Entry

D00418                      Drug

Name

Minoxidil (JAN/USP/INN);
Loniten (TN);
Riup (TN);
Rogaine (TN)

Product

Generic

MINOXIDIL (Actavis Pharma), MINOXIDIL (American Health Packaging), MINOXIDIL (Aphena Pharma Solutions - Tennessee), MINOXIDIL (AvKARE), MINOXIDIL (Bryant Ranch Prepack), MINOXIDIL (Bryant Ranch Prepack), MINOXIDIL (Bryant Ranch Prepack), MINOXIDIL (Bryant Ranch Prepack), MINOXIDIL (Bryant Ranch Prepack), MINOXIDIL (Bryant Ranch Prepack), MINOXIDIL (Par Pharmaceutical), MINOXIDIL (REMEDYREPACK), MINOXIDIL (Sun Pharmaceutical Industries)

Formula

C9H15N5O

Exact mass

209.1277

Mol weight

209.2483

Structure

Class

Cardiovascular agent
DG01583 ATP-sensitive potassium channel opener

Remark

ATC code:

C02DC01 D11AX01

Product:

D00418<US>

Efficacy

Antihypertensive, Hair growth stimulant (topical), ATP-sensitive potassium channel opener

Disease

Hypertension [DS:H01633]

Comment

Pyrimidine derivative

Target

ABCC8(SUR1)/KCNJ11(KIR6.2) [HSA:6833 3767] [KO:K05032 K05004]

Pathway

hsa02010

ABC transporters

Interaction

Structure map

map07232

Potassium channel blocking and opening drugs

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
  C02 ANTIHYPERTENSIVES
   C02D ARTERIOLAR SMOOTH MUSCLE, AGENTS ACTING ON
    C02DC Pyrimidine derivatives
     C02DC01 Minoxidil
      D00418  Minoxidil (JAN/USP/INN) <US>
D DERMATOLOGICALS
  D11 OTHER DERMATOLOGICAL PREPARATIONS
   D11A OTHER DERMATOLOGICAL PREPARATIONS
    D11AX Other dermatologicals
     D11AX01 Minoxidil
      D00418  Minoxidil (JAN/USP/INN) <US>
USP drug classification [BR:br08302]
Cardiovascular Agents
  Vasodilators
   Direct-acting Arterial
    Minoxidil
     D00418  Minoxidil (JAN/USP/INN)
Classification of Japanese OTC drugs [BR:br08313]
Agents for integumentary system
  60 Hair remedies (incl. hair growth, hair tonic, anti-dandruff, and antipruritic)
   D00418  Minoxidil (JAN/USP/INN)
Risk category of Japanese OTC drugs [BR:br08312]
First-class OTC drugs
  Inorganic and organic chemicals
   Minoxidil
    D00418  Minoxidil (JAN/USP/INN)
Drug groups [BR:br08330]
Cardiovascular agent
  DG01583  ATP-sensitive potassium channel opener
   D00418  Minoxidil
Target-based classification of drugs [BR:br08310]
Transporters
  ABC transporters
   ABCC subfamily
    ABCC8(SUR1)/KCNJ11(KIR6.2)
     D00418  Minoxidil (JAN/USP/INN) <US>
Rx-to-OTC switch list in the USA [br08315.html]
D00418
Rx-to-OTC switch list in Japan [br08314.html]
D00418

Other DBs

CAS:	38304-91-5

PubChem:

7847484

ChEBI:

6942

PDB-CCD:

MXD[PDBj]

LigandBox:

D00418

NIKKAJI:

J19.522G

KCF data

ATOM        15
            1   C8y C    25.4688  -16.6714
            2   N1y N    26.6393  -15.9984
            3   C8x C    25.4688  -18.0236
            4   N5x N    24.3041  -15.9984
            5   C1x C    27.8100  -16.6774
            6   C1x C    26.6393  -14.6522
            7   C8y C    24.3041  -18.7025
            8   C8y C    23.1275  -16.6714
            9   C1x C    28.9805  -16.0042
            10  C1x C    27.8100  -13.9733
            11  N5y N    23.1275  -18.0236 #+
            12  N1a N    24.3041  -20.0604
            13  N1a N    21.9570  -15.9984
            14  C1x C    28.9805  -14.6522
            15  O3a O    21.1726  -18.8488 #-
BOND        16
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     2   6 1
            6     3   7 2
            7     4   8 1
            8     5   9 1
            9     6  10 1
            10    7  11 1
            11    7  12 1
            12    8  13 1
            13    9  14 1
            14   11  15 1
            15    8  11 2
            16   10  14 1