1z C    27.3047  -16.4759
            18  O5x O    19.0921  -21.2175
            19  C1a C    22.6118  -17.8306
            20  C1a C    26.1315  -15.7985
            21  O1a O    27.3047  -14.7147
            22  C1a C    28.4779  -15.7985
BOND        25
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21    2  18 2
            22    5  19 1 #Up
            23   12  20 1 #Up
            24   17  21 1 #Up
            25   17  22 1 #Down